Multi-Center Study of Natural History in Atypical Parkinsonian Syndromes (MAPS-NH)

Second Affiliated Hospital of Soochow University500 enrolled

Overview

This goal of this observational study is to clarify the variations in the natural course of atypical parkinsonian syndromes (APS, including MSA, DLB, PSP, and CBD), such as the progression rate of motor and non-motor symptoms and characteristic imaging evolution patterns. Establish a comprehensive assessment framework for APS, and develop clinical and biological databases to identify biomarkers with early predictive value.

Study Type

OBSERVATIONAL

Enrollment

500

Conditions

Multiple System Atrophy Dementia With Lewy Bodies (DLB)Progressive Supranuclear Palsy (PSP)Corticobasal Degeneration (CBD)

Interventions

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. MSA : Meets the "probable MSA" criteria in the 2022 Chinese expert consensus on MSA diagnosis (MSA-P or MSA-C subtype); disease duration ≤3 years (from onset of first motor symptoms) . 2. DLB : Meets "probable DLB" criteria per the 2017 McKeith diagnostic criteria; MMSE ≥18 (to exclude severe dementia confounding assessment) . 3. PSP : Meets "probable PSP-Richardson syndrome" criteria per the 2017 PSP diagnostic standards; vertical gaze palsy or postural instability with duration ≤2 years . 4. CBD : Meets "probable CBD" criteria per the 2019 Chinese expert consensus on corticobasal degeneration diagnosis and treatment; asymmetric cortical symptoms (apraxia/dystonia/alien limb). Exclusion Criteria: 1. Parkinson's disease , spinocerebellar ataxia (SCA) and other secondary autonomic failure . 2. Vascular parkinsonism , Parkinsonism caused by stroke , tumor , or immune-mediated encephalitis .

Locations (20)

Changshu Hospital Affiliated to Nanjing University of Chinese Medicine

Changshu, Jiangsu, China

RECRUITING

The second People's Hospital of Huai'an

Huai'an, Jiangsu, China

NOT_YET_RECRUITING

The First People's Hospial of Kunshan

Kunshan, Jiangsu, China

NOT_YET_RECRUITING

Jiangsu Province Official Hospital

Nanjing, Jiangsu, China

NOT_YET_RECRUITING

The Second Affiliated Hospital of Nantong University

Nantong, Jiangsu, China

NOT_YET_RECRUITING

Jiangsu Province (Suqian) Hospital

Suqian, Jiangsu, China

RECRUITING

The Forth Affiliated Hospital of Soochow University

Suzhou, Jiangsu, China

RECRUITING

The Second Affiliated Hospital of Soochow University

Suzhou, Jiangsu, China

RECRUITING

The Second Affiliated Hospital of Xuzhou Medical University

Xuzhou, Jiangsu, China

NOT_YET_RECRUITING

Yancheng Third People's Hospital

Yancheng, Jiangsu, China

RECRUITING

...and 10 more locations

Outcomes

Primary Outcomes

Natural disease progression of various atypical parkinsonian syndromes

To observe the differences in the natural disease progression of various atypical parkinsonian syndromes (APS, including MSA, DLB, PSP, and CBD), such as the progression rates of motor and non-motor symptoms and the patterns of imaging evolution. The preliminary study design involves a follow-up period of 3 years, with assessments of clinical phenotypes and/or biomarker changes every 6 months.

Time frame: up to 36 months

Multi-Center Study of Natural History in Atypical Parkinsonian Syndromes (MAPS-NH)

Overview

Conditions

Interventions

Eligibility

Locations (20)

Outcomes

Primary Outcomes

Central Contacts