Lower Body Negative Pressure to Validate Physiological Monitors

Mayo Clinic50 enrolled

Overview

The purpose of this research is to test the accuracy of non-invasive physiological monitors while the body responds to different levels of lower body negative pressure (LBNP).

Study Type

INTERVENTIONAL

Allocation

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Physiological Stress

Interventions

Lower Body Negative Pressure with Noninvasive Physiological MonitoringDIAGNOSTIC_TEST

Participants will undergo a graded lower body negative pressure protocol using suction levels of 15, 30, 45, 60, 70, 80, 90, and 100 mmHg, each for up to 5 minutes or until presyncopal symptoms or other termination criteria occur. During the procedure, validated reference physiological measurements and investigational noninvasive monitor signals will be collected simultaneously.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 55 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Non-obese (BMI\<30) * Non-smokers * Free of any systemic diseases including hypertension, diabetes, coronary artery disease, neurologic disease, or any other major medical co-morbidity. * Women will be either surgically sterilized or non-pregnant as determined by a urine pregnancy test (within 48 hours of the study day) Exclusion Criteria: * Individuals taking GLP-1 medications or compounds known to affect responses of the autonomic nervous system to orthostatic stress (e.g., β-blockers) * Pregnant women

Locations (1)

Mayo Clinic

Rochester, Minnesota, United States

RECRUITING

Outcomes

Primary Outcomes

Arterial Oxygen Saturation During Lower Body Negative Pressure

Arterial oxygen saturation will be measured during lower body negative pressure using noninvasive physiological monitors