Brain Network Characteristics of Pain Patients Based on Magnetoencephalography

Qilu Hospital of Shandong University1,200 enrolled

Overview

This is a single-center prospective cohort study. We plan to enroll at least 1,000 patients with muscle pain (VAS ≥ 3) and 200 healthy controls. The study aims to investigate neural oscillatory and functional connectivity characteristics in muscle pain patients using magnetoencephalography (MEG), and to analyze their associations with clinical phenotypes including pain intensity, emotional status, sleep quality, disease duration, and sex. Furthermore, we aim to develop a prognostic model for pain outcome. All pain patients will undergo baseline assessments including MEG (with working-memory task, resting-state, and stimulus-evoked paradigms), brain MRI, and a series of clinical scales (VAS, MPQ, HAMA, HAMD, PSQI, ODI, NDI, SPADI, IKDC, WOMAC, DASH, etc.). They will then be followed up at 1, 3, and 6 months, with repeated collection of pain and functional outcome measures. Multivariate regression, mixed-effects models, and penalized regression will be employed to build prediction models. Model performance will be evaluated using AUC, calibration curves, and bootstrap internal validation. We aim to identify candidate objective neural biomarkers to provide a scientific basis for objective pain assessment and stratified management.

Study Type

OBSERVATIONAL

Enrollment

1,200

Conditions

Muscle Pain

Interventions

Magnetoencephalography

MEG is a technique that passively detects weak magnetic field signals generated by intracellular currents in the brain, using superconducting or atomic magnetometers within a magnetically shielded room. By co-registering the MEG signals with MRI for source localization, and performing power spectral analysis across different frequency bands, it enables non-invasive, high temporal-resolution assessment of brain function.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 70 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: 1. Meet the diagnostic criteria for muscle pain as specified in the Clinical Diagnosis Guidelines: Volume of Physical Medicine and Rehabilitation 2. VAS score ≥ 3 points. 3. Aged 18-70 years. 4. Lesions located in the soft tissues of the neck, shoulder, or lumbodorsal region, accompanied by tender points. 5. Able to understand and cooperate in completing the scales and undergoing MEG and MRI examinations. 6. Has signed the informed consent form Exclusion Criteria: 1. History of previous related disorders in the neck, shoulder, or lumbodorsal region. 2. Recent use of medications that significantly affect central excitability and inability to stabilize the condition. 3. Contraindications to MEG or MRI. 4. Presence of ferromagnetic metals implanted in the body (e.g., metal dentures, aneurysm clips, pacemakers, stents, steel plates, etc.), claustrophobia that prevents MEG examination, or failed data acquisition. 5. Concurrent severe diseases of the heart, brain, kidney, or other major organs. 6. History of muscle diseases such as tuberculosis, rheumatism, or infection. 7. Obvious cognitive impairment or communication difficulties that prevent cooperation with this study.

Locations (1)

Qilu hospital, Jinan, Shangdong

Jinan, Shandong, China

RECRUITING

Outcomes

Primary Outcomes

Visual Analogue Scale

Uses a 0-10 cm linear scale, with 0 representing no pain and 10 representing the worst imaginable pain; participants mark their current pain level based on subjective feeling