Fertility Decision and Outcomes in Young Women With Breast Cancer

N/AActive Not RecruitingNCT07804745

Second Affiliated Hospital, Zhejiang University, School of Medicine300 enrolled

Overview

This observational study is to learn about the fertility outcomes and decision after breast cancer diagnosis, and the current status of fertility consultation and decision support in young women diagnosed with breast cancer in China.

Study Type

OBSERVATIONAL

Enrollment

300

Conditions

Breast Cancer - Female Fertility

Interventions

No intervention (observational study)OTHER

This is an observational study. Our study is based on the real-world conditions. We don't have any intervention.

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 40 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Female breast cancer patients, aged 18-40 years at diagnosis. * Treated at the three participating hospitals between 1 January 2013 and 31 December 2023. * Complete clinical documentation available in the electronic medical record system. * Had no child before cancer diagnosis. Exclusion Criteria: * Prior reproductive compromise (surgical or diagnostic infertility or pre-existing infertility factors) before cancer diagnosis. * Presented with de novo stage IV (metastatic) disease. * Had a history of other malignancies. * Patients who refuse to participate or cannot be contacted for follow-up.

Locations (3)

Jilin Cancer Hospital

Changchun, Jilin, China

Hangzhou First People's Hospital

Hangzhou, Zhejiang, China

the Second Affiliated Hospital of Zhejiang University School of Medicine

Hangzhou, Zhejiang, China

Outcomes

Primary Outcomes

Childbearing after breast cancer diagnosis

We will follow up with patients who had not given birth before their cancer diagnosis, to establish whether they had given birth by the end of follow-up. It will be assessed by patient self-report during follow-up and available medical records. The outcome will be recorded as a binary variable (yes/no).

Time frame: Up to 2026

Secondary Outcomes

Fertility preservation measures uptake

We will calculate the proportion of patients who underwent fertility preservation procedures in cases vs. controls.

Time frame: up to 2026

Multidisciplinary collaboration involvement

We will calculate the proportion of patients with multidisciplinary team discussion or referral involving reproductive medicine, gynecology, or fertility specialists.

Time frame: up to 2026

Data from ClinicalTrials.gov

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