This prospective cohort study aims to identify the clinical, laboratory, and echocardiographic predictors of outcomes among neonates diagnosed with persistent pulmonary hypertension of the newborn at Assiut University Children Hospital.
Persistent pulmonary hypertension of the newborn (PPHN) is a serious condition characterized by failure of the normal postnatal decline in pulmonary vascular resistance, leading to severe hypoxemia. Outcomes vary widely, ranging from complete recovery to death. This observational study will include term and preterm neonates admitted to the NICU with clinical and echocardiographic evidence of pulmonary hypertension. Clinical, laboratory, and echocardiographic parameters will be recorded to identify predictors of mortality and other adverse outcomes.
Study Type
OBSERVATIONAL
Enrollment
60
In-hospital mortality
Proportion of neonates with persistent pulmonary hypertension who die before hospital discharge.
Time frame: Up to 30 days
Duration of mechanical ventilation
Total number of days of invasive mechanical ventilation.
Time frame: Up to 30 days
Duration of oxygen therapy
Total number of days requiring supplemental oxygen.
Time frame: Up to 30 days
Use of sildenafil
Proportion of neonates who receive sildenafil therapy.
Time frame: Up to 30 days
Use of inotropes
Proportion of neonates who receive inotropic support
Time frame: Up to 30 days
Duration of NICU stay
Length of stay in the neonatal intensive care unit in days.
Time frame: Up to 30 days
Time to echocardiographic resolution
Number of days from diagnosis until echocardiographic resolution of pulmonary hypertension.
Time frame: Up to 30 days
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