To study the effect of relocation from high altitude (Quito Ecuador: 2850m) to sea level on pulmonary resistance (sPAP/CO) and other hemodynamic outcomes in healthy individuals, who live permanently \>2600m.
The aim of this research is to investigate the pulmonary resistance (sPAP/CO) by echocardiography and other hemodynamic outcomes before and after relocation (high altitude near their living altitude vs. sea level) in healthy individuals, who permanently live at high altitude over 2600m.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
SUPPORTIVE_CARE
Masking
NONE
Enrollment
14
Descent from 2850m to sea level with a stay for 7 days
University Hospital of Zurich
Zurich, Switzerland
Pulmonary resistance (sPAP/CO) after 7 days at sea level
Difference/change in sPAP/CO by echocardiography between 2850m and Day 5-7 at sea level in healthy individuals
Time frame: From high altitude (2850m) to day 5-7 at sea level
Tricuspid regurgitation velocity TRV after 7 days at sea level
Difference/change in tricuspid regurgitation velocity TRV between 2850m and Day 5-7 at sea level in healthy individuals
Time frame: From high altitude (2850m) to day 5-7 at sea level
Cardiac output CO after 7 days at sea level
Difference/change in cardiac output CO between 2850m and Day 5-7 at sea level in healthy individuals
Time frame: From high altitude (2850) to day 5-7 at sea level
Tricuspid annular plan systolic excursion TAPSE after 7 days at sea level
Difference/change in tricuspid annular plan systolic excursion TAPSE between 2850m and Day 5-7 at sea level in healthy individuals
Time frame: From high altitude (2850m) to day 5-7 at sea level
Right ventricular strain after 7 days at sea level
Difference/change in right ventricular strain between 2850m and day 5-7 at sea level in healthy individuals
Time frame: From high altitude (2850m) to Day 5-7 at sea level
Right atrial pressure RAP after 7 days at sea level
Difference/change in right atrial pressure RAP between 2850m and day 5-7 at sea level in healthy individuals
Time frame: From high altitude (2850m) to Day 5-7 at sea level
Fractional area change FAC after 7 days at sea level
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Difference/change in fractional area change FAC between 2850m and day 5-7 at sea level in healthy individuals
Time frame: From high altitude (2850m) to Day 5-7 at sea level
PaO2 after 7 days at sea level
Difference/change in PaO2 (arterial blood gas analysis) between 2850m and sea level in healthy individuals
Time frame: From high altitude (2850) to day 7 at sea level
PaCO2 after 7 days at sea level
Difference/change in PaCO2 (arterial blood gas analysis) between 2850m and sea level in healthy individuals
Time frame: From high altitude (2850) to day 7 at sea level
Hemoglobin after 7 days at sea level
Difference/change in hemoglobin (arterial blood gas analysis) between 2850m and sea level in healthy individuals
Time frame: From high altitude (2850) to day 7 at sea level
pH after 7 days at sea level
Difference/change in pH (arterial blood gas analysis) between 2850m and sea level in healthy individuals
Time frame: From high altitude (2850) to day 7 at sea level
Acclimatization-Effect of pulmonary resistance (sPAP/CO) at sea level
Difference/change in pulmonary resistance (sPAP/CO) within a stay at sea level of 7 days (after relocation from high altitude) in healthy individuals
Time frame: From Day 2 to Day 5-7 at sea level
Acclimatization-Effect of tricuspid regurgitation velocity TRV at sea level
Difference/change in tricuspid regurgitation velocity TRV within a stay at sea level of 7 days (after relocation from high altitude) in healthy individuals
Time frame: From Day 2 to Day 5-7 at sea level
Acclimatization-Effect of cardiac output CO at sea level
Difference/change in cardiac output CO within a stay at sea level of 7 days (after relocation from high altitude) in healthy individuals
Time frame: From Day 2 to Day 5-7 at sea level
Acclimatization-Effect of tricuspid annular plan systolic excursion TAPSE at sea level
Difference/change in tricuspid annular plan systolic excursion TAPSE within a stay at sea level for 7 days (after relocation from high altitude) in healthy individuals
Time frame: From Day 2 to Day 5-7 at sea level
Acclimatization-Effect of right ventricular strain at sea level
Difference/change in right ventricular strain within a stay at sea level for 7 days (after relocation from high altitude) in healthy individuals
Time frame: From Day 2 to Day 5-7 at sea level
Acclimatization-Effect of right atrial pressure RAP at sea level
Difference/change in right atrial pressure RAP within a stay at sea level for 7 days (after relocation from high altitude) in healthy individuals
Time frame: From Day 2 to Day 5-7 at sea level
Acclimatization-Effect of fractional area change FAC at sea level
Difference/change in fractional area change FAC within a stay at sea level for 7 days (after relocation from high altitude) in healthy individuals
Time frame: From Day 2 to Day 5-7 at sea level
Acclimatization-Effect of PaO2 at sea level
Difference/change in PaO2 (arterial blood gas analysis) within a stay at sea level for 7 days (after relocation from high altitude) in healthy individuals
Time frame: From Day 2 to Day 7 at sea level
Acclimatization-Effect of PaCO2 at sea level
Difference/change in PaCO2 (arterial blood gas analysis) within a stay at sea level for 7 days (after relocation from high altitude) in healthy individuals
Time frame: From Day 2 to Day 7 at sea level
Acclimatization-Effect of hemoglobin at sea level
Difference/change in hemoglobin (arterial blood gas analysis) within a stay at sea level for 7 days (after relocation from high altitude) in healthy individuals
Time frame: From Day 2 to Day 7 at sea level
Acclimatization-Effect of pH at sea level
Difference/change in pH (arterial blood gas analysis) within a stay at sea level for 7 days (after relocation from high altitude) in healthy individuals
Time frame: From Day 2 to Day 7 at sea level