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Results for “AML With Mutated NPM1”

31 trials

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Showing 20 of 31 results

Early research (Phase 1)Looking for participantsNCT05735184
What this trial is testing

Investigate the Safety and Tolerability of Ziftomenib in Combination With Venetoclax/Azacitidine, Venetoclax, 7+3, or 7+3+Quizartinib in Patients With AML

Who this might be right for
Acute Myeloid LeukemiaMixed Lineage Leukemia Gene MutationRefractory AML+7 more
Kura Oncology, Inc. 420
Early research (Phase 1)Looking for participantsNCT05886049
What this trial is testing

A Phase 1b Study of Menin Inhibitor SNDX- 5613 in Combination With Daunorubicin and Cytarabine in Newly Diagnosed Patients With Acute Myeloid Leukemia and NPM1 Mutated/FLT3 Wildtype or MLL/KMT2A Rearranged or NUP98 Alterations Disease

Who this might be right for
Acute Myeloid LeukemiaAcute Myeloid Leukemia With KMT2A RearrangementAcute Myeloid Leukemia With NPM1 Mutation+1 more
National Cancer Institute (NCI) 38
Large-scale testing (Phase 3)Study completedNCT01237808
What this trial is testing

Study of Low-Dose Cytarabine and Etoposide With or Without All-Trans Retinoic Acid in Older Patients Not Eligible for Intensive Chemotherapy With Acute Myeloid Leukemia and NPM1 Mutation

Who this might be right for
Acute Myeloid Leukemia (AML)
University of Ulm 144
Testing effectiveness (Phase 2)WithdrawnNCT01835288
What this trial is testing

Arsenic Trioxide in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia

Who this might be right for
Adult Acute Megakaryoblastic Leukemia (M7)Adult Acute Minimally Differentiated Myeloid Leukemia (M0)Adult Acute Monoblastic Leukemia (M5a)+12 more
Stanford University
Large-scale testing (Phase 3)Looking for participantsNCT07211958
What this trial is testing

Study of Revumenib in Combination With Intensive Chemotherapy in Newly Diagnosed Acute Myeloid Leukemia (AML) With a NPM1 Mutation

Who this might be right for
Acute Myeloid Leukemias
Syndax Pharmaceuticals 468
Early research (Phase 1)Not Yet RecruitingNCT07583303
What this trial is testing

BSB-2002 After Cyclophosphamide and Fludarabine for the Treatment of Relapsed or Refractory Acute Myeloid Leukemia Patients With NPM1 Mutation

Who this might be right for
Recurrent Acute Myeloid LeukemiaRefractory Acute Myeloid Leukemia
City of Hope Medical Center 19
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07664839
What this trial is testing

Study on the Efficacy and Safety of VA Regimen Compared to "3+7" Regimen in Newly Diagnosed AML With NPM1 or IDH1/IDH2 Mutations

Who this might be right for
Acute Myeloid LeukemiaNPM1 MutationIDH1 Mutation+1 more
Shen yang 148
Testing effectiveness (Phase 2)Looking for participantsNCT05904106
What this trial is testing

Venetoclax Plus Azacitidine Versus Intensive Chemotherapy for Fit Patients With Newly Diagnosed NPM1 Mutated AML

Who this might be right for
Acute Myeloid Leukemia
Technische Universität Dresden 146
Testing effectiveness (Phase 2)Looking for participantsNCT04988555
What this trial is testing

Enzomenib (DSP-5336) in Patients With Acute Leukemia (Horizen-1)

Who this might be right for
Leukemia, Myeloid, AcuteLeukemia, Lymphocytic, AcuteMultiple Myeloma+1 more
Sumitomo Pharma America, Inc. 606
Testing effectiveness (Phase 2)Looking for participantsNCT04065399
What this trial is testing

Revumenib in R/R Leukemias Including Those With an MLL/KMT2A Gene Rearrangement or NPM1 Mutation

Who this might be right for
Acute Myeloid LeukemiaAcute Lymphoblastic LeukemiaMixed Lineage Acute Leukemia+2 more
Syndax Pharmaceuticals 447
Early research (Phase 1)Looking for participantsNCT06313437
What this trial is testing

Revumenib in Combination With 7+3 + Midostaurin in AML

Who this might be right for
Acute Myeloid LeukemiaAML, AdultAML With Gene Mutations+2 more
Richard Stone, MD 22
Not applicableUnknownNCT04931992
What this trial is testing

Outcome of Patients With CBF and/or NPM1-mutated AML in First Molecular Relapse.

Who this might be right for
Acute Myeloid Leukemia
University Hospital, Angers 100
Large-scale testing (Phase 3)Looking for participantsNCT06652438
What this trial is testing

Revumenib in Combination With Azacitidine + Venetoclax in Patients NPM1-mutated or KMT2A-rearranged AML

Who this might be right for
Acute Myeloid Leukemia, Adult
Stichting Hemato-Oncologie voor Volwassenen Nederland 448
Not applicableStudy completedNCT07379528
What this trial is testing

Mesenchymal Stem Cells in NPM1 Mutated Low Risk Acute Myeloid Leukemia: a Study of the Tumor Microenvironment and Its Contribution to the Outcome

Who this might be right for
Acute Myeloid Leukaemia (AML)
Fondazione IRCCS Policlinico San Matteo di Pavia 70
Testing effectiveness (Phase 2)Looking for participantsNCT07623616
What this trial is testing

Clinical Study of Ziftomenib in Patients With Relapsed or Refractory NPM1-Mutated Acute Myeloid Leukemia

Who this might be right for
Acute Myeloid Leukemia (AML)
Kyowa Kirin Co., Ltd. 6
Large-scale testing (Phase 3)Ended earlyNCT05020665
What this trial is testing

Entospletinib Plus Intensive Induction/Consolidation Chemotherapy in Newly Diagnosed NPM1-mutated AML

Who this might be right for
Nucleophosmin 1-mutated Acute Myeloid Leukemia
Kronos Bio 15
Testing effectiveness (Phase 2)Ended earlyNCT06268574
What this trial is testing

Safety and Efficacy of RVU120 for Treatment of Relapsed/Refractory AML

Who this might be right for
Acute Myeloid Leukemia (AML)High-risk Myelodysplastic Syndrome
Ryvu Therapeutics SA 62
Testing effectiveness (Phase 2)Looking for participantsNCT06930352
What this trial is testing

Ziftomenib for the Treatment of Patients With NPM1 Mutated or KMT2A Rearranged Acute Myeloid Leukemia Not Eligible for Standard Therapy

Who this might be right for
Acute Myeloid Leukemia
Uma Borate 70
Testing effectiveness (Phase 2)Looking for participantsNCT06424340
What this trial is testing

MB-dNPM1-TCR.1 in Relapsed/Refractory AML

Who this might be right for
Leukemia, Myeloid, Acute
Miltenyi Biomedicine GmbH 29
Large-scale testing (Phase 3)Study completedNCT00893399
What this trial is testing

Study of Chemotherapy in Combination With All-trans Retinoic Acid (ATRA) With or Without Gemtuzumab Ozogamicin in Patients With Acute Myeloid Leukemia (AML) and Mutant Nucleophosmin-1 (NPM1) Gene Mutation

Who this might be right for
Acute Myeloid Leukemia
University of Ulm 600
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