The study aim is to determine whether acute inhibition of endogenous prostaglandin synthesis by paracetamol affects the release of gut hormones, glucose absorption and glycemia in healthy young individuals
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
TRIPLE
Enrollment
12
Paracetamol is used as a tool to block prostaglandin synthesis
A placebo will be administered to be able to determine the effect of paracetamol on prostaglandin synthesis
Department of Biomedical Sciences, The Panum Institute, University of Copenhagen,
Copenhagen, Capital, Denmark
RECRUITINGHvidovre Hospital, Copenhagen University Hospital
Hvidovre, Denmark
RECRUITINGGlucagon-like peptide 1
Plasma concentration
Time frame: From baseline samples (-15, 0 min) until the end of the meal test at t = 180min
Glucose
Plasma concentration
Time frame: From baseline samples (-15, 0 min) until the end of the meal test at t = 180min
Gastrin
Plasma concentration
Time frame: From baseline samples (-15, 0 min) until the end of the meal test at t = 180min
Cholecystokinin
Plasma concentration
Time frame: From baseline samples (-15, 0 min) until the end of the meal test at t = 180min
Glucose-dependent insulinotropic polypeptide (GIP)
Plasma concentration
Time frame: From baseline samples (-15, 0 min) until the end of the meal test at t = 180min
C-peptide
Plasma concentration
Time frame: From baseline samples (-15, 0 min) until the end of the meal test at t = 180min
Glucagon
Plasma concentration
Time frame: From baseline samples (-15, 0 min) until the end of the meal test at t = 180min
Pancreatic polypeptide
Plasma concentration
Time frame: From baseline samples (-15, 0 min) until the end of the meal test at t = 180min
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3-OMG
Plasma concentration
Time frame: From baseline samples (-15, 0 min) until the end of the meal test at t = 180min