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Results for “AML With Mutated NPM1”

31 trials

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Showing 20 of 31 results

Not applicableUnknownNCT04931992
What this trial is testing

Outcome of Patients With CBF and/or NPM1-mutated AML in First Molecular Relapse.

Who this might be right for
Acute Myeloid Leukemia
University Hospital, Angers 100
Early research (Phase 1)Not Yet RecruitingNCT07355335
What this trial is testing

Ziftomenib + Mezigdomide in Adolesc. and Adults w/ R/R AML

Who this might be right for
KMT2A-rearrangedNPM1-mutant Refractory or Relapsed AML
Massachusetts General Hospital 24
Testing effectiveness (Phase 2)Looking for participantsNCT04988555
What this trial is testing

Enzomenib (DSP-5336) in Patients With Acute Leukemia (Horizen-1)

Who this might be right for
Leukemia, Myeloid, AcuteLeukemia, Lymphocytic, AcuteMultiple Myeloma+1 more
Sumitomo Pharma America, Inc. 606
Early research (Phase 1)Looking for participantsNCT05735184
What this trial is testing

Investigate the Safety and Tolerability of Ziftomenib in Combination With Venetoclax/Azacitidine, Venetoclax, 7+3, or 7+3+Quizartinib in Patients With AML

Who this might be right for
Acute Myeloid LeukemiaMixed Lineage Leukemia Gene MutationRefractory AML+7 more
Kura Oncology, Inc. 420
Not applicableLooking for participantsNCT07080970
What this trial is testing

Observational Study on APL-like aCute Myeloid Leukemia: disTInct Phenotype and Early VAscular complicaTions

Who this might be right for
Acute Myeloid LeukemiaNPM1 Mutation
Gruppo Italiano Malattie EMatologiche dell'Adulto 220
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07664839
What this trial is testing

Study on the Efficacy and Safety of VA Regimen Compared to "3+7" Regimen in Newly Diagnosed AML With NPM1 or IDH1/IDH2 Mutations

Who this might be right for
Acute Myeloid LeukemiaNPM1 MutationIDH1 Mutation+1 more
Shen yang 148
Testing effectiveness (Phase 2)Looking for participantsNCT06424340
What this trial is testing

MB-dNPM1-TCR.1 in Relapsed/Refractory AML

Who this might be right for
Leukemia, Myeloid, Acute
Miltenyi Biomedicine GmbH 29
Large-scale testing (Phase 3)Study completedNCT01237808
What this trial is testing

Study of Low-Dose Cytarabine and Etoposide With or Without All-Trans Retinoic Acid in Older Patients Not Eligible for Intensive Chemotherapy With Acute Myeloid Leukemia and NPM1 Mutation

Who this might be right for
Acute Myeloid Leukemia (AML)
University of Ulm 144
Large-scale testing (Phase 3)Looking for participantsNCT07007312
What this trial is testing

Studies to Assess Ziftomenib in Combination With Ven+Aza or 7+3 in Patients With Untreated NPM1-m or KMT2A-r AML

Who this might be right for
Acute Myeloid Leukemia (AML)
Kura Oncology, Inc. 1,300
Early research (Phase 1)Looking for participantsNCT06222580
What this trial is testing

SNDX-5613 and Gilteritinib for the Treatment of Relapsed or Refractory FLT3-Mutated Acute Myeloid Leukemia and Concurrent MLL-Rearrangement or NPM1 Mutation

Who this might be right for
Acute Myeloid Leukemia With FLT3/ITD MutationAcute Myeloid Leukemia With KMT2A RearrangementAcute Myeloid Leukemia With NPM1 Mutation+2 more
Uma Borate 30
Early research (Phase 1)Not Yet RecruitingNCT07583303
What this trial is testing

BSB-2002 After Cyclophosphamide and Fludarabine for the Treatment of Relapsed or Refractory Acute Myeloid Leukemia Patients With NPM1 Mutation

Who this might be right for
Recurrent Acute Myeloid LeukemiaRefractory Acute Myeloid Leukemia
City of Hope Medical Center 19
Early research (Phase 1)Looking for participantsNCT05886049
What this trial is testing

A Phase 1b Study of Menin Inhibitor SNDX- 5613 in Combination With Daunorubicin and Cytarabine in Newly Diagnosed Patients With Acute Myeloid Leukemia and NPM1 Mutated/FLT3 Wildtype or MLL/KMT2A Rearranged or NUP98 Alterations Disease

Who this might be right for
Acute Myeloid LeukemiaAcute Myeloid Leukemia With KMT2A RearrangementAcute Myeloid Leukemia With NPM1 Mutation+1 more
National Cancer Institute (NCI) 38
Early research (Phase 1)Looking for participantsNCT07751991
What this trial is testing

CHM-029 in Participants With NPM1 Mutated, KMT2A or NUP98 Rearranged AML

Who this might be right for
AML (Acute Myeloid Leukemia)
Charm Therapeutics 40
Large-scale testing (Phase 3)Looking for participantsNCT06652438
What this trial is testing

Revumenib in Combination With Azacitidine + Venetoclax in Patients NPM1-mutated or KMT2A-rearranged AML

Who this might be right for
Acute Myeloid Leukemia, Adult
Stichting Hemato-Oncologie voor Volwassenen Nederland 448
Early research (Phase 1)Study completedNCT05326516
What this trial is testing

Revumenib in Combination With Chemotherapy in Participants With R/R Acute Leukemia

Who this might be right for
Relapsed/Refractory LeukemiasAcute Lymphoblastic LeukemiaAcute Lymphocytic Leukemia+3 more
Syndax Pharmaceuticals 30
Early research (Phase 1)WithdrawnNCT07566585
What this trial is testing

Dose Finding Study to Evaluate the Safety of BSB-2002 in Relapsed or Refractory Acute Myeloid Leukemia (AML) Patients With NPM1 Mutation

Who this might be right for
AML - Acute Myeloid LeukemiaAML With Mutated NPM1AML, Adult Recurrent
BlueSphere Bio, Inc
Testing effectiveness (Phase 2)UnknownNCT04689815
What this trial is testing

Oral Arsenic Trioxide for NPM1-mutated AML

Who this might be right for
NPMc+ AML
The University of Hong Kong 50
Testing effectiveness (Phase 2)Active Not RecruitingNCT06052813
What this trial is testing

BN104 in the Treatment of Acute Leukemia

Who this might be right for
ALL, AdultAML, AdultAcute Leukaemia+4 more
Institut de Recherches Internationales Servier (I.R.I.S.) 66
Large-scale testing (Phase 3)Ended earlyNCT05020665
What this trial is testing

Entospletinib Plus Intensive Induction/Consolidation Chemotherapy in Newly Diagnosed NPM1-mutated AML

Who this might be right for
Nucleophosmin 1-mutated Acute Myeloid Leukemia
Kronos Bio 15
Testing effectiveness (Phase 2)Looking for participantsNCT05904106
What this trial is testing

Venetoclax Plus Azacitidine Versus Intensive Chemotherapy for Fit Patients With Newly Diagnosed NPM1 Mutated AML

Who this might be right for
Acute Myeloid Leukemia
Technische Universität Dresden 146
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