Large-scale testing (Phase 3)Ended earlyNCT06111014What this trial is testingContinuation Study for LatozinemabWho this might be right forNeurodegenerative Diseases Alector Inc. 17
Not applicableLooking for participantsNCT06595212What this trial is testingGenetics and Environment iNtersection In the ALS-FTD Spectrum: an Italian Twins Cohort studY With a Multi-Omics ApproachWho this might be right forALSFTD Azienda Ospedaliero-Universitaria di Modena 45
Not applicableLooking for participantsNCT04363684What this trial is testingARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD)Who this might be right forFrontotemporal Lobar Degeneration (FTLD)Progressive Supranuclear Palsy (PSP)Corticobasal Degeneration (CBD)+11 more Mayo Clinic 2,100
Not applicableLooking for participantsNCT06528964What this trial is testingProteinopathies Expression in Skin of Neurodegenerative DisordersWho this might be right forAlzheimer DiseaseFrontotemporal DementiaParkinson Disease+3 more Universidad Autonoma de San Luis Potosí 40
Not applicableStudy completedNCT05852405What this trial is testingClinical Characteristics, Natural History, Health Care Measures, and Genetic Screening in Patients With ALSWho this might be right forMotor Neuron Disease, Amyotrophic Lateral Sclerosis Ambulanzpartner Soziotechnologie APST GmbH 2,000
Not applicableStudy completedNCT02365922What this trial is testingAdvancing Research and Treatment for Frontotemporal Lobar Degeneration (ARTFL)Who this might be right forFTLDProgressive Supranuclear Palsy (PSP)Frontotemporal Dementia (FTD)+9 more University of California, San Francisco 1,489
Testing effectiveness (Phase 2)Active Not RecruitingNCT04220021What this trial is testingSafety and Therapeutic Potential of the FDA-approved Drug Metformin for C9orf72 ALS/FTDWho this might be right forC9orf72 Amyotrophic Lateral Sclerosis (ALS)Frontotemporal Dementia University of Florida 41
Testing effectiveness (Phase 2)Study completedNCT05189106What this trial is testingNeurodegenerative Alzheimer's Disease and Amyotrophic Lateral Sclerosis (NADALS) Basket TrialWho this might be right forAmyotrophic Lateral SclerosisAlzheimer DiseaseMild Cognitive Impairment Massachusetts General Hospital 17
Testing effectiveness (Phase 2)Ended earlyNCT04931862What this trial is testingStudy of WVE-004 in Patients With C9orf72-associated Amyotrophic Lateral Sclerosis (ALS) or Frontotemporal Dementia (FTD)Who this might be right forALSFTD Wave Life Sciences Ltd. 35
Not applicableLooking for participantsNCT00317616What this trial is testingThe Pre-symptomatic Familial Amyotrophic Lateral Sclerosis (Pre-fALS) StudyWho this might be right forAmyotrophic Lateral Sclerosis University of Miami 500
Very early researchLooking for participantsNCT06891716What this trial is testing[18F]ACI-19626 PET in TDP-43 ProteinopathiesWho this might be right forFrontotemporal Dementia (FTD)Amyotrophic Lateral Sclerosis (ALS)TDP-43 Proteinopathies+2 more AC Immune SA 45
Not applicableLooking for participantsNCT07509125What this trial is testingUltra-High Resolution PET in Aging, Neurodegeneration and Psychotic DisordersWho this might be right forAlzheimer Dementia (AD)ALS - Amyotrophic Lateral SclerosisParkinson s Disease+7 more Universitaire Ziekenhuizen KU Leuven 300
Not applicableLooking for participantsNCT03865420What this trial is testingAmyotrophic Lateral Sclerosis (ALS) Families ProjectWho this might be right forALS Columbia University 300
Not applicableWithdrawnNCT01459302What this trial is testingGenetic Study of Familial and Sporadic ALS/Motor Neuron Disease, Miyoshi Myopathy and Other Neuromuscular DisordersWho this might be right forAmyotrophic Lateral SclerosisFrontotemporal DementiaPLS+7 more University of Massachusetts, Worcester
Not applicableLooking for participantsNCT02964637What this trial is testingDiagnosing Frontotemporal Lobar DegenerationWho this might be right forCorticobasal SyndromeProgressive Supranuclear PalsyBehavioral Variant Frontotemporal Dementia+3 more University Health Network, Toronto 100
Testing effectiveness (Phase 2)Study completedNCT05163886What this trial is testingStudy of Safety, Tolerability, and Biological Activity of LAM-002A in C9ORF72-Associated Amyotrophic Lateral SclerosisWho this might be right forAmyotrophic Lateral SclerosisALS OrphAI Therapeutics 14
Early research (Phase 1)Active Not RecruitingNCT07204977What this trial is testingAcamprosate in C9orf72 Hexanucleotide Repeat Expansion Amyotrophic Lateral Sclerosis (ACALS)Who this might be right forAmyotrophic Lateral SclerosisMotor Neuron Disease National Institute of Neurological Disorders and Stroke (NINDS) 30
Not applicableStudy completedNCT04939818What this trial is testingClinical Feasibility of Speech Phenotyping for Remote Assessment of Neurodegenerative and Psychiatric DisordersWho this might be right forAlzheimer DiseaseMild Cognitive ImpairmentDementia With Lewy Bodies+8 more Novoic Limited 172
Not applicableLooking for participantsNCT06051123What this trial is testingEffects of Probiotics in Amyotrophic Lateral Sclerosis-Frontotemporal Dementia Spectrum Disorder (ALS-FTDSD) PatientsWho this might be right forALSFTD Centre hospitalier de l'Université de Montréal (CHUM) 150
Not applicableLooking for participantsNCT06885918What this trial is testingALS Research CollaborativeWho this might be right forAmyotrophic Lateral SclerosisALS (Amyotrophic Lateral Sclerosis)ALS With Frontotemporal Dementia (ALS/FTD)+2 more ALS Therapy Development Institute 2,000