This cross-sectional study aims to determine the frequency, pattern, and predictors of liver function test abnormalities among children and adolescents with type 1 diabetes mellitus attending Assiut University Children Hospital.
Type 1 diabetes mellitus is associated with hepatic involvement, including glycogenic hepatopathy and metabolic dysfunction-associated steatotic liver disease. Liver function test abnormalities are reported in a significant proportion of pediatric patients with type 1 diabetes, yet data from Egypt remain limited. This cross-sectional study will include children and adolescents aged 1 to 18 years with confirmed type 1 diabetes mellitus on insulin therapy. Clinical data, anthropometric measurements, and laboratory investigations including liver function tests will be collected. The study will determine the frequency and patterns of LFT abnormalities and identify independent clinical and biochemical predictors.
Study Type
OBSERVATIONAL
Enrollment
101
Frequency of liver function test abnormalities
Proportion of children and adolescents with type 1 diabetes mellitus who have abnormal liver function tests (elevated ALT, AST, GGT, ALP, or bilirubin, or decreased albumin), expressed as percentage.
Time frame: Baseline
Pattern of LFT abnormalities
Characterization of LFT abnormality patterns (hepatocellular, cholestatic, mixed, or synthetic dysfunction)
Time frame: Baseline
Independent predictors of LFT abnormalities
Clinical and biochemical factors independently associated with abnormal liver function tests using multivariable logistic regression analysis.
Time frame: Baseline
Association with glycemic control
Comparison of LFT abnormalities between patients with good and poor glycemic control based on HbA1c levels.
Time frame: Baseline
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