Adding a perioperative lidocaine infusion (1.5 mg/kg loading + 1.5 mg/kg/h) to bilateral EOIB and low dose fentanyl loading reduces intraoperative fentanyl consumption (ANI guided rescue) compared to placebo, without increasing adverse events.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
100
Adding a perioperative lidocaine infusion (1.5 mg/kg loading + 1.5 mg/kg/h) to bilateral EOIB and low dose fentanyl loading reduces intraoperative fentanyl consumption (ANI guided rescue) compared to placebo, without increasing adverse events.
Bilateral EOIB + fentanyl 1 μg/kg loading + normal saline loading (equivalent volume) + normal saline infusion (equivalent rate).
Faculty of Medicine
Alexandria, Egypt
RECRUITINGTotal intraoperative fentanyl consumption
Total intraoperative fentanyl consumption (μg) = loading dose (1 μg/kg) + rescue boluses.
Time frame: Intraoperative time, during surgery
Postoperative morphine consumption
Postoperative morphine consumption (mg) at 24 hours.
Time frame: The first 24 hours
First rescue fentanyl and time to first postoperative morphine
Time to first rescue fentanyl (from induction to first bolus) and Time to first postoperative morphine (from PACU arrival to first dose).
Time frame: The first 24 hours
Pain scores
Pain scores (VAS score ranging 0-100) at Post Anesthetic Care Unit arrival, 1 hour, 2 hours, 6 hours, 12 hours, 24 hours.
Time frame: Upon arrival, 1 hour, 2 hours, 6 hours, 12 hours, 24 hours.
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