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Results for “Abemaciclib”

184 trials

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Showing 20 of 184 results

Post-approval studies (Phase 4)Ended earlyNCT04031885
What this trial is testing

Abemaciclib (LY2835219) in Combination With Fulvestrant Compared to Chemotherapy in Women With HR Positive, HER2 Negative Metastatic Breast Cancer

Who this might be right for
Metastatic Breast Cancer
Eli Lilly and Company 4
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07410559
What this trial is testing

Neoadjuvant Imlunestrant Plus Abemaciclib Treatment Guided by Ki67 Index After 2 Weeks for ER-Positive HER2-Negative Breast Cancer

Who this might be right for
Breast Cancer
Fudan University 189
Testing effectiveness (Phase 2)Looking for participantsNCT04750928
What this trial is testing

Cyclin-Dependent Kinase (CDK)4/6 Inhibitor Abemaciclib for Neurofibromatosis Type I (NF1) Related Atypical Neurofibromas

Who this might be right for
Neurofibromatosis 1
National Cancer Institute (NCI) 55
Not applicableStudy completedNCT05789771
What this trial is testing

Abemaciclib for the Treatment of Luminal Metastatic breAst caNcer in the Real-life Clinical pracTice in Russia.

Who this might be right for
HR+/HER2- Breast CancerMetastatic DiseaseАdvanced Disease
Blokhin's Russian Cancer Research Center 136
Testing effectiveness (Phase 2)Active Not RecruitingNCT03969706
What this trial is testing

Abemaciclib in Patients with Oligodendroglioma

Who this might be right for
Oligodendroglioma, Adult
Stephen Bagley, MD, MSCE 10
Very early researchWithdrawnNCT04088032
What this trial is testing

Neoadjuvant Study of Abemaciclib, Durvalumab, and an Aromatase Inhibitor Early Stage Breast Cancer

Who this might be right for
Breast Cancer FemaleLocally Advanced Breast CancerHormone Receptor Positive Malignant Neoplasm of Breast
Alison Stopeck
Post-approval studies (Phase 4)WithdrawnNCT03988114
What this trial is testing

Abemaciclib (LY2835219) in Participants With HR+, HER2- Advanced Breast Cancer

Who this might be right for
Metastatic Breast Cancer
Eli Lilly and Company
Early research (Phase 1)WithdrawnNCT04585724
What this trial is testing

Stereotactic Radiosurgery With Abemaciclib, Ribociclib, or Palbociclib in Treating Patients With Hormone Receptor Positive Breast Cancer With Brain Metastases

Who this might be right for
Anatomic Stage IV Breast Cancer American Joint Committee on Cancer (AJCC) v8Metastatic Breast CarcinomaMetastatic Malignant Neoplasm in the Brain+1 more
Emory University
Testing effectiveness (Phase 2)Looking for participantsNCT03675893
What this trial is testing

RESOLVE: Abemaciclib + Letrozole +/- Metformin, Zotatifin, or Gedatolisib in Endometrial or Low-Grade Serous Ovarian Cancer

Who this might be right for
Endometrial CancerOvarian Cancer
Dana-Farber Cancer Institute 180
Early research (Phase 1)Study completedNCT05999968
What this trial is testing

Abemaciclib Plus Darolutamide in Prostate Cancer That Has Spread After Initial Treatment

Who this might be right for
Prostatic Neoplasms
Eli Lilly and Company 10
Not applicableLooking for participantsNCT07407439
What this trial is testing

Real-world Studies of CDK4/6 Inhibitors

Who this might be right for
Breast Cancer
Tianjin Medical University Cancer Institute and Hospital 245
Testing effectiveness (Phase 2)Active Not RecruitingNCT04393285
What this trial is testing

Abemaciclib and Letrozole to Treat Endometrial Cancer

Who this might be right for
Endometrial Cancer
Gynecologic Oncology Group 53
Post-approval studies (Phase 4)Not Yet RecruitingNCT07490509
What this trial is testing

Pharmacokinetic Model of Abemaciclib: Correlation With Severe Diarrhea as the Primary Toxicity Endpoint in Patients With Localized Hormone Receptor-positive Breast Cancer

Who this might be right for
AbemaciclibAbemaciclib-related DiarrheaBreast Cancer
Poitiers University Hospital 235
Early research (Phase 1)Study completedNCT04514159
What this trial is testing

ZN-c5 and Abemaciclib in Participants With Breast Cancer

Who this might be right for
Breast Cancer
Zeno Alpha Inc. 14
Post-approval studies (Phase 4)Looking for participantsNCT06169371
What this trial is testing

Abemaciclib Dose Escalation to Maintain Intensity (ADE-MI)

Who this might be right for
Breast Cancer
University of Illinois at Chicago 50
Testing effectiveness (Phase 2)Active Not RecruitingNCT04616183
What this trial is testing

LY3214996 and Cetuximab Alone or in Combination With Abemaciclib for the Treatment of Unresectable or Metastatic Colorectal Cancer

Who this might be right for
Metastatic Colon AdenocarcinomaMetastatic Colorectal CarcinomaMetastatic Rectal Adenocarcinoma+28 more
M.D. Anderson Cancer Center 46
Testing effectiveness (Phase 2)Enrolling By InvitationNCT07441369
What this trial is testing

Abemaciclib Combined With FOLFOX/FOLFIRI Regimen in Patients With Advanced Colorectal Liver Metastases Cancer

Who this might be right for
Liver Metastases From Colorectal Cancer (mCRC)
Fudan University 16
Large-scale testing (Phase 3)Looking for participantsNCT06341621
What this trial is testing

Chemotherapy Omission in ER+/HER2- Breast Cancer With 1-3 Positive Lymph Nodes Receiving Extended Adjuvant Abemaciclib

Who this might be right for
Breast Cancer
Fudan University 1,900
Early research (Phase 1)Looking for participantsNCT06654037
What this trial is testing

Testing the Addition of an Anti-Cancer Drug, Abemaciclib, to the Usual Chemotherapy Treatment (5-Fluorouracil) for Metastatic, Refractory Colorectal Cancer

Who this might be right for
Metastatic Microsatellite Stable Colorectal CarcinomaRefractory Microsatellite Stable Colorectal CarcinomaStage IV Colorectal Cancer AJCC v8
National Cancer Institute (NCI) 39
Testing effectiveness (Phase 2)Active Not RecruitingNCT05548127
What this trial is testing

TACTIVE-U: A Study to Learn About the Study Medicine (Vepdegestrant) When Given With Other Medicines in People With Advanced or Metastatic Breast Cancer (Sub-Study A)

Who this might be right for
Breast Cancer
Pfizer 37
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