The goal of this retrospective observational study is to evaluate how long continuous renal replacement therapy (CRRT) circuits remain in use in adult intensive care unit patients and to describe how CRRT pressure measurements change over time. The main questions it aims to answer are: Are higher maximum and mean transmembrane pressure (TMP) values associated with longer CRRT circuit lifespan? Do time-normalized pressure trajectories and cumulative TMP burden differ between circuits with different lifespans? Do access pressure patterns influence the relationship between pressure measurements and circuit lifespan? Researchers will analyze archived CRRT device log files, including access pressure, filter pressure, effluent pressure, return pressure, and TMP measurements. No additional procedures, interventions, or study visits will be required. No directly identifiable patient information will be included in the analytical dataset.
Study Type
OBSERVATIONAL
Enrollment
162
This observational study involves no assigned intervention, treatment, device use, or change in clinical care. The study analyzes archived pressure recordings from CRRT device log files generated during routine clinical care. The analyzed variables include access pressure, filter pressure, effluent pressure, return pressure, and transmembrane pressure. CRRT circuit lifespan is evaluated retrospectively according to the time between the first and last valid pressure recording. No additional procedures or study-related interventions are performed.
Dr. Abdurrahman Yurtaslan Ankara Oncology Hospital
Yenimahalle, Ankara, Turkey (Türkiye)
Maximum Transmembrane Pressure Across CRRT Circuit Lifespan Categories
To compare maximum transmembrane pressure values among CRRT sessions grouped by circuit lifespan: less than 12 hours, 12 to less than 24 hours, 24 to less than 48 hours, and 48 hours or longer.
Time frame: From the first to the last valid pressure recording of each CRRT session
Initial 6-hour TMP slope
The initial 6-hour transmembrane pressure (TMP) slope will be calculated from the time-stamped TMP measurements obtained during the first 6 hours of each CRRT session. It will be expressed in mmHg per hour and will be evaluated as a secondary pressure-dynamics measure in relation to CRRT circuit lifespan and lifespan categories. Sessions without sufficient pressure data during the initial 6-hour period will be excluded from this specific analysis.
Time frame: During the first 6 hours of each CRRT session
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