Assessment of Lung Function (Lufu) at Sea Level LA vs. High Altitude HA in Healthy Individuals

N/ANot Yet RecruitingNCT07804537

Silvia Ulrich Somaini14 enrolled

Overview

To study the effect of a re-ascent to high altitude (Quito Ecuador: 2850m) after a one-week stay at sea level (after prior descent from 2850m) on lung function and pulmonary resistance/reactance in healthy individuals, who live permanently \> 2600m.

The aim of this research is to investigate the lung function and pulmonary resistance/reactance before and after re-ascent (sea level for 7 days after prior descent from 2850m vs. re-ascent to 2850m) in healthy individuals, who permanently live at high altitude over 2600m.

Study Type

INTERVENTIONAL

Allocation

Purpose

SUPPORTIVE_CARE

Masking

NONE

Enrollment

Conditions

Healthy Healthy Adult High Altitude Effects High Altitude Lung Function Tests Lung Function Changes

Interventions

Re-ascent from sea level to 2850mBEHAVIORAL

Descent from 2850m to sea level with a stay for 7 days and re-ascent/return back to their usual living altitude at 2850m

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Adults aged 18-80 years and of all genders * Permanent residence \> 2600 m * healthy: no self perceived cardiopulmonary disease limiting daily activities * written informed consent to participate in the study. Exclusion Criteria: * Age \<18 years or \>80 years * Participants who cannot follow the study investigations * Participants permanently living \< 2600m * Participants who traveled and stayed overnight at altitudes \<2000 m in the past 4 weeks. * any self-perceived cardiopulmonary disease limiting daily activities

Locations (1)

University Hospital of Zurich

Zurich, Switzerland

Outcomes

Primary Outcomes

FEV1 after re-ascent to 2850m

Difference/change in forced expiratory volume in one second FEV1 between sea level (measurement on the 4th day) and day after re-ascent to 2850m in healthy individuals

Time frame: From Day 4 at sea level to the day after re-ascent (Day 9)

Secondary Outcomes

Forced Vital Capacity FVC after re-ascent to 2850m

Difference/change in forced vital capacity FVC between sea level (measurement on the 4th day) and day after re-ascent to 2850m in healthy individuals

Time frame: From Day 4 at sea level to the day after re-ascent (Day 9)

FEV1/FVC after re-ascent to 2850m

Difference/change in FEV1/FVC between sea level (measurement on the 4th day) and day after re-ascent to 2850m in healthy individuals

Time frame: From Day 4 at sea level to the day after re-ascent (Day 9)

Respiratory Impedance (forced oscillation technique) after re-ascent to 2850m

Difference/change in respiratory impedance (forced oscillation technique) between sea level (measurement on the 4th day) and day after re-ascent to 2850m in healthy individuals

Time frame: From Day 4 at sea level to the day after re-ascent (Day 9)

Respiratory resistance (forced oscillation technique) after re-ascent to 2850m

Difference/change in respiratory resistance (forced oscillation technique) between sea level (measurement on the 4th day) and day after re-ascent to 2850m in healthy individuals

Time frame: From Day 4 at sea level to the day after re-ascent (Day 9)

Respiratory reactance (forced oscillation technique) after re-ascent to 2850m

Difference/change in respiratory reactance (forced oscillation technique) between sea level (measurement on the 4th day) and day after re-ascent to 2850m in healthy individuals

Central Contacts

Silvia Ulrich, Prof. Dr. med.

CONTACT

+41442552220 silvia.ulrich@usz.ch

Michael Furian, Prof. Dr. sc. ETH

CONTACT

+41442552220

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.

Time frame: From Day 4 at sea level to the day after re-ascent (Day 9)

FEV1 after 4 days at sea level

Difference/change in FEV1 between 2850m (prior to descent) and day 4 at sea level in healthy individuals

Time frame: From high altitude (2850m) to day 4 at sea level

Forced Vital Capacity FVC after 4 days at sea level

Difference/change in forced vital capacity FVC between 2850m (prior to descent) and day 4 at sea level in healthy individuals

Time frame: From high altitude (2850m) to day 4 at sea level

FEV1/FVC after 4 days at sea level

Difference/change in FEV1/FVC between 2850m (prior to descent) and day 4 at sea level in healthy individuals

Time frame: From high altitude (2850m) to day 4 at sea level

Respiratory Impedance (forced oscillation technique) after 4 days at sea level

Difference/change in respiratory Impedance (forced oscillation technique) between 2850m (prior to descent) and day 4 at sea level in healthy individuals

Time frame: From high altitude (2850m) to day 4 at sea level

Respiratory resistance (forced oscillation technique) after 4 days at sea level

Difference/change in respiratory resistance (forced oscillation technique) between 2850m (prior to descent) and day 4 at sea level in healthy individuals

Time frame: From high altitude (2850m) to day 4 at sea level

Respiratory reactance (forced oscillation technique) after 4 days at sea level

Difference/change in respiratory reactance (forced oscillation technique) between 2850m (prior to descent) and day 4 at sea level in healthy individuals

Time frame: From high altitude (2850m) to day 4 at sea level

FEV1 pre-descent and after re-ascent (2850m)

Difference/change in FEV1 at 2850m with a one-week stay at sea level in between (day pre-descent vs. day after re-ascent) in healthy individuals

Time frame: Baseline at 2850m followed by a one-week stay at sea level to the day after re-ascent back to 2850m (time frame approximately 11 days)

Forced Vital Capacity FVC pre-descent and after re-ascent (2850m)

Difference/change in forced vital capacity FVC at 2850m with a one-week stay at sea level in between (day pre-descent vs. day after re-ascent) in healthy individuals

Time frame: Baseline at 2850m followed by a one-week stay at sea level to the day after re-ascent back to 2850m (time frame approximately 11 days)

FEV1/FVC pre-descent and after re-ascent (2850m)

Difference/change in FEV1/FVC at 2850m with a one-week stay at sea level in between (day pre-descent vs. day after re-ascent) in healthy individuals

Time frame: Baseline at 2850m followed by a one-week stay at sea level to the day after re-ascent back to 2850m (time frame approximately 11 days)

Respiratory Impedance (forced oscillation technique) pre-descent and after re-ascent (2850m)

Difference/change in respiratory impedance (forced oscillation technique) at 2850m with a one-week stay at sea level in between (day pre-descent vs. day after re-ascent) in healthy individuals

Time frame: Baseline at 2850m followed by a one-week stay at sea level to the day after re-ascent back to 2850m (time frame approximately 11 days)

Respiratory resistance (forced oscillation technique) pre-descent and after re-ascent (2850m)

Difference/change in respiratory resistance (forced oscillation technique) at 2850m with a one-week stay at sea level in between (day pre-descent vs. day after re-ascent) in healthy individuals

Time frame: Baseline at 2850m followed by a one-week stay at sea level to the day after re-ascent back to 2850m (time frame approximately 11 days)

Respiratory reactance (forced oscillation technique) pre-descent and after re-ascent (2850m)

Difference/change in respiratory reactance (forced oscillation technique) at 2850m with a one-week stay at sea level in between (day pre-descent vs. day after re-ascent) in healthy individuals

Time frame: Baseline at 2850m followed by a one-week stay at sea level to the day after re-ascent back to 2850m (time frame approximately 11 days)