Moringa Leaf Powder for Prediabetes

Overview

The goal of this clinical trial was to learn whether Moringa oleifera leaf powder could lower fasting blood glucose in adults aged 25 to 55 years with prediabetes. It also assessed unwanted health effects during the intervention. The main questions it aimed to answer were: * Does taking Moringa oleifera leaf powder daily for 90 days lower fasting blood glucose compared with a placebo? * What unwanted health effects occur while participants take Moringa oleifera leaf powder or placebo? Researchers compared Moringa oleifera leaf powder with matching placebo capsules that contained no Moringa. Participants: * Were randomly assigned to receive Moringa oleifera leaf powder or placebo * Took six 400-mg capsules daily, as two capsules three times a day after meals, for 90 days * Measured and recorded fasting blood glucose at baseline and every 3 days during the study * Reported adherence and any unwanted health effects

This was a prospective, randomized, double-blind, placebo-controlled, parallel-group clinical trial conducted in a primary care setting in Bekasi, Indonesia. The study evaluated the effect of Moringa oleifera leaf powder on fasting blood glucose over 90 days in adults with prediabetes. Eligible participants were adults aged 25 to 55 years with fasting blood glucose levels of 100-125 mg/dL who had not used oral antidiabetic medication or insulin during the preceding 3 months. After providing informed consent, 114 participants were randomly assigned in a 1:1 ratio to the Moringa oleifera leaf powder group or the placebo group. Participants in the intervention group received 2,400 mg of Moringa oleifera leaf powder daily as six 400-mg capsules, taken as two capsules three times daily after meals for 90 days. Participants in the control group received matching microcrystalline cellulose placebo capsules according to the same schedule. Fasting blood glucose was measured at baseline and every 3 days through day 90. The primary objective was to compare the longitudinal pattern of fasting blood glucose between the two groups. Treatment adherence and unwanted health effects were also monitored throughout the study.