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Results for “Advanced and Selected Solid Tumors”

223 trials

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Showing 20 of 223 results

Testing effectiveness (Phase 2)WithdrawnNCT05234606
What this trial is testing

A Safety and Preliminary Efficacy Study of SBT6290 Alone and in Combination With PD-(L)1 Inhibitors in Select Advanced Solid Tumors

Who this might be right for
Urothelial CarcinomaTriple Negative Breast CancerNon-small Cell Lung Cancer+2 more
Silverback Therapeutics
Early research (Phase 1)Study completedNCT03811652
What this trial is testing

A Multiple Ascending Dose Study of MEDI7247 in Advanced or Metastatic Solid Tumors

Who this might be right for
Non Small Cell Lung Cancer Squamous (NSCLC-Sq)Head and Neck Squamous Cell Carcinoma (HNSCC)Small Cell Lung Cancer (SCLC)+3 more
MedImmune LLC 8
Testing effectiveness (Phase 2)Study completedNCT03797326
What this trial is testing

Efficacy and Safety of Pembrolizumab (MK-3475) Plus Lenvatinib (E7080/MK-7902) in Previously Treated Participants With Select Solid Tumors (MK-7902-005/E7080-G000-224/LEAP-005)

Who this might be right for
Advanced Solid TumorsTriple Negative Breast CancerOvarian Cancer+5 more
Merck Sharp & Dohme LLC 611
Testing effectiveness (Phase 2)Looking for participantsNCT06819735
What this trial is testing

Study of DT-7012 as a Single Agent and in Combination With an Immune Checkpoint Inhibitor in Participants With Advanced Solid Tumors

Who this might be right for
Advanced Solid Tumors
Domain Therapeutics Australia Pty Ltd 125
Testing effectiveness (Phase 2)Active Not RecruitingNCT03213652
What this trial is testing

Ensartinib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With ALK or ROS1 Genomic Alterations (A Pediatric MATCH Treatment Trial)

Who this might be right for
Advanced Malignant Solid NeoplasmMalignant Solid NeoplasmRecurrent Ependymoma+30 more
National Cancer Institute (NCI) 13
Early research (Phase 1)Study completedNCT01449058
What this trial is testing

A Phase Ib Study of MEK162 Plus BYL719 in Adult Patients With Selected Advanced Solid Tumors

Who this might be right for
Advanced and Selected Solid TumorsAMLHigh Risk and Very High Risk MDS
Array BioPharma 139
Early research (Phase 1)Looking for participantsNCT05238922
What this trial is testing

Study of INCB123667 in Subjects With Advanced Solid Tumors

Who this might be right for
Solid Tumors
Incyte Corporation 604
Testing effectiveness (Phase 2)Ended earlyNCT01562899
What this trial is testing

MEK162 and AMG 479 in Patients With Selected Solid Tumors

Who this might be right for
Metastatic Pancreatic AdenocarcinomaBRAF Mutated Melanoma
Pfizer 77
Testing effectiveness (Phase 2)WithdrawnNCT04976660
What this trial is testing

TT-4 As a Single Agent in Subjects with Advanced Selected Solid Tumors

Who this might be right for
Colorectal CancerGastric CancerHepatocellular Carcinoma+1 more
Tarus Therapeutics, Inc.
Early research (Phase 1)Study completedNCT03517488
What this trial is testing

XmAb®20717 in Subjects With Selected Advanced Solid Tumors

Who this might be right for
MelanomaBreast CarcinomaHepatocellular Carcinoma+25 more
Xencor, Inc. 150
Early research (Phase 1)Looking for participantsNCT06427941
What this trial is testing

BGB-B2033, Alone or in Combination With Tislelizumab With or Without Bevacizumab, in Participants With Advanced or Metastatic Solid Tumors

Who this might be right for
Metastatic Hepatocellular CarcinomaLocal Advanced Hepatocellular CarcinomaAlpha-fetoprotein (AFP)-Producing Gastric Cancer+2 more
BeOne Medicines 140
Testing effectiveness (Phase 2)UnknownNCT05453825
What this trial is testing

Navicixizumab Monotherapy or in Combination in Patients With Select Advanced Solid Tumors

Who this might be right for
Colorectal CancerTriple Negative Breast CancerGastric Cancer+1 more
OncXerna Theraputics, Inc. 180
Early research (Phase 1)WithdrawnNCT05010096
What this trial is testing

BAY1895344 and Copanlisib for the Treatment of Molecularly Selected Patients With Advanced Solid Tumors

Who this might be right for
Locally Advanced Malignant Solid NeoplasmMetastatic Malignant Neoplasm in the BoneMetastatic Malignant Solid Neoplasm+1 more
M.D. Anderson Cancer Center
Early research (Phase 1)Active Not RecruitingNCT03983954
What this trial is testing

Naptumomab Estafenatox in Combination With Durvalumab in Subjects With Selected Advanced or Metastatic Solid Tumor, Including a Cohort Expansion in Esophageal Cancer.

Who this might be right for
ER+ Breast CancerOvarian CancerCervical Squamous Cell Carcinoma+17 more
NeoTX Therapeutics Ltd. 120
Early research (Phase 1)Study completedNCT01155453
What this trial is testing

Investigate Safety, Pharmacokinetics (PK) and Pharmacodynamics (PD) of BKM120 Plus GSK1120212 in Selected Advanced Solid Tumor Patients

Who this might be right for
Advanced and Selected Solid Tumors
Novartis Pharmaceuticals 113
Testing effectiveness (Phase 2)Looking for participantsNCT04643418
What this trial is testing

Phase 1/2a Study of MPB-1734 in Patients With Advanced Solid Tumors

Who this might be right for
Solid Tumor, Unspecified, Adult
MegaPro Biomedical Co. Ltd. 81
Early research (Phase 1)Active Not RecruitingNCT05544929
What this trial is testing

Safety and Efficacy of KFA115 Alone and in Combo With Pembrolizumab in Patients With Select Advanced Cancers

Who this might be right for
Carcinoma, Non-Small-Cell LungCutaneous MelanomaCarcinoma, Renal Cell+9 more
Novartis Pharmaceuticals 126
Early research (Phase 1)Active Not RecruitingNCT05827614
What this trial is testing

Study of the CHK1 Inhibitor BBI-355, an ecDNA-directed Therapy (ecDTx), and the RNR Inhibitor BBI-825, in Subjects With Tumors With Oncogene Amplifications

Who this might be right for
Triple Negative Breast Cancer (TNBC)High Grade Serous Ovarian CarcinomaHigh Grade Endometrial Carcinoma+9 more
Boundless Bio 85
Early research (Phase 1)Active Not RecruitingNCT05537740
What this trial is testing

A First-in-human Study to Learn How Safe the Study Drug BAY3375968, an Anti-CCR8 Antibody, is, When Given Alone or in Combination With Pembrolizumab, How it Affects the Body, How it Moves Into, Through, and Out of the Body, and to Find the Best Dose in Participants With Advanced Solid Tumors

Who this might be right for
Advanced Solid Tumors
Bayer 129
Early research (Phase 1)UnknownNCT05498597
What this trial is testing

AMT-151 in Patients With Selected Advanced Solid Tumours

Who this might be right for
Advanced Solid TumorAdvanced CancerAdvanced Carcinoma+16 more
Multitude Therapeutics Inc. 30
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