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Results for “AK112”

74 trials

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Showing 20 of 74 results

Testing effectiveness (Phase 2)Not Yet RecruitingNCT07103447
What this trial is testing

Prospective Multicenter Single-arm Trial: AK112 + Nab-paclitaxel/Carboplatin Neoadjuvant for TNBC

Who this might be right for
Breast Cancer - Female
Shuangyue Liu 54
Testing effectiveness (Phase 2)Looking for participantsNCT07208773
What this trial is testing

YL201 and Ivonescimab (AK112) in Advanced Solid Tumors

Who this might be right for
Advanced Solid TumorsNon Small Cell Lung CancerSmall Cell Lung Cancer
MediLink Therapeutics (Suzhou) Co., Ltd. 260
Testing effectiveness (Phase 2)Not Yet RecruitingNCT06684873
What this trial is testing

A Multicenter, Single-arm, Open-label Study Evaluating the Safety and Efficacy of AK112 Combined With Chemotherapy as First-line Treatment for Non-squamous NSCLC Patients With BRAIN Metastases and Negative Driver Genes (IVO BRAIN)

Who this might be right for
NSCLCBrain Metastasases
Sun Yat-sen University 55
Testing effectiveness (Phase 2)Looking for participantsNCT05227664
What this trial is testing

AK117/AK112 in Metastatic Triple-Negative Breast Cancer

Who this might be right for
Metastatic Triple-negative Breast CancerLocally Advanced Triple-negative Breast Cancer
Akeso 120
Testing effectiveness (Phase 2)Looking for participantsNCT05846867
What this trial is testing

A Phase Ib/II Clinical Study on AK112 Combined or Not Combined With AK119 in pMMR/MSS Colorectal Cancer

Who this might be right for
Colorectal Cancer
Akeso 170
Testing effectiveness (Phase 2)Not Yet RecruitingNCT06196775
What this trial is testing

Cadonilimab Combined With AK112 as Second-line Therapy in Patients With Advanced Hepatocellular Carcinoma

Who this might be right for
Hepatocellular Carcinoma
Harbin Medical University 36
Testing effectiveness (Phase 2)Active Not RecruitingNCT05382442
What this trial is testing

AK112 With or Without AK117 in Metastatic Colorectal Cancer

Who this might be right for
Metastatic Colorectal Cancer
Akeso 254
Not applicableEnrolling By InvitationNCT06936488
What this trial is testing

A Prospective, Single Arm, Open Label, Phase II Clinical Study on the Efficacy and Safety of Ivonescimab (AK112) Combined With TAS-102 in the Treatment of Refractory MSS/pMMR Advanced Colorectal Cancer

Who this might be right for
MSS/pMMR Type Metastatic Colorectal Adenocarcinoma Patients
Huai'an First People's Hospital 35
Testing effectiveness (Phase 2)Looking for participantsNCT06491472
What this trial is testing

Ivonescimab(AK112/SMT112) in Combination With Stereotactic Body Radiation Therapy and Chemotherapy in Patients With Pancreatic Cancer

Who this might be right for
Pancreatic Cancer
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology 36
Early research (Phase 1)Study completedNCT05116007
What this trial is testing

Anti-PD-1 and VEGF Bispecific Antibody AK112 in Combination With Chemotherapy in Patients With ES-SCLC

Who this might be right for
SCLC, Extensive Stage
Akeso 35
Testing effectiveness (Phase 2)Not Yet RecruitingNCT06472895
What this trial is testing

AK112 Monotherapy in Advanced/Metastatic Renal Cell Carcinoma

Who this might be right for
Renal Cell Carcinoma
Peking University Cancer Hospital & Institute 30
Testing effectiveness (Phase 2)Study completedNCT04597541
What this trial is testing

AK112 for Advanced Solid Tumors

Who this might be right for
Solid Tumor, Adult
Akeso 59
Not applicableNot Yet RecruitingNCT06766591
What this trial is testing

Ivonescimab Combined With Chemotherapy for the Treatment of Leptomeningeal Metastases Failed to EGFR-TKIs

Who this might be right for
NSCLCChemotherapyLeptomeningeal Metastases+2 more
Jiangsu Province Nanjing Brain Hospital 36
Testing effectiveness (Phase 2)Looking for participantsNCT07385001
What this trial is testing

A Prospective, Multicenter, Phase Ib/II Trial of Ivonescimab (AK112) Combined With Albumin-Paclitaxel and Cisplatin as Neoadjuvant Therapy for ESCC

Who this might be right for
Esophageal Squamous Cell CarcinomaIvonescimabNeoadjuvant
Tang-Du Hospital 45
Testing effectiveness (Phase 2)Study completedNCT04870177
What this trial is testing

Study of AK112 in the Treatment of Advanced Gynecological Tumors

Who this might be right for
Gynecologic CancerCancer MetastaticOvarian Neoplasms+2 more
Akeso 53
Large-scale testing (Phase 3)Looking for participantsNCT06601335
What this trial is testing

AK112 Plus AK117 Versus Pembrolizumab in Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma (R/M HNSCC)

Who this might be right for
Head and Neck Squamous Cell Carcinoma
Akeso 510
Testing effectiveness (Phase 2)Looking for participantsNCT06489197
What this trial is testing

AK112 Combined With Chemotherapy as the First-line Treatment in Advanced Esophageal Squamous Cell Carcinoma Patients

Who this might be right for
ESCCAdvanced Esophageal Squamous Cell Carcinoma
Tianjin Medical University Cancer Institute and Hospital 30
Testing effectiveness (Phase 2)Looking for participantsNCT05904379
What this trial is testing

AK112 and AK104 With or Without Chemotherapy in Advanced Non-small Cell Lung Cancer

Who this might be right for
Advanced Non-small-cell Lung Cancer
Akeso 233
Testing effectiveness (Phase 2)Not Yet RecruitingNCT06537011
What this trial is testing

AK112 Plus AP Regimen for Operable Locally Advanced Head and Neck Squamous Cell Carcinoma

Who this might be right for
Neoadjuvant Therapy of Operable Locally Advanced Head and Neck Squamous Cell Carcinoma
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology 36
Testing effectiveness (Phase 2)UnknownNCT05689853
What this trial is testing

Study of AK119 Combined With AK112 in Patients With Advanced Solid Tumors

Who this might be right for
Solid Tumor, Adult
Akeso 87
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