Effects of a Multi-Targeted Oral Supplement on Skin, Hair, Sleep, Energy, Cognition, Libido and Epigenetic Biological Clock Age

Inclusion Criteria: * Healthy adults aged 35 to 65 years (30% male : 70% female desired) * In generally good health, as determined by medical history questionnaire * Free from excessive hair, tattoos, dermatitis or scars on the test areas; males must attend each visit clean shaven, having shaved the day before the appointment * Able to read, understand and sign an informed consent agreement * Able to communicate well with study personnel and comply with study requirements * Hair at least 3 cm long, with no intention of substantial change to hair style * Participants on medicinal contraception: stable method for at least 3 months prior to baseline and willing not to change for the study duration * Women of childbearing potential: willing to use a reliable method of contraception * Participants on hormone replacement therapy: stable HRT for at least 6 months prior to baseline and willing not to change * Willing not to change regular food habits or commence any diet or nutritional change * Willing to refrain from taking any new dietary supplements other than study products * Willing to maintain usual lifestyle habits including exercise regimes * Willing to avoid medicated shampoo and conditioner * Willing to refrain from dermato-aesthetic facial procedures * Willing to refrain from chemical hair styling procedures (colour treatments permitted) * Willing to avoid excessive natural sunlight and other avoidable UV sources * Willing to remove facial piercings, earrings or jewellery prior to imaging * Willing to consent to use of their images by the Sponsor * Willing to have photographs taken to record any significant reactions * Willing to adhere to all study restrictions and requirements Exclusion Criteria: * \- Pregnant, breastfeeding, or of childbearing potential and not using reliable contraception * Consumed any food or health supplements (including vitamins, creatine, omegas, collagen) within the 3 months prior to baseline * Known allergy or hypersensitivity to any study product ingredient (products contain fish and coconut ingredients) * Known allergy or hypersensitivity to any dietary supplements * Any systemic condition (acute or chronic) or skin disorder including eczema, psoriasis, acne or diabetes (inactive skin disease for at least 6 months prior to baseline may be accepted at the Project Manager's discretion) * History of skin cancer with remission period below 5 years * Asthma or other chronic respiratory condition requiring therapy within the last 6 months * Any other systemic disease or medical or skin condition which in the opinion of the Project Manager, Study Doctor or Sponsor would affect ability to complete the study * Diagnosis of high cholesterol (current or previous) * Current treatment with cholesterol lowering medication * Family history of high cholesterol (first degree relative) * Diagnosis of ischaemic heart disease (current or previous) * Diagnosis of peripheral vascular disease or intermittent claudication * Diagnosis of stroke (current or previous) * Treatment (oral or topical) with tretinoin, isotretinoin or corticosteroids within the 6 months prior to baseline * Systemic steroids or anti-inflammatory treatments within the 6 months prior to baseline * Medications which may affect sampling or analysis, including metformin, anticoagulants, biological therapies, immunosuppressive or immunomodulating medication, chemotherapy, cytokine or anti-cytokine therapy * Surgical or non-surgical dermato-aesthetic facial procedures within the 6 months prior to baseline * Facial surgery (excluding dental) within the previous 6 months * Diagnosis of facial nerve damage * False eyelashes of any type on assessment days * Refusal to remove eyebrow make-up * Facial or ear piercings that cannot be removed for assessments * Low protein diet * Vegetarian or vegan diet (study products contain marine collagen and bovine gelatine) * Average alcohol consumption greater than 14 units per week * Night shift workers or irregular working hours interfering with regular sleep pattern * Intention to commence smoking cessation activities or alternative nicotine products during the study * Medically diagnosed insomnia * Active medically diagnosed alopecia or previous history * History of or high risk of blood borne infection (HIV, hepatitis B or C, AIDS) * History of problematic blood collections or negative experience during surgery