Efficacy of Temporal Interference-based Deep Brain Stimulation Combined With Conventional Rehabilitation Training for Lower Limb Motor Dysfunction After Stroke

Holden Functional grading assessment scale for walking

Holden functional classification of walking scale is a classic observational scale to assess the walking independence of patients

Time frame: Measurements were conducted before the intervention (baseline), on the ninth day after the intervention, and again after the intervention (3 weeks later).

Berg Balance Scale

For the balance function of the lower limbs, the Berg balance Scale was used. The scale contains 14 items covering tasks of varying difficulty ranging from balance in a sitting position to standing on one leg. Each item was scored on a 5-point scale from 0 to 4, with a total score ranging from 0 to 56. Higher scores indicate better balance.

Time frame: Measurements were conducted before the intervention (baseline), on the ninth day after the intervention, and again after the intervention (3 weeks later).

Modified Barthel Index

The Modified Barthel Index (MBI) was used to evaluate the activities of daily living of patients

Time frame: Measurements were conducted before the intervention (baseline), on the ninth day after the intervention, and again after the intervention (3 weeks later).

Motor evoked potential

TMS was used to detect the latency and amplitude of MEP of tibial anterior muscle and quadriceps femoris muscle on the affected and healthy sides, and to evaluate the cortical excitability of M1 area and the conduction function (conduction velocity and integrity) of corticospinal tract.

Time frame: Measurements were conducted before the intervention (baseline), on the ninth day after the intervention, and again after the intervention (3 weeks later).

Functional near-infrared spectroscopy imaging

Functional near-infrared spectroscopy (NIRS) was used to evaluate the brain function of the subjects in the resting state and task state (ankle dorsiflexion task), and to monitor the activation patterns of motor-related brain areas (such as primary motor cortex and supplementary motor area). The changes of functional connectivity of brain functional network were analyzed.

Time frame: Measurements were conducted before the intervention (baseline), on the ninth day after the intervention, and again after the intervention (3 weeks later).