To study the effect of a re-ascent after a one-week stay at sea level (after prior descent from 2850m) to high altitude (Quito Ecuador: 2850m) on pulmonary resistance (sPAP/CO) and other hemodynamic outcomes in healthy individuals, who live permanently \>2600m.
The aim of this research is to investigate the pulmonary resistance (sPAP/CO) by echocardiography and other hemodynamic outcomes before and after re-ascent (sea level for 7 days vs. re-ascent to 2850m) in healthy individuals, who permanently live at high altitude over 2600m
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
SUPPORTIVE_CARE
Masking
NONE
Enrollment
14
After 7 days at sea level return/re-ascent to their usual living altitude at 2850m
University Hospital of Zurich
Zurich, Switzerland
Pulmonary resistance (sPAP/CO) after re-ascent to 2850m
Difference in sPAP/CO by echocardiography between sea level (after one-week stay) and day after re-ascent at 2850m in healthy individuals
Time frame: From Day 5-7 at sea level to the day after re-ascent
Tricuspid regurgitation velocity TRV after re-ascent to 2850m
Difference/change in tricuspid regurgitation velocity TRV between sea level (after one-week stay) and day after re-ascent at 2850m in healthy individuals
Time frame: From Day 5-7 at sea level to the day after re-ascent
Cardiac output CO after re-ascent to 2850m
Difference/change in cardiac output CO between sea level (after one-week stay) and Day after re-ascent to 2850m in healthy individuals
Time frame: From Day 5-7 at sea level to the day after re-ascent
Tricuspid annular plan systolic excursion TAPSE after re-ascent to 2850m
Difference/change in tricuspid annular plan systolic excursion TAPSE between sea level (after one-week stay) and Day after re-ascent to 2850m in healthy individuals
Time frame: From Day 5-7 at sea level to day after re-ascent
Right ventricular strain after re-ascent to 2850m
Difference/change in right ventricular strain between sea level (after one-week stay) and Day after re-ascent to 2850m in healthy individuals
Time frame: From Day 5-7 at sea level to day after re-ascent
Right atrial pressure RAP after re-ascent to 2850m
Difference/change in rightatrial pressure RAP between sea level (after one-week stay) and Day after re-ascent to 2850m in healthy individuals
Time frame: From Day 5-7 at sea level to day after re-ascent
Fractional area change FAC after re-ascent to 2850m
Difference/change in fractional area change FAC between sea level (after one-week stay) and Day after re-ascent to 2850m in healthy individuals
Time frame: From Day 5-7 at sea level to day after re-ascent
PaO2 after re-ascent to 2850m
Difference/change in PaO2 (arterial blood gas analysis) between sea level (after one-week stay) and day after re-ascent to 2850m in healthy individuals
Time frame: From Day 7 at sea level to day after re-ascent (time frame of 3 days)
PaCO2 after re-ascent to 2850m
Difference/change in PaCO2 (arterial blood gas analysis) between sea level (after one-week stay) and day after re-ascent to 2850m in healthy individuals
Time frame: From Day 7 at sea level to day after re-ascent (time frame of 3 days)
Hemoglobin after re-ascent to 2850m
Difference/change in hemoglobin (arterial blood gas analysis) between sea level (after one-week stay) and day after re-ascent to 2850m in healthy individuals
Time frame: From Day 7 at sea level to day after re-ascent (time frame of 3 days)
pH after re-ascent to 2850m
Difference/change in pH (arterial blood gas analysis) between sea level (after one-week stay) and day after re-ascent to 2850m in healthy individuals
Time frame: From Day 7 at sea level to day after re-ascent (time frame of 3 days)
Pulmonary resistance (sPAP/CO) pre-descent to after re-ascent
Difference/change in pulmonary resistance (sPAP/CO) at 2850m with a one-week stay at sea level in between (day pre-descent vs. day after re-ascent) in healthy individuals
Time frame: Baseline at 2850m followed by a one-week stay at sea level to the day after re-ascent back to 2850m (time frame approximately 11 days)
Tricuspid regurgitation velocity TRV pre-descent to after re-ascent
Difference/change in tricuspid regurgitation velocity TRV at 2850m with a one-week stay at sea level in between (day pre-descent vs. day after re-ascent) in healthy individuals
Time frame: Baseline at 2850m followed by a one-week stay at sea level to the day after re-ascent back to 2850m (time frame approximately 11 days)
Cardiac output CO pre-descent to after re-ascent
Difference/change in cardiac output CO at 2850m with a one-week stay at sea level in between (day pre-descent vs. day after re-ascent) in healthy individuals
Time frame: Baseline at 2850m followed by a one-week stay at sea level to the day after re-ascent back to 2850m (time frame approximately 11 days)
Tricuspid annular plan systolic excursion TAPSE pre-descent to after re-ascent
Difference/change in tricuspid annular plan systolic excursion TAPSE at 2850m with a one-week stay at sea level in between (day pre-descent vs. day after re-ascent) in healthy individuals
Time frame: Baseline at 2850m followed by a one-week stay at sea level to the day after re-ascent back to 2850m (time frame approximately 11 days)
Right ventricular strain pre-descent to after re-ascent
Difference/change in right ventricular strain at 2850m with a one-week stay at sea level in between (day pre-descent vs. day after re-ascent) in healthy individuals
Time frame: Baseline at 2850m followed by a one-week stay at sea level to the day after re-ascent back to 2850m (time frame approximately 11 days)
Right atrial pressure RAP pre-descent to after re-ascent
Difference/change in right atrial pressure at 2850m with a one-week stay at sea level in between (day pre-descent vs. day after re-ascent) in healthy individuals
Time frame: Baseline at 2850m followed by a one-week stay at sea level to the day after re-ascent back to 2850m (time frame approximately 11 days)
Fractional area change FAC pre-descent to after re-ascent
Difference/change in fractional area change FAC at 2850m with a one-week stay at sea level in between (day pre-descent vs. day after re-ascent) in healthy individuals
Time frame: Baseline at 2850m followed by a one-week stay at sea level to the day after re-ascent back to 2850m (time frame approximately 11 days)
PaO2 pre-descent to after re-ascent
Difference/change in PaO2 (arterial blood gas analysis) at 2850m with a one-week stay at sea level in between (day pre-descent vs. day after re-ascent) in healthy individuals
Time frame: Baseline at 2850m followed by a one-week stay at sea level to the day after re-ascent back to 2850m (time frame approximately 11 days)
PaCO2 pre-descent to after re-ascent
Difference/change in PaCO2 (arterial blood gas analysis) at 2850m with a one-week stay at sea level in between (day pre-descent vs. day after re-ascent) in healthy individuals
Time frame: Baseline at 2850m followed by a one-week stay at sea level to the day after re-ascent back to 2850m (time frame approximately 11 days)
Hemoglobin pre-descent to after re-ascent
Difference/change in hemoglobin (arterial blood gas analysis) at 2850m with a one-week stay at sea level in between (day pre-descent vs. day after re-ascent) in healthy individuals
Time frame: Baseline at 2850m followed by a one-week stay at sea level to the day after re-ascent back to 2850m (time frame approximately 11 days)
pH pre-descent to after re-ascent
Difference/change in pH (arterial blood gas analysis) at 2850m with a one-week stay at sea level in between (day pre-descent vs. day after re-ascent) in healthy individuals
Time frame: Baseline at 2850m followed by a one-week stay at sea level to the day after re-ascent back to 2850m (time frame approximately 11 days)
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