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Results for “Advanced Unresectable or Metastatic Solid Malignancy”

253 trials

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Showing 20 of 253 results

Testing effectiveness (Phase 2)Study completedNCT04632992
What this trial is testing

A Study Evaluating Targeted Therapies in Participants Who Have Advanced Solid Tumors With Genomic Alterations or Protein Expression Patterns Predictive of Response

Who this might be right for
Advanced Unresectable or Metastatic Solid Malignancy
Genentech, Inc. 252
Testing effectiveness (Phase 2)Looking for participantsNCT05086692
What this trial is testing

A Beta-only IL-2 ImmunoTherapY Study

Who this might be right for
Advanced Solid TumorUnresectable Solid TumorClear Cell Renal Cell Carcinoma+34 more
Medicenna Therapeutics, Inc. 115
Early research (Phase 1)Not Yet RecruitingNCT07836036
What this trial is testing

Evaluation of RAS Inhibitor Treatment in Participants With Advanced or Metastatic Solid Tumors Harboring RAS Mutations

Who this might be right for
Solid TumorRAS Mutation
Jiangsu Aosaikang Pharmaceutical Co., Ltd. 200
Early research (Phase 1)Looking for participantsNCT07189195
What this trial is testing

TR-002 for the Treatment of Advanced Unresectable Metastatic Solid Tumors Unresectable or Metastatic, Refractory Pancreatic Adenocarcinoma

Who this might be right for
Advanced Malignant Solid NeoplasmMetastatic Malignant Solid NeoplasmMetastatic Pancreatic Adenocarcinoma+5 more
University of California, Davis 52
Early research (Phase 1)Ended earlyNCT00086970
What this trial is testing

Ifosfamide With or Without O(6)-Benzylguanine in Treating Patients With Unresectable, Metastatic Solid Tumors

Who this might be right for
Unspecified Adult Solid Tumor, Protocol Specific
National Cancer Institute (NCI) 32
Testing effectiveness (Phase 2)Active Not RecruitingNCT04940299
What this trial is testing

Tocilizumab, Ipilimumab, and Nivolumab for the Treatment of Advanced Melanoma, Non-Small Cell Lung Cancer, or Urothelial Carcinoma

Who this might be right for
Clinical Stage III Cutaneous Melanoma AJCC v8Clinical Stage IV Cutaneous Melanoma AJCC v8Locally Advanced Bladder Carcinoma+39 more
M.D. Anderson Cancer Center 35
Testing effectiveness (Phase 2)Active Not RecruitingNCT04639219
What this trial is testing

T-DXd for the Treatment of Solid Tumors Harboring HER2 Activating Mutations

Who this might be right for
Advanced Solid Tumors With HER2 Mutation,eg:Colorectal,Urothelial,Gastric, Hepatobiliary,Endometrial,Melanoma,Ovarian,Cervical,Salivary Gland,Pancreatic,Breast
AstraZeneca 102
Early research (Phase 1)Study completedNCT05396833
What this trial is testing

Study of Tuvusertib (M1774) in Combination With DNA Damage Response Inhibitor or Immune Checkpoint Inhibitor (DDRiver Solid Tumors 320)

Who this might be right for
Metastatic or Locally Advanced Unresectable Solid Tumors
EMD Serono Research & Development Institute, Inc. 120
Testing effectiveness (Phase 2)UnknownNCT05842785
What this trial is testing

TSN222 in Subjects With Advanced Solid Tumors or Lymphomas

Who this might be right for
Has a Pathologically Documented Unresectable Locally Advanced or Metastatic Solid Tumor or Lymphoma
Tyligand Bioscience (Shanghai) Limited 162
Early research (Phase 1)Study completedNCT00255658
What this trial is testing

Sorafenib and Temsirolimus in Treating Patients With Unresectable or Metastatic Solid Tumors

Who this might be right for
Unspecified Adult Solid Tumor, Protocol Specific
National Cancer Institute (NCI) 40
Testing effectiveness (Phase 2)Study completedNCT02401815
What this trial is testing

CGT9486 (Formerly Known as PLX9486) as a Single Agent and in Combination With PLX3397 (Pexidartinib) or Sunitinib in Participants With Advanced Solid Tumors

Who this might be right for
Gastrointestinal Stromal Tumors
Cogent Biosciences, Inc. 51
Early research (Phase 1)Temporarily pausedNCT07395258
What this trial is testing

Test Different Doses of BI 3923948 Alone and in Combination With an Anti-PD-1 Antibody in People With Different Types of Advanced Cancer (Solid Tumors)

Who this might be right for
Solid Tumors
Boehringer Ingelheim 60
Testing effectiveness (Phase 2)Ended earlyNCT03149549
What this trial is testing

PROCLAIM-CX-2009: A Trial to Find Safe and Active Doses of an Investigational Drug CX-2009 for Patients With Selected Solid Tumors

Who this might be right for
Solid Tumor, AdultBreast CancerNon Small Cell Lung Cancer+2 more
CytomX Therapeutics 99
Testing effectiveness (Phase 2)Ended earlyNCT04003623
What this trial is testing

Efficacy and Safety of Pemigatinib in Participants With Solid Tumors With FGFR Mutations or Translocations (FIGHT-208)

Who this might be right for
Advanced or Metastatic Solid TumorsFGFR MutationsFGFR Translocations
Incyte Corporation 1
Early research (Phase 1)UnknownNCT04987112
What this trial is testing

Intratumoral CAN1012(Selective TLR7 Agonist) in Subjects With Solid Tumors

Who this might be right for
Solid TumorCancer Metastatic
CanWell Pharma Inc. 36
Early research (Phase 1)Ended earlyNCT02419495
What this trial is testing

Phase IB Study to Evaluate the Safety of Selinexor (KPT-330) in Combination With Multiple Standard Chemotherapy or Immunotherapy Agents in Patients With Advanced Malignancies

Who this might be right for
Advanced Malignant Solid NeoplasmClinical Stage III Cutaneous Melanoma AJCC v8Clinical Stage IV Cutaneous Melanoma AJCC v8+26 more
M.D. Anderson Cancer Center 221
Testing effectiveness (Phase 2)Study completedNCT03852251
What this trial is testing

AK104, a PD-1/CTLA-4 Bispecific Antibody, for Advanced Solid Tumors or With mXELOX/XELOX as First-line Therapy for Advanced Gastric or GEJ Adenocarcinoma

Who this might be right for
Gastric AdenocarcinomaAdvanced Solid TumorsGastroesophageal Junction Adenocarcinoma
Akeso 338
Testing effectiveness (Phase 2)Looking for participantsNCT07158918
What this trial is testing

ABL103 in Combination With Pembrolizumab, With or Without Taxane in Advanced or Metastatic Solid Tumors

Who this might be right for
Solid Tumors
ABL Bio, Inc. 65
Testing effectiveness (Phase 2)Looking for participantsNCT05267626
What this trial is testing

Study of AU-007, A Monoclonal Antibody That Binds to IL-2 and Inhibits IL-2Rα Binding, in Patients With Unresectable Locally Advanced or Metastatic Cancer

Who this might be right for
Advanced Solid TumorMetastatic CancerCutaneous Melanoma+1 more
Aulos Bioscience, Inc. 159
Testing effectiveness (Phase 2)Ended earlyNCT05572684
What this trial is testing

A Safety, Tolerability and Efficacy Study of NC410 Plus Pembrolizumab in Participants With Advanced Unresectable or Metastatic Solid Tumors

Who this might be right for
Advanced or Metastatic Solid TumorsMicrosatellite Instability LowMicrosatellite Instability High+9 more
NextCure, Inc. 97
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