NLR and PLR in H. Pylori-Associated Gastritis

N/ANot Yet RecruitingNCT07805005

Assiut University90 enrolled

Overview

This cross-sectional study aims to evaluate the role of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) as inflammatory markers in patients with Helicobacter pylori-associated gastritis at Assiut University Hospitals.

Helicobacter pylori is a major cause of gastritis and is associated with chronic gastric inflammation. Systemic inflammatory markers derived from complete blood count, such as the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR), have been proposed as simple and inexpensive indicators of inflammation. This cross-sectional study will include adult patients with dyspepsia undergoing testing for H. pylori by endoscopy and biopsy at Assiut University Hospitals. Complete blood count will be performed to calculate NLR and PLR. The study will assess the association of these ratios with the presence of H. pylori infection and the severity of gastritis.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Helicobacter Pylori Infection Gastritis Dyspepsia

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * \- Age 18 years or older * Patients with dyspepsia * Patients undergoing endoscopy and biopsy for H. pylori testing * Willingness to provide informed consent Exclusion Criteria: * \- Hematological diseases * Active infection other than H. pylori * Chronic inflammatory or autoimmune diseases * Malignancy * Recent use of steroids or immunosuppressive drugs * Recent acute bleeding

Outcomes

Primary Outcomes

Neutrophil-to-lymphocyte ratio (NLR) in H. pylori-associated gastritis

Neutrophil-to-lymphocyte ratio calculated from complete blood count in patients with confirmed H. pylori-associated gastritis compared with patients without H. pylori infection.

Time frame: Baseline

Secondary Outcomes

Platelet-to-lymphocyte ratio (PLR)

Platelet-to-lymphocyte ratio calculated from complete blood count in patients with and without H. pylori infection.

Time frame: Baseline

Diagnostic performance of NLR

Sensitivity, specificity, and optimal cutoff value of NLR for predicting H. pylori infection using receiver operating characteristic (ROC) curve analysis.

Time frame: Baseline

Diagnostic performance of PLR

Sensitivity, specificity, and optimal cutoff value of PLR for predicting H. pylori infection using ROC curve analysis.

Time frame: Baseline

Correlation of NLR and PLR with severity of gastritis

Correlation coefficient between neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) values and the severity grade of gastritis based on endoscopic and/or histopathological findings, using Spearman or Pearson correlation as appropriate.

Time frame: Baseline

Central Contacts

Hadeer A Mohamed, Resident

CONTACT

+20 11 25445957 Hadeer.18313571@med.aun.edu.eg

Data from ClinicalTrials.gov

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