Hyperpolarized Xenon MRI in Adults With Pulmonary Hypertension in Interstitial Lung Disease and Systemic Sclerosis

Inclusion Criteria: * Age ≥18 years at enrollment. * Participant is willing and able to provide written informed consent. * Able (in the Investigator's opinion) and willing to comply with all study requirements. * Participant has or is suspected to have one of the following pulmonary conditions: * Healthy volunteers: aged 18-30 years; no known cardiopulmonary disease; has not smoked tobacco products in the previous 5 years; smoking history, if any, is less than or equal to 5 pack-years; no history of using other inhaled products more than 1 time per week for \> 1 year OR * ILD-PH: ≥18 years; ILD diagnosis; precapillary PH by RHC (mPAP \>20 mmHg, PVR \>2 WU, PCWP ≤15 mmHg) within the specified window OR * SSc: systemic sclerosis diagnosis with or without PH Exclusion Criteria: * Any condition which, in the opinion of the Investigator, would make it unsafe or unsuitable for the participants to undergo MRI (for example: presence of an implanted or external MRI unsafe device that cannot be removed, body weight exceeding table limitations, inability to lie flat, or severe claustrophobia). * Inability to hold breath for 10-15 seconds for required imaging or for completion of DLCO measurements. * Active pulmonary infection or lung cancer. * Recent respiratory infection or pulmonary disease exacerbation within 4 weeks of screening. * Participants who are known to be pregnant or lactating. * Concurrent enrollment and participation in a study which, in the opinion of the Investigator, would interfere with the study compliance, or outcome assessments or would prohibit the collection of the required data points.