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Results for “Advanced or Metastatic KRAS-mutant Tumor”

26 trials

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Showing 20 of 26 results

Testing effectiveness (Phase 2)Looking for participantsNCT07148128
What this trial is testing

Phase 1/2a Study to Assess the Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of WEF-001 as Monotherapy in Advanced KRAS-Mutant Solid Tumours.

Who this might be right for
Advanced or Metastatic KRAS-mutant Tumor in Pancreatic AdenocarcinomaAdvanced or Metastatic KRAS-mutant Tumor in Colorectal CancerAdvanced or Metastatic KRAS-mutant Tumor in Non Small Cell Lung Cancer+2 more
Auricula Biosciences Inc. 110
Large-scale testing (Phase 3)Looking for participantsNCT06119581
What this trial is testing

First-Line Olomorasib (LY3537982) and Pembrolizumab With or Without Chemotherapy in Patients With Advanced KRAS G12C-Mutant Non-small Cell Lung Cancer

Who this might be right for
Carcinoma, Non-Small-Cell LungNeoplasm Metastasis
Eli Lilly and Company 1,264
Early research (Phase 1)Ended earlyNCT06194877
What this trial is testing

Investigate BGB-3245 (Brimarafenib) With Panitumumab in Participants With Advanced or Metastatic RAS Mutant Colorectal and Pancreatic Ductal Cancers

Who this might be right for
Colorectal CancerPancreatic Ductal CancerAdvanced or Metastatic RAS Mutant Colorectal and Pancreatic Ductal Cancers
MapKure, LLC 13
Testing effectiveness (Phase 2)WithdrawnNCT05180422
What this trial is testing

A Phase I/II Study of AMG 510 in Combination With MVASI in Patients With Advanced, Unresectable or Metastatic KRAS G12C Mutant NSCLC With Asymptomatic Brain Metastasis

Who this might be right for
Non Small Cell Lung Cancer
Criterium, Inc.
Large-scale testing (Phase 3)Looking for participantsNCT07190248
What this trial is testing

A Clinical Study of Calderasib (MK-1084) and Other Treatments for Participants With Non-Small Cell Lung Cancer (MK-1084-007/KANDLELIT-007)

Who this might be right for
Non-small Cell Lung Cancer
Merck Sharp & Dohme LLC 675
Large-scale testing (Phase 3)Active Not RecruitingNCT05132075
What this trial is testing

Study of JDQ443 in Comparison With Docetaxel in Participants With Locally Advanced or Metastatic KRAS G12C Mutant Non-small Cell Lung Cancer

Who this might be right for
Non-Small Cell Lung Cancer
Novartis Pharmaceuticals 95
Early research (Phase 1)Study completedNCT01986166
What this trial is testing

MEHD7945A and Cobimetinib in Patients With Locally Advanced or Metastatic Cancers With Mutant KRAS

Who this might be right for
Neoplasms
Genentech, Inc. 23
Testing effectiveness (Phase 2)Looking for participantsNCT05638295
What this trial is testing

Testing the Use of AMG 510 (Sotorasib) and Panitumumab as a Targeted Treatment for KRAS G12C Mutant Solid Tumor Cancers (A ComboMATCH Treatment Trial)

Who this might be right for
Advanced Malignant Solid NeoplasmMetastatic Malignant Solid Neoplasm
National Cancer Institute (NCI) 105
Early research (Phase 1)Ended earlyNCT03948763
What this trial is testing

MRNA-5671/V941 as Monotherapy and in Combination With Pembrolizumab (V941-001)

Who this might be right for
NeoplasmsCarcinoma, Non-Small-Cell LungPancreatic Neoplasms+1 more
Merck Sharp & Dohme LLC 70
Testing effectiveness (Phase 2)Study completedNCT01362296
What this trial is testing

An Open-label Study of GSK1120212 Compared With Docetaxel in Stage IV KRAS-mutant Non-small Cell Lung Cancer

