This randomized clinical trial aims to evaluate and compare the clinical and biochemical effects of an antioxidant agent and chlorhexidine when used as adjuncts to non-surgical periodontal therapy in patients with Stage II Grade B periodontitis. Eligible participants will receive scaling and root planing (SRP) and will be randomly assigned to either the antioxidant or chlorhexidine treatment group. Clinical periodontal parameters, including plaque index, gingival index, probing depth, and clinical attachment level, will be assessed at baseline and follow-up visits. Biochemical analysis of inflammatory markers, including tumor necrosis factor-alpha (TNF-α) and interleukin-1 (IL-1), will be performed to evaluate the inflammatory response to treatment. The study aims to determine whether antioxidant therapy provides comparable or superior benefits to chlorhexidine as an adjunct to non-surgical periodontal treatment.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
36
Local application of Perioscience antioxidant gel into periodontal pockets following scaling and root planing (SRP).
Local application of High Cure chlorhexidine gel into periodontal pockets following scaling and root planing (SRP).
Local application of both High Cure chlorhexidine gel and Perioscience gel into periodontal pockets following scaling and root planing (SRP).
Conventional full-mouth scaling and root planing performed using ultrasonic and hand instruments.
Alazhar University
Cairo, Cairo Governorate, Egypt
Gingival Crevicular Fluid (GCF) Level of Interleukin-1 (IL-1)
Changes in the concentration of Interleukin-1 (IL-1) in gingival crevicular fluid (GCF) will be assessed before and after the intervention using an enzyme-linked immunosorbent assay (ELISA) with unit of measurement pg/mL .
Time frame: Baseline to 6 months after treatment
Gingival Crevicular Fluid (GCF) Level of Tumor Necrosis Factor-alpha (TNF-α)
Changes in the concentration of Tumor Necrosis Factor-alpha (TNF-α) in gingival crevicular fluid (GCF) will be assessed before and after the intervention using an enzyme-linked immunosorbent assay (ELISA) with unit of measurement pg/mL .
Time frame: Baseline and 6 months after treatment
Probing Depth (PD)
Probing depth will be measured in millimeters using a periodontal probe at the selected periodontal sites.
Time frame: Baseline to 6 months after treatment.
Gingival Index (GI)
Gingival status will be assessed using the Gingival Index, scored (0 - 3) at the selected periodontal sites.
Time frame: baseline to 6 months after treatment
Clinical Attachment Level (CAL)
Clinical attachment level will be measured in millimeters using a periodontal probe at the selected periodontal sites.
Time frame: baseline to 6 month after treatment
Plaque Index (PI)
Dental plaque accumulation will be assessed using the Plaque Index, scored (0 - 3) at the selected periodontal sites.
Time frame: baseline to 6 month after treatment
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