Phase 1 Clinical Study of MWN105 Injection in Healthy Chinese Volunteers

Inclusion Criteria: 1. The selected subjects should be healthy male or female individuals aged 18 to 45 years (inclusive). 2. Female subjects should have a body weight of at least 50.0 kg, and male subjects should have a body weight of at least 55.0 kg. Their body mass index (BMI) should be within the range of 19.0-28.0 kg/m² (inclusive). 3. Physical examination, vital signs, 12-lead electrocardiogram (ECG), abdominal ultrasound, and clinical laboratory test results (including serum calcitonin, coagulation function, and thyroid function) should show no clinically significant abnormalities. 4. Subjects are required to abstain from sexual activity or use two effective contraceptive methods simultaneously starting from 1 month before screening through 6 months after the last administration, and must have no plans for sperm or egg donation. Exclusion Criteria: 1. Any history of clinical severe diseases or current presence of any clinically significant diseases. 2. Those with a known history or family history of medullary thyroid carcinoma, type 2 multiple endocrine neoplasia syndrome (MEN2), or those with a history of hypothyroidism or abnormal thyroid hormone levels. 3. Subjects with a history of acute or chronic pancreatitis, symptomatic gallbladder disease, history of pancreatic injury, or other high-risk factors that may cause pancreatitis, or those with an amylase level \> 1.5 times the upper limit of the normal range (ULN) during screening. 4. Those with clinically significant gastric emptying abnormalities (such as gastric outlet obstruction), severe chronic gastrointestinal diseases (such as having had active ulcers within 6 months), long-term use of drugs that directly affect gastrointestinal motility (including but not limited to mosapride, cispamide), or those who have undergone gastrointestinal surgery within 12 weeks before screening and are assessed by the investigator as not suitable to participate in this clinical study. 5. Used any prescription drugs, herbal medicines, over-the-counter drugs, or dietary supplements within 2 weeks before administration. 6. Had an infectious disease within 4 weeks before screening, severe trauma, or a history of major surgery. 7. Received vaccines or planned to receive vaccines during the trial screening. 8. Donated blood, experienced significant blood loss (\> 450 mL), or received a blood transfusion within 12 weeks before screening.