This study aimed to evaluate the effectiveness of saccharomyces-based treatment in children with acute diarrhea aged 6 months to 5 years compared to children treated with standard methods.
A total of 206 children diagnosed with acute diarrhea will be evaluated and divided into two groups based on a random distribution list: Group A and Group B. Group A will be treated with standard methods including fluid replacement and zinc according to the Ministry of Health's protocol. Group B will be treated similarly to Group A, but with the addition of Saccharomyces boulardii at a dose of 250 to 750 mg per day until discharge. Both groups of children will receive the same counseling and monitoring, with guidance provided to parents. Caregivers are advised to record symptoms and stool diaries daily.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
206
Children will receive standard treatment including fluid and zinc supplementation. In addition, they will receive Saccharomyces boulardii supplementation from admission to discharge.
Children will be treated with standard methods involving fluid and zinc supplementation, without the use of any probiotics.
Can Tho University of Medicine and Pharmacy
Can Tho, Vietnam
Duration of diarrhea
The cessation of acute diarrhea is determined when children met following criteria: 1. Passing soft or formed stools twice in a row. 2. No bowel movements recorded for 12 consecutive hours. 3. Stool consistency returns to normal, corresponding to categories 3 to 5 on the Bristol stool scale.
Time frame: Immediately after the intervention
The frequency of stool
Total number of bowel movements per day
Time frame: At day 1, 3, 5
Stool consistency assessed by Bristol stool chart
The Bristol stool chart has 7 pictures of stool appearance. The number 1 mean hard stool and number 7 mean watery stool.
Time frame: At day 1, 3, 5
Length of hospitalization
The total length of hospitalization, measured in days
Time frame: Immediately after the intervention
Adverse events
The occurrence of adverse events during treatment, including such as rash and bloating.
Time frame: Immediately after the intervention
Cost effectiveness
Total Cost per child from date of admission until discharge
Time frame: Immediately after the intervention
Rate of Hospital readmission
The proportion of participants who were readmitted to the hospital after discharge
Time frame: At day 14 and 28 after discharge from the hospital.
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