The study aims to investigate whether proton therapy is feasible in a national setting and whether proton therapy can reduce the risk of late toxicity (secondary cancers and heart toxicity) compared to foton therapy.
Patients are referred for proton therapy based on a reduction of risk of late toxicity which is established on consensus guidelines and multidisciplinary discussions in a study panel/consensus conference. However, this reduction is calculated based on the referring center's treatment planning scan and patient setup. The aim of this national study is to investigate whether the calculated reduction of risk of toxicity with proton therapy at the referring centers differs from the actual delivered plan at DCPT (ΔNTCP in delivered proton therapy plan versus reference photon plan from referring center). The study also aims to investigate effect and side effects of proton and photon radiotherapy, including a systematically prospective registration of acute and late side effects and to evaluate the use of a model-based approach to select patients for proton therapy.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
139
If selected, patients will recieve protontherapy instead of photon therapy
Dept. of oncology
Copenhagen, Select A State, Denmark
RECRUITINGCorrelation between ΔNTCP_expected and ΔNTCP_delivered.
The correlation between ΔNTCP\_expected and ΔNTCP\_delivered, is an investigation to see whether the ΔNTCP (ΔNTCP\_expected) calculated from the planning CT from the refering center, correlates with the ΔNTCP from the actual delivered plan (ΔNTCP\_delivered) at the Danish Centre for Particle Therapy.
Time frame: From enrollment to end of radiotherapy, average 5 weeks.
Incidence of acute, late toxicity and other events
A) Acute toxicity 1. Radiation dermatitis 2. Cough 3. Fatigue 4. Dysphagia Add a 2nd Outcome Measure B) Incidence of: 1. secondary cancers (breast and lung) 2. other secondary cancers within the radiation field. 3. Myocardial infarction 4. Other cardiac events Add a 3rd Outcome Measure C) Overall survival Add a 4th Outcome Measure D) Recurrence free survival
Time frame: From enrollment to 20 years after end of radiation
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