Mechanical Power and Mortality in Mechanically Ventilated Adults

N/ANot Yet RecruitingNCT07836153

Zagazig University116 enrolled

Overview

This prospective observational cohort study aims to investigate the relationship between mechanical power during the first 72 hours of invasive mechanical ventilation and 28-day mortality in mechanically ventilated adult patients admitted to the Surgical Intensive Care Unit at Zagazig University Hospitals.

This prospective observational cohort study will enroll adult patients admitted to the Surgical Intensive Care Unit who require invasive mechanical ventilation. Mechanical power will be calculated during the first 72 hours of invasive mechanical ventilation using ventilatory parameters recorded during routine clinical care. Patient demographic and clinical characteristics, respiratory and ventilatory parameters, and relevant laboratory data will be recorded. Patients will be followed during their ICU stay, and 28-day mortality will be assessed as the primary outcome. The association between mechanical power and 28-day mortality will be evaluated using appropriate statistical analyses, including receiver operating characteristic (ROC) curve analysis to assess the predictive performance of mechanical power.

Study Type

OBSERVATIONAL

Enrollment

116

Conditions

Mechanical Ventilation Complication Ventilator Induced Lung Injury ARDS ICU Mortality (Survival Rate)

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age ≥18 years. * Both sexes. * Patients requiring invasive controlled mechanical ventilation in the ICU and expected to require mechanical ventilation for at least 72 hours. * Enrollment within the first 8 hours after initiation of invasive mechanical ventilation. * Acceptance and written informed consent from a first-degree relative. Exclusion Criteria: * Predominant spontaneous breathing or weaning modes during the first 48 hours. * Severe hemodynamic instability precluding standardized measurements. * Prolonged mechanical ventilation prior to ICU admission. * Pregnancy. * Chest trauma.

Locations (1)

Surgical Intensive Care Unit, Zagazig University Hospitals

Zagazig, Sharqia Province, Egypt

Outcomes

Primary Outcomes

28-Day Mortality

All-cause mortality within 28 days after initiation of invasive mechanical ventilation.

Time frame: At 28 days after initiation of invasive mechanical ventilation

Secondary Outcomes

Driving Pressure and Plateau Pressure

Correlation between mechanical power and driving pressure and plateau pressure at 24, 48, and 72 hours.

Time frame: At 24, 48, and 72 hours after initiation of invasive mechanical ventilation

Ventilator-Free Days

Number of ventilator-free days within the first 28 days.

Time frame: Through 28 days after initiation of invasive mechanical ventilation

ICU Length of Stay

Duration of stay in the intensive care unit

Time frame: From ICU admission until ICU discharge or death, through 28 days after initiation of invasive mechanical ventilation

Central Contacts

Tasneem Y Elshawadfy

CONTACT

201097684895 Tasneemelserafy206@gmail.com

Data from ClinicalTrials.gov

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