EEG Abnormalities as Predictor of Outcome in Pediatric Encephalopathy

N/ANot Yet RecruitingNCT07825675

Assiut University147 enrolled

Overview

This prospective cohort study aims to evaluate the prognostic value of electroencephalographic (EEG) abnormalities in predicting poor clinical outcomes among children with encephalopathy admitted to Assiut University Children Hospital.

Pediatric encephalopathy has multiple etiologies and variable neurological outcomes. Early prognostic assessment is essential for clinical decision-making and family counseling. Electroencephalography (EEG) is a non-invasive tool that may help predict neurological outcome. This prospective observational study will include children aged 1 month to 18 years with clinical diagnosis of encephalopathy. EEG will be performed within the first 48 hours of admission. Neurological outcome will be assessed at hospital discharge using the Pediatric Cerebral Performance Category (PCPC) scale. A PCPC score of 1-2 will be considered good outcome and a score of ≥3 will be considered poor outcome.

Study Type

OBSERVATIONAL

Enrollment

147

Conditions

Encephalopathy Brain Diseases

Eligibility

Sex: ALLMin age: 1 MonthMax age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age from 1 month to 18 years * Clinical diagnosis of encephalopathy with altered level of consciousness * EEG performed within the first 48 hours of admission * Written informed consent from parents or legal guardians Exclusion Criteria: * Neonatal encephalopathy * Children with severe pre-existing neurological disability * Known epileptic patients * Incomplete clinical or EEG data

Outcomes

Primary Outcomes

Poor neurological outcome at hospital discharge

Proportion of children with poor neurological outcome defined as Pediatric Cerebral Performance Category (PCPC) score ≥3 at hospital discharge.

Time frame: at 30 days

Secondary Outcomes

Frequency of EEG abnormalities

Proportion of children with specific EEG abnormalities (diffuse background slowing, background suppression, burst suppression, absent reactivity, low-voltage activity, or electrographic seizures) recorded within the first 48 hours of admission.

Time frame: Within the first 48 hours of admission

Predictive performance of EEG abnormalities for poor outcome

Sensitivity, specificity, and predictive values of specific EEG abnormalities for poor neurological outcome (PCPC ≥3) at hospital discharge.

Time frame: at 30 days

Mortality

Proportion of children who die during hospital stay.

Time frame: at 30 days

Duration of PICU stay

Length of stay in the pediatric intensive care unit in days.

Time frame: at 30 days

Central Contacts

Esraa M Tamer, Resident

CONTACT

+20 11 58780125 Esraa.17289969@med.aun.edu.eg

Data from ClinicalTrials.gov

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