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Results for “AK112”

86 trials

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Showing 20 of 86 results

Early research (Phase 1)Study completedNCT04047290
What this trial is testing

AK112, a PD-1/VEGF Bispecific Antibody, for Advanced Solid Tumors

Who this might be right for
Neoplasms Malignant
Akesobio Australia Pty Ltd 80
Testing effectiveness (Phase 2)Enrolling By InvitationNCT07488572
What this trial is testing

Safety and Efficacy of Yiwoxidan Anti (AK112) Monotherapy in Patients With Metastatic Renal Clear Cell Carcinoma Who Are Intolerant to TKI Treatment: a Prospective, Single Arm, Phase II Clinical Study

Who this might be right for
Renal Cell Carcinoma (RCC)Metastatic Clear Cell Renal Cell Carcinoma
Sun Yat-sen University 60
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07712094
What this trial is testing

AK112 Combination Therapy as First Line Treatment for Metastatic Digestive System Neuroendocrine Cancer

Who this might be right for
Neuroendocrine Cancer
Tianjin Medical University Cancer Institute and Hospital 56
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07244978
What this trial is testing

Neoadjuvant Ivonescimab（AK112） Combined With Chemotherapy in Patients With Resectable Esophageal Squamous Cell Carcinoma

Who this might be right for
Esophageal Squamous Cell CarcinomaNeoadjuvant Therapy
Second Affiliated Hospital, Zhejiang University, School of Medicine 49
Testing effectiveness (Phase 2)Active Not RecruitingNCT04736823
What this trial is testing

A Trial of AK112 (PD1/VEGF Bispecific) in Combination With Chemotherapy in Patients With NSCLC

Who this might be right for
NSCLC
Akeso 265
Large-scale testing (Phase 3)Looking for participantsNCT06601335
What this trial is testing

AK112 Plus AK117 Versus Pembrolizumab in Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma (R/M HNSCC)

Who this might be right for
Head and Neck Squamous Cell Carcinoma
Akeso 510
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07357220
What this trial is testing

AK112 in Combination With VG2025 in Colorectal Cancer With Liver Metastases

Who this might be right for
Colorectal Cancer With Hepatic Metastases
Akeso 72
Large-scale testing (Phase 3)Looking for participantsNCT07010263
What this trial is testing

AK112 as Consolidation Treatment for Patients With Limited Stage Small-cell Lung Cancer Who Have Not Progressed Following Concurrent Chemoradiation Therapy

Who this might be right for
Small Cell Lung Cancer
Akeso 560
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07021950
What this trial is testing

AK112 Plus FOLFIRI Versus Bevacizumab Plus FOLFIRI as Second-line Treatment of MSS/pMMR Metastatic Colorectal Cancer

Who this might be right for
Colorectal CancerIvonescimab
Sun Yat-sen University 130
Testing effectiveness (Phase 2)Looking for participantsNCT06875076
What this trial is testing

Multicenter Single-Arm Study of Ivonescimab (AK112) Combined with Chemotherapy in Pretreated Pleural Mesothelioma

Who this might be right for
Pretreated Pleural Mesothelioma
The First Hospital of Jilin University 25
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07767994
What this trial is testing

AK112 Combined With GAP Conversion Therapy for Locally Advanced Gallbladder Cancer

Who this might be right for
Gallbladder Cancer
First Affiliated Hospital Xi'an Jiaotong University 22
Testing effectiveness (Phase 2)Study completedNCT05432492
What this trial is testing

AK112 in Patients With Unresectable Hepatocellular Carcinoma (HCC)

Who this might be right for
Hepatocellular Carcinoma
Akeso 40
Testing effectiveness (Phase 2)Looking for participantsNCT07385001
What this trial is testing

A Prospective, Multicenter, Phase Ib/II Trial of Ivonescimab (AK112) Combined With Albumin-Paclitaxel and Cisplatin as Neoadjuvant Therapy for ESCC

Who this might be right for
Esophageal Squamous Cell CarcinomaIvonescimabNeoadjuvant
Tang-Du Hospital 45
Testing effectiveness (Phase 2)Active Not RecruitingNCT05846867
What this trial is testing

A Phase Ib/II Clinical Study on AK112 Combined or Not Combined With AK119 in pMMR/MSS Colorectal Cancer

Who this might be right for
Colorectal Cancer
Akeso 170
Testing effectiveness (Phase 2)Looking for participantsNCT07114315
What this trial is testing

AK130 in Combination With AK112 for the Treatment of Advanced Pancreatic Cancer

Who this might be right for
Pancreatic Cancer
Akeso 160
Testing effectiveness (Phase 2)Active Not RecruitingNCT05227664
What this trial is testing

AK117/AK112 in Metastatic Triple-Negative Breast Cancer

Who this might be right for
Metastatic Triple-negative Breast CancerLocally Advanced Triple-negative Breast Cancer
Akeso 120
Testing effectiveness (Phase 2)Study completedNCT06478043
What this trial is testing

Investigate the Efficacy and Safety of Ivonescimab Combined With Irinotecan Liposome as Second-line Regimen for SCLC

Who this might be right for
Small-cell Lung Cancer
Zhejiang Cancer Hospital 60
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07086326
What this trial is testing

A Phase II Randomized Trial of Neoadjuvant Ivonescimab or Penpulimab Plus Chemotherapy in Resectable NSCLC

Who this might be right for
NSCLCNeoadjuvant TherapyImmunotherapy+2 more
Yang Fan, MD 164
Early research (Phase 1)Enrolling By InvitationNCT06424626
What this trial is testing

A Trial of AK104 or AK112 in Combination With Axitinib in Patients With Metastatic Mucosal Melanoma

Who this might be right for
MelanomaMucosal MelanomaMetastatic Melanoma
Peking University Cancer Hospital & Institute 60
Testing effectiveness (Phase 2)Not Yet RecruitingNCT06196814
What this trial is testing

AK112 Plus Platinum-based Chemotherapy for EGFR/ALK/ROS1 Positve NSCLC

Who this might be right for
Efficacy
Hunan Province Tumor Hospital 150
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