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Results for “AKT”

146 trials

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Showing 20 of 146 results

Early research (Phase 1)Study completedNCT00694837
What this trial is testing

Study With Nelfinavir and Combined Radiochemotherapy for Glioblastoma

Who this might be right for
Glioblastoma
Maastricht Radiation Oncology 6
Early research (Phase 1)Study completedNCT01245205
What this trial is testing

Akt Inhibitor MK2206 in Combination With Lapatinib Ditosylate in Patients With Advanced or Metastatic Solid Tumors or Breast Cancer

Who this might be right for
HER2-positive Breast CancerMale Breast CancerRecurrent Breast Cancer+4 more
National Cancer Institute (NCI) 28
Early research (Phase 1)WithdrawnNCT01240928
What this trial is testing

MK-2206+Endocrine Therapy in Patients With Hormone Receptor-Positive Breast Cancer

Who this might be right for
Metastatic Breast Cancer
Vanderbilt-Ingram Cancer Center
Large-scale testing (Phase 3)Active Not RecruitingNCT05348577
What this trial is testing

Study of Capivasertib + Docetaxel vs Placebo + Docetaxel as Treatment for Metastatic Castration Resistant Prostate Cancer (mCRPC)

Who this might be right for
Prostate Cancer
AstraZeneca 1,035
Testing effectiveness (Phase 2)Active Not RecruitingNCT05554380
What this trial is testing

Study of Chemotherapy Plus Ipatasertib for People With Solid Tumors With PTEN/AKT Mutations, A ComboMATCH Treatment Trial

Who this might be right for
Locally Advanced Malignant Solid NeoplasmMetastatic Malignant Solid NeoplasmUnresectable Malignant Solid Neoplasm
National Cancer Institute (NCI) 33
Early research (Phase 1)Ended earlyNCT00493818
What this trial is testing

Open-label Study to Investigate the Safety, Tolerability, PK, and Pharmacodynamics of the AKT Inhibitor GSK690693

Who this might be right for
Cancer
GlaxoSmithKline 70
Not applicableLooking for participantsNCT07646171
What this trial is testing

EVERST- Everolimus After Alpelisib in Women With Hormone Receptor-positive (HR+) Metastatic Breast Cancer (MBC)

Who this might be right for
Hormone Receptor Positive Breast Cancer
Tel-Aviv Sourasky Medical Center 19
Large-scale testing (Phase 3)Active Not RecruitingNCT06764186
What this trial is testing

A Phase IIIB Study to Evaluate the Use of Capivasertib in Combination With Fulvestrant in Patients With Advanced Breast Cancer Who Have Relapsed/Progressed on ET and CDK4/6 Inhibitor Reflecting Real World Clinical Practice in Spain

Who this might be right for
Locally Advanced or Metastatic Breast Cancer
AstraZeneca 101
Testing effectiveness (Phase 2)Study completedNCT01277757
What this trial is testing

Akt Inhibitor MK2206 in Treating Patients With Advanced Breast Cancer

Who this might be right for
Recurrent Breast CarcinomaStage IIIB Breast CancerStage IIIC Breast Cancer+1 more
National Cancer Institute (NCI) 30
Testing effectiveness (Phase 2)Ended earlyNCT01980277
What this trial is testing

Phase Ib/II Study of LY2780301 in Combination With Weekly PACLITAXEL in HER2-metastatic Breast Cancer

Who this might be right for
Breast Cancer
Institut Paoli-Calmettes 68
Testing effectiveness (Phase 2)Study completedNCT00957853
What this trial is testing

Preoperative Treatment With Cetuximab and/or IMC-A12

Who this might be right for
Head and Neck Squamous Cell Carcinoma
M.D. Anderson Cancer Center 16
Testing effectiveness (Phase 2)Ended earlyNCT02644122
What this trial is testing

SF1126 in Recurrent or Progressive SCCHN and Mutations in PIK3CA Gene and/or PI-3 Kinase Pathway Genes

Who this might be right for
Metastatic Squamous Neck Cancer With Occult Primary Squamous Cell Carcinoma
Ezra Cohen 1
Testing effectiveness (Phase 2)Study completedNCT01395004
What this trial is testing

Test the Ability of and Safety of GSK2110183 in Treating Langerhans Cell Histiocytosis

Who this might be right for
Langerhans Cell Histiocytosis
GlaxoSmithKline 17
Testing effectiveness (Phase 2)Study completedNCT01294306
What this trial is testing

MK2206 and Erlotinib Hydrochloride in Treating Patients With Advanced Non-Small Cell Lung Cancer Who Have Progressed After Previous Response to Erlotinib Hydrochloride Therapy

Who this might be right for
Adenosquamous Lung CarcinomaBronchioloalveolar CarcinomaLarge Cell Lung Carcinoma+3 more
National Cancer Institute (NCI) 80
Early research (Phase 1)Study completedNCT02240212
What this trial is testing

Study of Afuresertib Combined With Paclitaxel in Gastric Cancer

Who this might be right for
Cancer
Novartis Pharmaceuticals 29
Early research (Phase 1)Study completedNCT04253561
What this trial is testing

Ipatasertib + Pertuzumab +Trastuzumab in Advanced HER2+ PI3KCA-mutant Breast Cancer Patients

Who this might be right for
Metastatic Breast Cancer
SOLTI Breast Cancer Research Group 17
Not applicableActive Not RecruitingNCT04666545
What this trial is testing

Multidisciplinary Support To Access Living Donor Kidney Transplant-Pilot

Who this might be right for
Living Donor Kidney Transplantation
University of Alberta 38
Testing effectiveness (Phase 2)Study completedNCT01260701
What this trial is testing

Akt Inhibitor MK2206 in Treating Patients With Advanced Gastric or Gastroesophageal Junction Cancer

Who this might be right for
Adenocarcinoma of the Gastroesophageal JunctionDiffuse Gastric AdenocarcinomaGastric Intestinal Type Adenocarcinoma+2 more
National Cancer Institute (NCI) 75
Testing effectiveness (Phase 2)Ended earlyNCT01907815
What this trial is testing

Trametinib and Akt Inhibitor GSK2141795 in Treating Patients With Acute Myeloid Leukemia

Who this might be right for
Recurrent Adult Acute Myeloid LeukemiaUntreated Adult Acute Myeloid Leukemia
National Cancer Institute (NCI) 24
Testing effectiveness (Phase 2)Ended earlyNCT01466868
What this trial is testing

Study of MK 2206 in Patients With Relapsed or Refractory Diffuse Large B Cell Lymphoma

Who this might be right for
Diffuse Large B Cell Lymphoma
Centre Leon Berard 22
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