Comparison Between Opioid-Free Anaesthesia Versus Opioid Based Anesthesia in Reduction Postoperative Nausea and Vomiting (PONV)After Thoracoscopic Lung Resection.

N/ANot Yet RecruitingNCT07806162

Sohag University120 enrolled

Overview

The invistigators hypothesized that a protocolized OFA technique would lower the occurance of PONV in patients undergoing thoracoscopic lung surgery compared to standard opioid-based anaesthesia.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

TRIPLE

Enrollment

120

Conditions

PONV

Interventions

Opioid Free AnaesthesiaDRUG

The OFA group protocol consists of a combination of intravenous lidocaine, ketamine, dexmedetomidine, and propofol TIVA.

conventential opioid-based anaesthesia (OBA,DRUG

The OBA group protocol consists of balanced anaesthesia with fentanyl plus sevoflurane.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria:- * Eligible participants were adults (18-80 years). * Prepared for elective thoracoscopic lobectomy or segmentectomy for lung cancer under general anaesthesia Exclusion Criteria: * Contraindication to any study drug (e.g., heart block, severe liver disease, allergy). * Chronic opioid use (\>30 MME/day for \>3 months). * Patients with renal impairment (e GFR \<30 mL/min). * Pregnancy. * Inability to comprehend pain scales.

Outcomes

Primary Outcomes

the occurrence of PONV during the initial 24 hours

Time frame: 24 hours

Secondary Outcomes

total opioid consumption over 24 hour (expressed as morphine milligram equivalents.

Time frame: 24 hours

pain intensity scores (numerical rating scale NRS 0-10)

Time frame: 24 hours

recovery quality (QoR-15 score)

Time frame: 24 hours

Data from ClinicalTrials.gov

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