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Results for “AML With Mutated NPM1”

26 trials

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Showing 20 of 26 results

Testing effectiveness (Phase 2)Not Yet RecruitingNCT06930352
What this trial is testing

Ziftomenib for the Treatment of Patients With NPM1 Mutated or KMT2A Rearranged Acute Myeloid Leukemia Not Eligible for Standard Therapy

Who this might be right for
Acute Myeloid Leukemia
Uma Borate 70
Large-scale testing (Phase 3)Study completedNCT01237808
What this trial is testing

Study of Low-Dose Cytarabine and Etoposide With or Without All-Trans Retinoic Acid in Older Patients Not Eligible for Intensive Chemotherapy With Acute Myeloid Leukemia and NPM1 Mutation

Who this might be right for
Acute Myeloid Leukemia (AML)
University of Ulm 144
Not applicableStudy completedNCT07379528
What this trial is testing

Mesenchymal Stem Cells in NPM1 Mutated Low Risk Acute Myeloid Leukemia: a Study of the Tumor Microenvironment and Its Contribution to the Outcome

Who this might be right for
Acute Myeloid Leukaemia (AML)
Fondazione IRCCS Policlinico San Matteo di Pavia 70
Testing effectiveness (Phase 2)Looking for participantsNCT04065399
What this trial is testing

Revumenib in R/R Leukemias Including Those With an MLL/KMT2A Gene Rearrangement or NPM1 Mutation

Who this might be right for
Acute Myeloid LeukemiaAcute Lymphoblastic LeukemiaMixed Lineage Acute Leukemia+2 more
Syndax Pharmaceuticals 447
Testing effectiveness (Phase 2)Looking for participantsNCT04988555
What this trial is testing

DSP-5336 in Relapsed/Refractory AML/ ALL With or Without MLL Rearrangement or NPM1 Mutation

Who this might be right for
Leukemia, Myeloid, AcuteLeukemia, Lymphocytic, Acute
Sumitomo Pharma America, Inc. 362
Early research (Phase 1)Study completedNCT05326516
What this trial is testing

Revumenib in Combination With Chemotherapy in Participants With R/R Acute Leukemia

Who this might be right for
Relapsed/Refractory LeukemiasAcute Lymphoblastic LeukemiaAcute Lymphocytic Leukemia+3 more
Syndax Pharmaceuticals 30
Early research (Phase 1)Looking for participantsNCT06222580
What this trial is testing

SNDX-5613 and Gilteritinib for the Treatment of Relapsed or Refractory FLT3-Mutated Acute Myeloid Leukemia and Concurrent MLL-Rearrangement or NPM1 Mutation

Who this might be right for
Acute Myeloid Leukemia With FLT3/ITD MutationAcute Myeloid Leukemia With KMT2A RearrangementAcute Myeloid Leukemia With NPM1 Mutation+2 more
Uma Borate 30
Not applicableNot Yet RecruitingNCT07080970
What this trial is testing

Observational Study on APL-like aCute Myeloid Leukemia: disTInct Phenotype and Early VAscular complicaTions

Who this might be right for
Acute Myeloid LeukemiaNPM1 Mutation
Gruppo Italiano Malattie EMatologiche dell'Adulto 220
Early research (Phase 1)Looking for participantsNCT06001788
What this trial is testing

Safety and Tolerability of Ziftomenib Combinations in Patients With Relapsed/Refractory Acute Myeloid Leukemia

Who this might be right for
AMLAML With Mutated NPM1Hematologic Malignancy+9 more
Kura Oncology, Inc. 171
Early research (Phase 1)Looking for participantsNCT06313437
What this trial is testing

Revumenib in Combination With 7+3 + Midostaurin in AML

Who this might be right for
Acute Myeloid LeukemiaAML, AdultAML With Gene Mutations+2 more
Richard Stone, MD 22
Not applicableUnknownNCT04931992
What this trial is testing

Outcome of Patients With CBF and/or NPM1-mutated AML in First Molecular Relapse.

Who this might be right for
Acute Myeloid Leukemia
University Hospital, Angers 100
Large-scale testing (Phase 3)Ended earlyNCT05020665
What this trial is testing

Entospletinib Plus Intensive Induction/Consolidation Chemotherapy in Newly Diagnosed NPM1-mutated AML

Who this might be right for
Nucleophosmin 1-mutated Acute Myeloid Leukemia
Kronos Bio 15
Large-scale testing (Phase 3)Looking for participantsNCT07211958
What this trial is testing

Study of Revumenib in Combination With Intensive Chemotherapy in Newly Diagnosed Acute Myeloid Leukemia (AML) With a NPM1 Mutation

Who this might be right for
Acute Myeloid Leukemias
Syndax Pharmaceuticals 468
Large-scale testing (Phase 3)Looking for participantsNCT06652438
What this trial is testing

Revumenib in Combination With Azacitidine + Venetoclax in Patients NPM1-mutated or KMT2A-rearranged AML

Who this might be right for
Acute Myeloid Leukemia, Adult
Stichting Hemato-Oncologie voor Volwassenen Nederland 415
Testing effectiveness (Phase 2)Looking for participantsNCT06424340
What this trial is testing

MB-dNPM1-TCR.1 in Relapsed/Refractory AML

Who this might be right for
Leukemia, Myeloid, Acute
Miltenyi Biomedicine GmbH 29
Testing effectiveness (Phase 2)WithdrawnNCT01835288
What this trial is testing

Arsenic Trioxide in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia

Who this might be right for
Adult Acute Megakaryoblastic Leukemia (M7)Adult Acute Minimally Differentiated Myeloid Leukemia (M0)Adult Acute Monoblastic Leukemia (M5a)+12 more
Stanford University
Testing effectiveness (Phase 2)Looking for participantsNCT05904106
What this trial is testing

Venetoclax Plus Azacitidine Versus Intensive Chemotherapy for Fit Patients With Newly Diagnosed NPM1 Mutated AML

Who this might be right for
Acute Myeloid Leukemia
Technische Universität Dresden 146
Testing effectiveness (Phase 2)Active Not RecruitingNCT06052813
What this trial is testing

BN104 in the Treatment of Acute Leukemia

Who this might be right for
ALL, AdultAML, AdultAcute Leukaemia+4 more
Institut de Recherches Internationales Servier (I.R.I.S.) 66
Testing effectiveness (Phase 2)UnknownNCT04689815
What this trial is testing

Oral Arsenic Trioxide for NPM1-mutated AML

Who this might be right for
NPMc+ AML
The University of Hong Kong 50
Early research (Phase 1)Looking for participantsNCT05735184
What this trial is testing

Investigate the Safety and Tolerability of Ziftomenib in Combination With Venetoclax/Azacitidine, Venetoclax, 7+3, or 7+3+Quizartinib in Patients With AML

Who this might be right for
Acute Myeloid LeukemiaMixed Lineage Leukemia Gene MutationRefractory AML+7 more
Kura Oncology, Inc. 420
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