Anti-microbial Effect of Acacia Arabica Extract on Gingival and Periodontal Health of Dental Patients

Umm Al-Qura University30 enrolled

Overview

This randomized clinical pilot study evaluated the short-term effects of Acacia arabica mouth rinse and paste as adjuncts to conventional oral hygiene in adults with plaque-induced gingivitis. Thirty systemically healthy participants aged 18-42 years were randomly allocated into three groups: a control group receiving conventional oral hygiene measures, an Acacia arabica mouth rinse group, and an Acacia arabica paste group. All participants received professional plaque removal and standardized oral hygiene instructions at baseline. Participants in the intervention groups additionally used either the Acacia arabica mouth rinse or paste twice daily for four weeks. Clinical assessments were performed at baseline, 2 weeks, and 4 weeks. The study evaluated changes in plaque index, gingival index, bleeding on probing, and salivary pH. The study aimed to determine whether Acacia arabica formulations could provide additional short-term benefits in plaque and gingival inflammation control compared with conventional oral hygiene measures alone.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Gingival and Periodontal Disease

Interventions

Eligibility

Sex: ALLMin age: 18 YearsMax age: 45 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Adults aged 18-42 years. * Diagnosis of plaque-induced gingivitis. * Presence of gingival inflammation without clinical attachment loss or -radiographic evidence of alveolar bone loss. * Presence of a minimum of 15 natural teeth per arch. * Willingness to participate and provide written informed consent. Exclusion Criteria: * Systemic diseases or medical conditions that may affect periodontal health. * Recent use of antibiotics or anti-inflammatory medications. * Presence of fixed orthodontic appliances/wires. * Current smoking. * Pregnancy or lactation. * Known allergy or hypersensitivity to herbal products.

Outcomes

Primary Outcomes

Change in Gingival Index (GI)

Gingival inflammation was assessed using the Gingival Index at baseline, 2 weeks, and 4 weeks. The index was used to evaluate changes in the severity of gingival inflammation during the intervention period. Lower scores indicate less gingival inflammation and better gingival health.

Time frame: Baseline, 2 weeks, and 4 weeks

Change in Plaque Index (PI)

Plaque accumulation was assessed using the Plaque Index at baseline, 2 weeks, and 4 weeks. The index was used to quantify changes in dental plaque accumulation during the intervention period. Lower scores indicate less plaque accumulation and better plaque control.