Who this might be right for
Lung Cancer, Non-Small Cell
GlaxoSmithKline 134
Testing effectiveness (Phase 2)Study completedNCT06208124
What this trial is testing

IMM-6-415 in RAS/RAF Mutant Solid Tumors

Who this might be right for
Advanced Solid Tumor (Phase 1)Pancreas AdenocarcinomaNon-small Cell Lung Cancer+1 more
Immuneering Corporation 30
Large-scale testing (Phase 3)Looking for participantsNCT06345729
What this trial is testing

Calderasib (MK-1084) Plus Pembrolizumab (MK-3475) in Participants With KRAS G12C Mutant Non-small Cell Lung Cancer (NSCLC) With Programmed Cell Death Ligand 1 (PD-L1) Tumor Proportion Score (TPS) ≥50% (MK-1084-004/KANDLELIT-004)

Who this might be right for
Non-small Cell Lung Cancer
Merck Sharp & Dohme LLC 600
Large-scale testing (Phase 3)Not Yet RecruitingNCT07232875
What this trial is testing

HRS 4642 Injection Combined With AG Versus Placebo Combined With AG Therapy in First-Line Advanced or Metastatic Pancreatic Cancer

Who this might be right for
KRAS G12D-Mutant Advanced or Metastatic Pancreatic Cancer in the First-line Setting
Jiangsu HengRui Medicine Co., Ltd. 588
Early research (Phase 1)Ended earlyNCT02703571
What this trial is testing

Study of Safety and Efficacy of Ribociclib and Trametinib in Patients With Metastatic or Advanced Solid Tumors

Who this might be right for
Solid Tumors for Phase IbPancreatic Cancer for Phase IIColorectal Cancer for Phase II
Novartis Pharmaceuticals 95
Testing effectiveness (Phase 2)Not Yet RecruitingNCT06435455
What this trial is testing

GH21 Combined With D-1553 in KRAS G12C Mutant Advanced Solid Tumors

Who this might be right for
Locally Advanced or Metastatic Solid Tumors Harboring KRAS G12C Mutation
Suzhou Genhouse Bio Co., Ltd. 126
Early research (Phase 1)Ended earlyNCT02974725
What this trial is testing

A Phase Ib Study of LXH254-centric Combinations in NSCLC or Melanoma

Who this might be right for
Non-Small Cell Lung CancerMelanoma
Novartis Pharmaceuticals 241
Testing effectiveness (Phase 2)Ended earlyNCT05983367
What this trial is testing

Investigate Ompenaclid Combined With FOLFIRI Plus Bevacizumab in Advanced/Metastatic Colorectal Cancer

Who this might be right for
Colorectal CancerMetastatic Colon Cancer
Inspirna, Inc. 76
Testing effectiveness (Phase 2)Active Not RecruitingNCT06166836
What this trial is testing

Evaluate the Safety and Efficacy of D-1553 Combined With IN10018 in KRAS G12C Mutant Solid Tumors

Who this might be right for
Solid Tumor
InxMed (Shanghai) Co., Ltd. 140
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07294261
What this trial is testing

Garsorasib In KRAS G12C Mutant Locally Advanced and Metastatic NSCLC

Who this might be right for
Local Advanced or Metastatic NSCLC
Sun Yat-sen University 69
Early research (Phase 1)Looking for participantsNCT07458347
What this trial is testing

Dose-escalation Trial of KST-6051 in Participants With Advanced Solid Tumors With Kirsten Rat Sarcoma Viral Oncogene Homolog (KRAS) Mutation

Who this might be right for
KRAS-mutant Non-small Cell Lung Cancer (NSCLC)KRAS-mutant Pancreatic Ductal Adenocarcinoma (PDAC)KRAS-mutant Colorectal Cancer (CRC)+1 more
Kestrel Therapeutics, Inc. 145
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