Safety and Efficacy of Carotid Artery Stenting Combined With Intermittent Hypoxia Intervention in Patients With Severe Internal Carotid Artery Stenosis

Inclusion Criteria: 1. Aged 18-70 years, BMI 18.5-24 kg/m², of any gender; treated in the Department of Neurology or Neurosurgery of our hospital and scheduled for carotid artery stenting. 2. Severe stenosis to occlusion (70-99%) of unilateral internal carotid artery (ICA) demonstrated by carotid ultrasound, Computed Tomography Angiography or Magnetic Resonance Angiography (per NASCET criteria). 3. No history of relevant drug allergy; tolerable to clopidogrel, aspirin and statins. 4. Good compliance, capable of cooperating with and completing brain MRI examinations. 5. For female subjects of child-bearing potential, a negative pregnancy test shall be confirmed prior to enrollment. 6. Stable vital signs with no significant abnormalities in liver and renal function tests. 7. Fully informed of the study content before trial participation and voluntarily providing written informed consent. Exclusion Criteria: 1. Progressive stroke. 2. Prior ipsilateral stroke with residual neurological deficits. 3. Severe dementia at enrollment. 4. Uncorrected severe cardiovascular diseases (e.g., myocardial infarction within 30 days prior to enrollment, severe heart failure). 5. Severe arrhythmia or chronic atrial fibrillation. 6. Pulmonary disease (Chronic Obstructive Pulmonary Disease，COPD), respiratory insufficiency, or requirement for oxygen supplementation. 7. Uncontrolled hypertension (systolic blood pressure ≥200 mmHg despite pharmacotherapy at enrollment). 8. Concurrent participation in another device or drug clinical trial. 9. Any condition that prevents angiographic assessment or renders percutaneous arterial puncture unsafe. 10. High-risk patients as defined by the Carotid Revascularization Endarterectomy vs. Stenting Trial (CREST). 11. Near-occlusion (90-99%) or occlusion of unilateral internal carotid artery (ICA) shown on carotid ultrasound, CTA or MRA (per NASCET criteria). 12. Other contraindications to intermittent hypoxia treatment.