Hair Regrowth Following Partial Thickness Removal of SSCIS

N/ANot Yet RecruitingNCT07809191

The Cooper Health System15 enrolled

Overview

Participants are being approached to participate in this study because they are undergoing surgery for a skin cancer known as squamous cell carcinoma in situ (SCCIS) on the scalp. Standard surgical techniques may remove deeper structures that contain hair follicles, which can result in permanent hair loss. This study evaluates whether a modified surgical technique, known as partial thickness excision, can preserve hair growth and improve cosmetic outcomes. Participation involves minimal risk beyond the standard risks of Mohs surgery. If patients choose to participate, their surgery will be performed using this technique, and photographs will be taken over time to evaluate hair regrowth and healing.

Study Type

INTERVENTIONAL

Allocation

Purpose

PREVENTION

Masking

NONE

Enrollment

Conditions

Squamous Cell Carcinoma (Skin)Squamous Cell Carcinoma in Situ Alopecia

Interventions

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Adults ≥ 18 years old * Histologically confirmed SCCIS * Lesions located in the hair-bearing scalp * Ability to provide informed consent Exclusion Criteria: * Invasive, poorly differentiated, or high-risk SCC features (e.g., perineural invasion) * Recurrent SCC at the same site * Prior radiation therapy to the scalp * Scarring alopecia or active inflammatory scalp disease at the treatment site * Immunosuppression that, in the investigator's judgement, increases oncologic risk * Use of topical minoxidil, oral minoxidil, finasteride, spironolactone, or other hair-growth promoting agents

Outcomes

Primary Outcomes

Hair Growth measured clinically by hair density percentage compared to baseline photo

To evaluate hair growth following partial thickness excision of SCCIS at 3 and 6 months post-procedure.

Time frame: 3 and 6 months post-procedure.

Secondary Outcomes

Clearance of SCCIS measured by Mohs surgeons' interpretation of margins on surgical slides.

To assess clinical and histologic clearance of SCCIS treated with partial-thickness excision.

Time frame: Immediately following the final Mohs stage during the index procedure

Patient Satisfaction measured via patient satisfaction questionnaire

To evaluate patient-reported satisfaction with hair density and cosmetic outcome. "Are you satisfied with amount of hair//appearance of skin/result of treatment?" etc. on scale of 1-10. 1 being not satisfied and 10 being very satisfied/.

Time frame: 3 and 6 months post-procedure

Complications

To document wound-healing, complications, and the need for additional treatment.

Time frame: 2 weeks post-procedure, 3 months post-procedure, and 6 months post-procedure