This prospective cohort study aims to identify the independent predictors of prolonged mechanical ventilation in preterm infants admitted to the Neonatal Intensive Care Unit of Assiut University Children Hospital.
Prolonged mechanical ventilation in preterm infants is associated with increased morbidity including bronchopulmonary dysplasia and neurodevelopmental impairment. This prospective observational study will include preterm infants (born before 37 completed weeks) who require invasive mechanical ventilation. Infants will be classified into two groups according to the duration of invasive mechanical ventilation: prolonged (\>7 days or frequent reintubation) and non-prolonged (≤7 days). clinical, perinatal, and laboratory predictors of prolonged mechanical ventilation will be evaluated.
Study Type
OBSERVATIONAL
Enrollment
100
Occurrence of prolonged mechanical ventilation
Proportion of preterm infants who require invasive mechanical ventilation for more than 7 days or frequent reintubation.
Time frame: Up to 30 days
Duration of invasive mechanical ventilation
Total number of days of invasive mechanical ventilation.
Time frame: Up to 30 days
Successful extubation rate
Proportion of infants who are successfully extubated without re-intubation within 48-72 hours.
Time frame: Up to 30 days
Incidence of bronchopulmonary dysplasia
Proportion of infants diagnosed with bronchopulmonary dysplasia.
Time frame: Up to 30 days
Incidence of neonatal sepsis
Proportion of infants diagnosed with neonatal sepsis.
Time frame: Up to 30 days
Duration of NICU stay
Length of stay in the neonatal intensive care unit in days.
Time frame: Up to 30 days
In-hospital mortality
Proportion of infants who die before hospital discharge.
Time frame: Up to 30 days
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