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Results for “AKT”

142 trials

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Showing 20 of 142 results

Early research (Phase 1)Ended earlyNCT04586270
What this trial is testing

TAS0612 in Participants With Advanced or Metastatic Solid Tumor Cancer

Who this might be right for
Advanced or Metastatic Solid Tumors
Taiho Oncology, Inc. 47
Not applicableEnded earlyNCT05571670
What this trial is testing

Bile Acids in Acute Insulin Resistance

Who this might be right for
PI3K Gene MutationAKT Gene MutationMTOR Gene Mutation+2 more
Columbia University 3
Early research (Phase 1)Study completedNCT00920257
What this trial is testing

A Phase I, Open-Label, First-Time-In-Human Study of the Oral AKT Inhibitor GSK2141795

Who this might be right for
Cancer
GlaxoSmithKline 77
Testing effectiveness (Phase 2)Ended earlyNCT02644122
What this trial is testing

SF1126 in Recurrent or Progressive SCCHN and Mutations in PIK3CA Gene and/or PI-3 Kinase Pathway Genes

Who this might be right for
Metastatic Squamous Neck Cancer With Occult Primary Squamous Cell Carcinoma
Ezra Cohen 1
Not applicableUnknownNCT04058912
What this trial is testing

PTEN-AKT-FOXO3 Gene Expression Relation With Low-ovarian Reserve in Endometriomas

Who this might be right for
Ovarian Reserve, Endometrioma, PTEN-AKT-FOXO3 Gene Expression
Uludag University 60
Testing effectiveness (Phase 2)Study completedNCT01258998
What this trial is testing

Study of Akt Inhibitor MK2206 in Patients With Relapsed Lymphoma

Who this might be right for
Adult Nasal Type Extranodal NK/T-cell LymphomaAnaplastic Large Cell LymphomaAngioimmunoblastic T-cell Lymphoma+33 more
National Cancer Institute (NCI) 60
Testing effectiveness (Phase 2)Active Not RecruitingNCT04439123
What this trial is testing

Testing AZD5363 as a Potential Targeted Treatment in Cancers With AKT Genetic Changes (MATCH-Subprotocol Y)

Who this might be right for
Advanced LymphomaAdvanced Malignant Solid NeoplasmHematopoietic and Lymphoid Cell Neoplasm+3 more
National Cancer Institute (NCI) 35
Early research (Phase 1)Looking for participantsNCT07343960
What this trial is testing

A Phase I Study to Investigate the Pharmacokinetics and Safety of Capivasertib in Participants With Moderate Hepatic Impairment

Who this might be right for
Moderate Hepatic Impairment
AstraZeneca 20
Early research (Phase 1)Study completedNCT01428492
What this trial is testing

Ph 1b Study to Evaluate GSK2110183 in Combination With Bortezomib and Dexamethasone in Subjects With Multiple Myeloma

Who this might be right for
Multiple Myeloma
Novartis 90
Not applicableNo Longer AvailableNCT03317366
What this trial is testing

Expanded Access to Provide ARQ 092 for the Treatment of Overgrowth Diseases and/or Vascular Anomalies

Who this might be right for
Proteus SyndromePIK3CA-Related Overgrowth Spectrum (PROS)Growth Disorders
ArQule, Inc., a subsidiary of Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc. (Rahway, NJ USA)
Not applicableWithdrawnNCT05597982
What this trial is testing

How Do Structural Social Determinants of Health Affect AKT-MP and Outcomes

Who this might be right for
Kidney DiseasesSocial Determinants of Health
University of New Mexico
Not applicableStudy completedNCT05054166
What this trial is testing

Efficacy of Everolimus-containing Chemotherapy in HER2- mBC Patients With PI3K/AKT/mTOR Mutations Study

Who this might be right for
Breast CancerPI3K/AKT/mTOR Pathway MutationEverolimus
Zhejiang Cancer Hospital 14
Very early researchStudy completedNCT01513356
What this trial is testing

Pharmacodynamic Study of BKM120 in Breast Cancer

Who this might be right for
Breast Cancer
Sofia Perea, Director Clinical Trials Unit. 20
Testing effectiveness (Phase 2)Temporarily pausedNCT05554380
What this trial is testing

Study of Chemotherapy Plus Ipatasertib for People With Solid Tumors With PTEN/AKT Mutations, A ComboMATCH Treatment Trial

Who this might be right for
Locally Advanced Malignant Solid NeoplasmMetastatic Malignant Solid NeoplasmUnresectable Malignant Solid Neoplasm
National Cancer Institute (NCI) 33
Early research (Phase 1)Study completedNCT01266954
What this trial is testing

An Open Label Study To Investigate the Pharmacokinetics and Pharmacodynamics of Repeat Escalating Doses of the Oral AKT Inhibitor GSK2141795 by 18F FDG PET Analysis in Subjects With Ovarian Cancer

Who this might be right for
Solid Tumours
GlaxoSmithKline 36
Large-scale testing (Phase 3)UnknownNCT03580239
What this trial is testing

Everolimus in Castrated Resistant Prostate Cancer(CRPC)Patients With PI3K-AKT-mTOR Signaling Pathway Deficiency

Who this might be right for
Prostate Cancer
Tianjin Medical University Second Hospital 120
Testing effectiveness (Phase 2)Study completedNCT01604772
What this trial is testing

Akt Inhibitor MK2206 in Treating Patients With Progressive, Recurrent, or Metastatic Adenoid Cyst Carcinoma

Who this might be right for
Recurrent Oral Cavity Adenoid Cystic CarcinomaRecurrent Salivary Gland CarcinomaSalivary Gland Adenoid Cystic Carcinoma+6 more
National Cancer Institute (NCI) 16
Early research (Phase 1)Study completedNCT01353781
What this trial is testing

Open Label Phase 1 Study in Japan for Patient With Advanced Solid Malignancies

Who this might be right for
Advanced Solid MalignancyAdvanced Solid Tumor
AstraZeneca 39
Testing effectiveness (Phase 2)Study completedNCT01210911
What this trial is testing

Metformin Combined With Chemotherapy for Pancreatic Cancer

Who this might be right for
Locally Advanced Pancreatic CancerMetastatic Pancreatic Cancer
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) 120
Early research (Phase 1)Ended earlyNCT00493818
What this trial is testing

Open-label Study to Investigate the Safety, Tolerability, PK, and Pharmacodynamics of the AKT Inhibitor GSK690693

Who this might be right for
Cancer
GlaxoSmithKline 70
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