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Results for “Acute Myeloid Leukemia, With NPM1 Mutations”

26 trials

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Showing 20 of 26 results

Testing effectiveness (Phase 2)Ended earlyNCT06268574
What this trial is testing

Safety and Efficacy of RVU120 for Treatment of Relapsed/Refractory AML

Who this might be right for
Acute Myeloid Leukemia (AML)High-risk Myelodysplastic Syndrome
Ryvu Therapeutics SA 62
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07664839
What this trial is testing

Study on the Efficacy and Safety of VA Regimen Compared to "3+7" Regimen in Newly Diagnosed AML With NPM1 or IDH1/IDH2 Mutations

Who this might be right for
Acute Myeloid LeukemiaNPM1 MutationIDH1 Mutation+1 more
Shen yang 148
Early research (Phase 1)Study completedNCT05326516
What this trial is testing

Revumenib in Combination With Chemotherapy in Participants With R/R Acute Leukemia

Who this might be right for
Relapsed/Refractory LeukemiasAcute Lymphoblastic LeukemiaAcute Lymphocytic Leukemia+3 more
Syndax Pharmaceuticals 30
Testing effectiveness (Phase 2)Active Not RecruitingNCT06052813
What this trial is testing

BN104 in the Treatment of Acute Leukemia

Who this might be right for
ALL, AdultAML, AdultAcute Leukaemia+4 more
Institut de Recherches Internationales Servier (I.R.I.S.) 66
Early research (Phase 1)Looking for participantsNCT06222580
What this trial is testing

SNDX-5613 and Gilteritinib for the Treatment of Relapsed or Refractory FLT3-Mutated Acute Myeloid Leukemia and Concurrent MLL-Rearrangement or NPM1 Mutation

Who this might be right for
Acute Myeloid Leukemia With FLT3/ITD MutationAcute Myeloid Leukemia With KMT2A RearrangementAcute Myeloid Leukemia With NPM1 Mutation+2 more
Uma Borate 30
Not applicableStudy completedNCT07379528
What this trial is testing

Mesenchymal Stem Cells in NPM1 Mutated Low Risk Acute Myeloid Leukemia: a Study of the Tumor Microenvironment and Its Contribution to the Outcome

Who this might be right for
Acute Myeloid Leukaemia (AML)
Fondazione IRCCS Policlinico San Matteo di Pavia 70
Not applicableAvailableNCT05738538
What this trial is testing

Expanded Access to Ziftomenib

Who this might be right for
Acute Lymphoblastic Leukemia, With KMT2A RearrangementsAcute Myeloid Leukemia, With NPM1 MutationsAcute Myeloid Leukemia, With KMT2A Rearrangements
Kura Oncology, Inc.
Large-scale testing (Phase 3)Looking for participantsNCT07211958
What this trial is testing

Study of Revumenib in Combination With Intensive Chemotherapy in Newly Diagnosed Acute Myeloid Leukemia (AML) With a NPM1 Mutation

Who this might be right for
Acute Myeloid Leukemias
Syndax Pharmaceuticals 468
Early research (Phase 1)Looking for participantsNCT06001788
What this trial is testing

Safety and Tolerability of Ziftomenib Combinations in Patients With Relapsed/Refractory Acute Myeloid Leukemia

Who this might be right for
AMLAML With Mutated NPM1Hematologic Malignancy+9 more
Kura Oncology, Inc. 171
Large-scale testing (Phase 3)Study completedNCT00893399
What this trial is testing

Study of Chemotherapy in Combination With All-trans Retinoic Acid (ATRA) With or Without Gemtuzumab Ozogamicin in Patients With Acute Myeloid Leukemia (AML) and Mutant Nucleophosmin-1 (NPM1) Gene Mutation

Who this might be right for
Acute Myeloid Leukemia
University of Ulm 600
Early research (Phase 1)Looking for participantsNCT06313437
What this trial is testing

Revumenib in Combination With 7+3 + Midostaurin in AML

Who this might be right for
Acute Myeloid LeukemiaAML, AdultAML With Gene Mutations+2 more
Richard Stone, MD 22
Large-scale testing (Phase 3)Study completedNCT01237808
What this trial is testing

Study of Low-Dose Cytarabine and Etoposide With or Without All-Trans Retinoic Acid in Older Patients Not Eligible for Intensive Chemotherapy With Acute Myeloid Leukemia and NPM1 Mutation

Who this might be right for
Acute Myeloid Leukemia (AML)
University of Ulm 144
Early research (Phase 1)Looking for participantsNCT07751991
What this trial is testing

CHM-029 in Participants With NPM1 Mutated, KMT2A or NUP98 Rearranged AML

Who this might be right for
AML (Acute Myeloid Leukemia)
Charm Therapeutics 40
Early research (Phase 1)Ended earlyNCT05153330
What this trial is testing

Study of BMF-219, a Covalent Menin Inhibitor, in Adult Patients With AML, ALL (With KMT2A/ MLL1r, NPM1 Mutations), DLBCL, MM, and CLL/SLL

Who this might be right for
Acute Myeloid LeukemiaAcute Lymphoblastic LeukemiaAcute Mixed-Phenotype Leukemia+12 more
Biomea Fusion Inc. 55
Early research (Phase 1)Looking for participantsNCT05735184
What this trial is testing

Investigate the Safety and Tolerability of Ziftomenib in Combination With Venetoclax/Azacitidine, Venetoclax, 7+3, or 7+3+Quizartinib in Patients With AML

Who this might be right for
Acute Myeloid LeukemiaMixed Lineage Leukemia Gene MutationRefractory AML+7 more
Kura Oncology, Inc. 420
Early research (Phase 1)Looking for participantsNCT05886049
What this trial is testing

A Phase 1b Study of Menin Inhibitor SNDX- 5613 in Combination With Daunorubicin and Cytarabine in Newly Diagnosed Patients With Acute Myeloid Leukemia and NPM1 Mutated/FLT3 Wildtype or MLL/KMT2A Rearranged or NUP98 Alterations Disease

Who this might be right for
Acute Myeloid LeukemiaAcute Myeloid Leukemia With KMT2A RearrangementAcute Myeloid Leukemia With NPM1 Mutation+1 more
National Cancer Institute (NCI) 38
Testing effectiveness (Phase 2)Looking for participantsNCT07623616
What this trial is testing

Clinical Study of Ziftomenib in Patients With Relapsed or Refractory NPM1-Mutated Acute Myeloid Leukemia

Who this might be right for
Acute Myeloid Leukemia (AML)
Kyowa Kirin Co., Ltd. 6
Testing effectiveness (Phase 2)Looking for participantsNCT04988555
What this trial is testing

Enzomenib (DSP-5336) in Patients With Acute Leukemia (Horizen-1)

Who this might be right for
Leukemia, Myeloid, AcuteLeukemia, Lymphocytic, AcuteMultiple Myeloma+1 more
Sumitomo Pharma America, Inc. 606
Testing effectiveness (Phase 2)UnknownNCT04689815
What this trial is testing

Oral Arsenic Trioxide for NPM1-mutated AML

Who this might be right for
NPMc+ AML
The University of Hong Kong 50
Not applicableLooking for participantsNCT07080970
What this trial is testing

Observational Study on APL-like aCute Myeloid Leukemia: disTInct Phenotype and Early VAscular complicaTions

Who this might be right for
Acute Myeloid LeukemiaNPM1 Mutation
Gruppo Italiano Malattie EMatologiche dell'Adulto 220
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