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Results for “AK112”

77 trials

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Showing 20 of 77 results

Large-scale testing (Phase 3)Active Not RecruitingNCT05840016
What this trial is testing

AK112 in Combination With Chemotherapy in Advanced Squamous Non-Small Cell Lung Cancer

Who this might be right for
Advanced Squamous Non Small Cell Lung Cancer
Akeso 532
Testing effectiveness (Phase 2)Active Not RecruitingNCT05247684
What this trial is testing

AK112 Neoadjuvant/Adjuvant Treatment for Resectable NSCLC

Who this might be right for
Resectable Non-small Cell Lung Cancer
Akeso 90
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07103447
What this trial is testing

Prospective Multicenter Single-arm Trial: AK112 + Nab-paclitaxel/Carboplatin Neoadjuvant for TNBC

Who this might be right for
Breast Cancer - Female
Shuangyue Liu 54
Testing effectiveness (Phase 2)Looking for participantsNCT07385001
What this trial is testing

A Prospective, Multicenter, Phase Ib/II Trial of Ivonescimab (AK112) Combined With Albumin-Paclitaxel and Cisplatin as Neoadjuvant Therapy for ESCC

Who this might be right for
Esophageal Squamous Cell CarcinomaIvonescimabNeoadjuvant
Tang-Du Hospital 45
Testing effectiveness (Phase 2)Study completedNCT05432492
What this trial is testing

AK112 in Patients With Unresectable Hepatocellular Carcinoma (HCC)

Who this might be right for
Hepatocellular Carcinoma
Akeso 40
Large-scale testing (Phase 3)Looking for participantsNCT06601335
What this trial is testing

AK112 Plus AK117 Versus Pembrolizumab in Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma (R/M HNSCC)

Who this might be right for
Head and Neck Squamous Cell Carcinoma
Akeso 510
Testing effectiveness (Phase 2)Active Not RecruitingNCT06646055
What this trial is testing

AK112 and Cadonilimab Combined With Chemotherapy for 1L Treatment of Metastatic Pancreatic Cancer

Who this might be right for
Metastatic Pancreatic Ductal Adenocarcinoma
Akeso 110
Testing effectiveness (Phase 2)Looking for participantsNCT07114315
What this trial is testing

AK130 in Combination With AK112 for the Treatment of Advanced Pancreatic Cancer

Who this might be right for
Pancreatic Cancer
Akeso 160
Testing effectiveness (Phase 2)Looking for participantsNCT06938321
What this trial is testing

AK130 in Combination With AK112 for the Treatment of Advanced Biliary Tract Cancer

Who this might be right for
Biliary Tract Cancer
Akeso 135
Testing effectiveness (Phase 2)Not Yet RecruitingNCT06537011
What this trial is testing

AK112 Plus AP Regimen for Operable Locally Advanced Head and Neck Squamous Cell Carcinoma

Who this might be right for
Neoadjuvant Therapy of Operable Locally Advanced Head and Neck Squamous Cell Carcinoma
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology 36
Not applicableEnrolling By InvitationNCT06936488
What this trial is testing

A Prospective, Single Arm, Open Label, Phase II Clinical Study on the Efficacy and Safety of Ivonescimab (AK112) Combined With TAS-102 in the Treatment of Refractory MSS/pMMR Advanced Colorectal Cancer

Who this might be right for
MSS/pMMR Type Metastatic Colorectal Adenocarcinoma Patients
Huai'an First People's Hospital 35
Testing effectiveness (Phase 2)Looking for participantsNCT06769295
What this trial is testing

A Phase II Study of AK112 (PD1/VEGF Bispecific) in Combination with Chemotherapy in Patients with NSCLC

Who this might be right for
Lung Cancer, Non-Small Cell
Sichuan University 28
Testing effectiveness (Phase 2)Looking for participantsNCT06560112
What this trial is testing

An Exploratory, Multi-cohort Phase II Study of Combination Therapy With AK104 and AK112 for Recurrent Ovarian Cancer

Who this might be right for
Recurrent Ovarian Cancer
Akeso 172
Testing effectiveness (Phase 2)Not Yet RecruitingNCT06391008
What this trial is testing

Immunosensitized Radiotherapy Combined With Evoximab (AK112) and Chemotherapy Neoadjuvant Therapy for Stage II-III Non-small Cell Lung Cancer

Who this might be right for
Stereotactic Radiotherapy; Evoximab (AK112); New Adjuvant Therapy for Non-small Cell Lung Cancer
The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School 44
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07021950
What this trial is testing

AK112 Plus FOLFIRI Versus Bevacizumab Plus FOLFIRI as Second-line Treatment of MSS/pMMR Metastatic Colorectal Cancer

Who this might be right for
Colorectal CancerIvonescimab
Sun Yat-sen University 130
Testing effectiveness (Phase 2)Not Yet RecruitingNCT06196814
What this trial is testing

AK112 Plus Platinum-based Chemotherapy for EGFR/ALK/ROS1 Positve NSCLC

Who this might be right for
Efficacy
Hunan Province Tumor Hospital 150
Testing effectiveness (Phase 2)Looking for participantsNCT06951646
What this trial is testing

CtDNA-MRD Guided Escalation of Ivonescimab and Docetaxel in Advanced NSCLC With Long-Term Responses to First-line Immunotherapy (CR1STAL-Adaptive)

Who this might be right for
Non Small Cell Lung CancerImmune Checkpoint Inhibitors (ICIs)
Second Xiangya Hospital of Central South University 70
Testing effectiveness (Phase 2)Looking for participantsNCT06491472
What this trial is testing

Ivonescimab(AK112/SMT112) in Combination With Stereotactic Body Radiation Therapy and Chemotherapy in Patients With Pancreatic Cancer

Who this might be right for
Pancreatic Cancer
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology 36
Testing effectiveness (Phase 2)Not Yet RecruitingNCT06472895
What this trial is testing

AK112 Monotherapy in Advanced/Metastatic Renal Cell Carcinoma

Who this might be right for
Renal Cell Carcinoma
Peking University Cancer Hospital & Institute 30
Early research (Phase 1)Not Yet RecruitingNCT06424626
What this trial is testing

A Trial of AK104 or AK112 in Combination With Axitinib in Patients With Metastatic Mucosal Melanoma

Who this might be right for
MelanomaMucosal MelanomaMetastatic Melanoma
Peking University Cancer Hospital & Institute 60
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