Very early researchWithdrawnNCT04220892What this trial is testingPilot Study of Pembrolizumab Combined With Pemetrexed or Abemaciclib for High Grade GliomaWho this might be right forHigh Grade Glioma Jose Carrillo
Testing effectiveness (Phase 2)Study completedNCT04238819What this trial is testingAbemaciclib (LY2835219) in Combination With Other Anti-Cancer Treatments in Children and Young Adult Participants With Solid Tumors, Including NeuroblastomaWho this might be right forRelapsed Solid TumorRefractory Solid Tumor Eli Lilly and Company 47
Large-scale testing (Phase 3)UnknownNCT06152471What this trial is testingEffect of Salovum™ and SPC-Flakes™ on Abemaciclib-induced Gastrointestinal Toxicity in Early Breast CancerWho this might be right forEarly-stage Breast CancerDiarrheaAdverse Drug Event Henrik Lindman 100
Early research (Phase 1)Looking for participantsNCT05372640What this trial is testingTesting the Safety and Efficacy of the Combination of Two Anti-cancer Drugs, ZEN003694 and Abemaciclib, for Adult and Pediatric Patients (12-17 Years) With Metastatic or Unresectable NUT Carcinoma, Breast Cancer and Other Solid TumorsWho this might be right forAnatomic Stage III Breast Cancer AJCC v8Anatomic Stage IV Breast Cancer AJCC v8Metastatic Breast Carcinoma+5 more National Cancer Institute (NCI) 45
Very early researchWithdrawnNCT04088032What this trial is testingNeoadjuvant Study of Abemaciclib, Durvalumab, and an Aromatase Inhibitor Early Stage Breast CancerWho this might be right forBreast Cancer FemaleLocally Advanced Breast CancerHormone Receptor Positive Malignant Neoplasm of Breast Alison Stopeck
Early research (Phase 1)Looking for participantsNCT04633239What this trial is testingTesting the Addition of Abemaciclib to Olaparib for Women With Recurrent Ovarian CancerWho this might be right forRecurrent Ovarian High Grade Serous AdenocarcinomaRecurrent Platinum-Resistant Ovarian Carcinoma National Cancer Institute (NCI) 42
Post-approval studies (Phase 4)Looking for participantsNCT06169371What this trial is testingAbemaciclib Dose Escalation to Maintain Intensity (ADE-MI)Who this might be right forBreast Cancer University of Illinois at Chicago 50
Post-approval studies (Phase 4)Ended earlyNCT04031885What this trial is testingAbemaciclib (LY2835219) in Combination With Fulvestrant Compared to Chemotherapy in Women With HR Positive, HER2 Negative Metastatic Breast CancerWho this might be right forMetastatic Breast Cancer Eli Lilly and Company 4
Large-scale testing (Phase 3)Active Not RecruitingNCT04964934What this trial is testingPhase III Study to Assess AZD9833+ CDK4/6 Inhibitor in HR+/HER2-MBC With Detectable ESR1m Before Progression (SERENA-6)Who this might be right forER-Positive HER2-Negative Breast Cancer AstraZeneca 315
Testing effectiveness (Phase 2)Active Not RecruitingNCT02747004What this trial is testingAbemaciclib (LY2835219) Plus Tamoxifen or Abemaciclib Alone in Women With Metastatic Breast CancerWho this might be right forMetastatic Breast Cancer Eli Lilly and Company 234
Early research (Phase 1)Study completedNCT02677844What this trial is testingAbemaciclib in Healthy ParticipantsWho this might be right forHealthy Eli Lilly and Company 35
Testing effectiveness (Phase 2)Ended earlyNCT03938337What this trial is testingAbemaciclib and Pembrolizumab in Metastatic or Recurrent Head and Neck CancerWho this might be right forHead and Neck Cancer University of Alabama at Birmingham 1
Testing effectiveness (Phase 2)Study completedNCT02441946What this trial is testingA Neoadjuvant Study of Abemaciclib (LY2835219) in Postmenopausal Women With Hormone Receptor Positive, HER2 Negative Breast CancerWho this might be right forBreast CancerHormone Receptor Positive TumorEarly-Stage Breast Carcinoma Eli Lilly and Company 224
Early research (Phase 1)Looking for participantsNCT06654037What this trial is testingTesting the Addition of an Anti-Cancer Drug, Abemaciclib, to the Usual Chemotherapy Treatment (5-Fluorouracil) for Metastatic, Refractory Colorectal CancerWho this might be right forMetastatic Microsatellite Stable Colorectal CarcinomaRefractory Microsatellite Stable Colorectal CarcinomaStage IV Colorectal Cancer AJCC v8 National Cancer Institute (NCI) 39
Post-approval studies (Phase 4)Study completedNCT04707196What this trial is testingAbemaciclib in Indian Women With Advanced Breast CancerWho this might be right forBreast NeoplasmsNeoplasm Metastasis Eli Lilly and Company 200
Testing effectiveness (Phase 2)Active Not RecruitingNCT05548127What this trial is testingTACTIVE-U: A Study to Learn About the Study Medicine (Vepdegestrant) When Given With Other Medicines in People With Advanced or Metastatic Breast Cancer (Sub-Study A)Who this might be right forBreast Cancer Pfizer 37
Not applicableLooking for participantsNCT06621459What this trial is testingRetrospective Observational Study of the Safety and Toxicity Management of Abemaciclib in Combination with Adjuvant Hormone Therapy in Patients with RH+ ,HER2-nonoveramplified Breast Cancer, Real-life Data (MONARCHE29)Who this might be right forBrest CancerAbemaciclibAdjuvant Therapy+2 more University Hospital, Brest 30
Testing effectiveness (Phase 2)WithdrawnNCT04351230What this trial is testingT-DM1 With or Without Abemaciclib for the Treatment of HER2-Positive Metastatic Breast CancerWho this might be right forAnatomic Stage IV Breast Cancer AJCC v8HER2 Positive Breast CarcinomaMetastatic Breast Carcinoma+1 more Academic and Community Cancer Research United
Not applicableLooking for participantsNCT07407439What this trial is testingReal-world Studies of CDK4/6 InhibitorsWho this might be right forBreast Cancer Tianjin Medical University Cancer Institute and Hospital 245
Testing effectiveness (Phase 2)Looking for participantsNCT05766410What this trial is testingStudy Comparing the Immune Modulation Effect of Ribociclib, Palbociclib, and Abemaciclib in ER+/HER2- EBCWho this might be right forBreast CancerHormone Receptor-positive Breast CancerHormone Therapy National Taiwan University Hospital 60