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Results for “ATTR-CM”

68 trials

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Showing 20 of 68 results

Large-scale testing (Phase 3)Active Not RecruitingNCT06194825
What this trial is testing

EPIC-ATTR: A Study to Evaluate the Effect of Eplontersen on the Transthyretin Reduction and Long-term Safety in Chinese Subjects With Transthyretin Amyloid Cardiomyopathy

Who this might be right for
Transthyretin Amyloid Cardiomyopathy
AstraZeneca 64
Early research (Phase 1)Study completedNCT04601051
What this trial is testing

Study to Evaluate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of NTLA-2001 in Patients With Hereditary Transthyretin Amyloidosis With Polyneuropathy (ATTRv-PN) and Patients With Transthyretin Amyloidosis-Related Cardiomyopathy (ATTR-CM)

Who this might be right for
Transthyretin-Related (ATTR) Familial Amyloid PolyneuropathyTransthyretin-Related (ATTR) Familial Amyloid CardiomyopathyWild-Type Transthyretin Cardiac Amyloidosis
Intellia Therapeutics 72
Testing effectiveness (Phase 2)Study completedNCT03458130
What this trial is testing

Study of AG10 in Amyloid Cardiomyopathy

Who this might be right for
Familial ATTR-CM (ATTRm-CM, or FAC)Wild-type ATTR-CM (ATTRwt-CM)
Eidos Therapeutics, a BridgeBio company 49
Testing effectiveness (Phase 2)Active Not RecruitingNCT06260709
What this trial is testing

A Research Study to Look at Long-term Treatment With a Medicine Called NNC6019-0001 for People Who Have Heart Failure Due to Transthyretin Amyloidosis

Who this might be right for
Transthyretin Amyloid Cardiomyopathy (ATTR CM)
Novo Nordisk A/S 80
Not applicableActive Not RecruitingNCT06393465
What this trial is testing

Real-World Effectiveness of High-Dose Tafamidis on Neurologic Disease Progression in Mixed-Phenotype Transthyretin Amyloid Cardiomyopathy

Who this might be right for
Transthyretin Amyloidosis Cardiomyopathy (ATTR-CM)
Pfizer 50
Testing effectiveness (Phase 2)Active Not RecruitingNCT07213583
What this trial is testing

Study of Re-Treatment With ALXN2220 in Patients With ATTR-CM

Who this might be right for
Amyloid Transthyretin Cardiomyopathy
Neurimmune AG 35
Not applicableUnknownNCT05210010
What this trial is testing

A Prospective Study to Assess the Utility of CA-4F in a Canadian Cardiology Setting

Who this might be right for
Transthyretin Amyloid Cardiomyopathy ("ATTR-CM")
Ensho Health Intelligent Systems Inc. 8
Post-approval studies (Phase 4)Looking for participantsNCT04935021
What this trial is testing

Clinical Study of ATTR-CM

Who this might be right for
Transthyroxine Amyloidosis Cardiomyopathy
Second Affiliated Hospital, School of Medicine, Zhejiang University 100
Not applicableNot Yet RecruitingNCT06075823
What this trial is testing

Edge-to-edge Mitral Valve Repair in ATTR-CM

Who this might be right for
Mitral RegurgitationATTR-CardiomyopathyEdge-to-Edge Mitral Valve Repair
Medical University of Vienna 100
Large-scale testing (Phase 3)Active Not RecruitingNCT06128629
What this trial is testing

MAGNITUDE: A Phase 3 Study of NTLA-2001 in Participants With Transthyretin Amyloidosis With Cardiomyopathy (ATTR-CM)

Who this might be right for
Transthyretin Amyloidosis (ATTR) With Cardiomyopathy
Intellia Therapeutics 1,200
Large-scale testing (Phase 3)Enrolling By InvitationNCT06679946
What this trial is testing

Evaluate Vutrisiran in Patients With Transthyretin Amyloidosis With Cardiomyopathy

Who this might be right for
Transthyretin Amyloidosis (ATTR) With Cardiomyopathy
Alnylam Pharmaceuticals 700
Not applicableLooking for participantsNCT07235462
What this trial is testing

Learn About the Use of Acoramidis in Patients With a Heart Condition Called Transthyretin Amyloid Cardiomyopathy (ATTR-CM) in a Real-world Setting

Who this might be right for
Transthyretin Amyloid Cardiomyopathy (ATTR-CM)
Bayer 2,000
Large-scale testing (Phase 3)Not Yet RecruitingNCT07116473
What this trial is testing

To Evaluate the Long-term Safety and Tolerability of Acoramidis in Participants With Newly Diagnosed ATTR-CM (ACT-EARLY OLE)

Who this might be right for
Amyloidosis in Transthyretin (TTR)Amyloidosis, FamilialAmyloid Cardiomyopathy+7 more
Eidos Therapeutics, a BridgeBio company 250
Large-scale testing (Phase 3)Active Not RecruitingNCT04153149
What this trial is testing

HELIOS-B: A Study to Evaluate Vutrisiran in Patients With Transthyretin Amyloidosis With Cardiomyopathy

Who this might be right for
Transthyretin Amyloidosis (ATTR) With Cardiomyopathy
Alnylam Pharmaceuticals 655
Not applicableEnded earlyNCT04424914
What this trial is testing

Global Prevalence of ATTR-CM in Participants With HFpEF

Who this might be right for
Transthyretin Amyloid CardiomyopathyHeart Failure With Preserved Ejection Fraction
Pfizer 347
Testing effectiveness (Phase 2)Looking for participantsNCT06539208
What this trial is testing

A Phase I/IIa，Open-label, Single Ascending Dose and Dose-expansion Clinical Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of YOLT-201 in Patients With Transthyretin Amyloidosis Polyneuropathy (ATTR-PN) or Transthyretin Amyloidosis Cardiomyopathy (ATTR-CM)

Who this might be right for
Transthyretin Amyloidosis PolyneuropathyTransthyrexin Amyloidosis Cardiomyopathy
YolTech Therapeutics Co., Ltd 31
Not applicableStudy completedNCT04276220
What this trial is testing

Prevalence of wtATTR-CM After Carpal Tunnel Release Surgery

Who this might be right for
Transthyretin AmyloidosisTransthyretin Cardiac AmyloidosisWild-Type Transthyretin-Related (ATTR)Amyloidosis
Steen Hvitfeldt Poulsen 109
Post-approval studies (Phase 4)Not Yet RecruitingNCT07298044
What this trial is testing

Learn More About the Change in the Blood Levels of Transthyretin When Participants With Transthyretin Amyloidosis With Cardiomyopathy Switch From Tafamidis to Acoramidis

Who this might be right for
Transthyretin Amyloid Cardiomyopathy
Bayer 50
Not applicableStudy completedNCT01604122
What this trial is testing

Burden of Disease Study In Patients With Transthyretin Familial Amyloidosis Polyneuropathy (TTR-FAP) orTransthyretin Cardiomyopathy (TTR-CM) And Caregivers

Who this might be right for
Transthyretin Familial Amyloidosis Polyneuropathy (TTR-FAP)Transthyretin Cardiomyopathy (TTR-CM)Familial Amyloid Cardiomyopathy+1 more
Pfizer 1
Not applicableStudy completedNCT06321523
What this trial is testing

Learn About the Study Medicine Called Tafamidis 61mg in People Diagnosed With Transthyretin Amyloid Cardiomyopathy (ATTR-CM)

Who this might be right for
Transthyretin Amyloid Cardiomyopathy
Pfizer 13
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