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Results for “Advanced or Metastatic Solid Malignancies”

1,337 trials

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Showing 20 of 1,337 results

Early research (Phase 1)Ended earlyNCT04835714
What this trial is testing

Find a Safe and Effective Dose of BI 1701963 Alone and in Combination With BI 3011441 in Patients With Advanced Cancer and a Certain Mutation (Kirsten Rat Sarcoma Viral Oncogene Homologue [KRAS])

Who this might be right for
Solid Tumors, KRAS Mutation
Boehringer Ingelheim 8
Early research (Phase 1)Looking for participantsNCT05857332
What this trial is testing

SG1906 for CLDN18.2-Positive Solid Tumors

Who this might be right for
Locally Advanced Unresectable or Metastatic Solid Tumors
Hangzhou Sumgen Biotech Co., Ltd. 60
Testing effectiveness (Phase 2)Study completedNCT00526045
What this trial is testing

Phase I-II Study to Determine the Maximum Tolerated Dose (MTD) of AUY922 in Advanced Solid Malignancies, and Efficacy in HER2+ or ER+ Locally Advanced or Metastatic Breast Cancer Patients

Who this might be right for
Breast CancerHematologic Neoplasms
Novartis Pharmaceuticals 117
Testing effectiveness (Phase 2)Active Not RecruitingNCT04902872
What this trial is testing

Study of CBX-12 in Subjects With Advanced or Metastatic Refractory Solid Tumors

Who this might be right for
Solid Tumor, AdultEpithelial Ovarian CancerSmall Cell Lung Carcinoma+9 more
Cybrexa Therapeutics 130
Early research (Phase 1)Study completedNCT04094506
What this trial is testing

Study of ASP1948, Targeting an Immune Modulatory Receptor, in Japanese Patients With Advanced Solid Tumors

Who this might be right for
Locally Advanced (Unresectable) or Metastatic Solid Tumor Malignancies
Astellas Pharma Inc 9
Early research (Phase 1)Study completedNCT02004106
What this trial is testing

Evaluate Safety, Pharmacokinetics, and Efficacy of RO6895882 in Participants With Advanced and/or Metastatic Solid Tumors

Who this might be right for
Neoplasms
Hoffmann-La Roche 110
Early research (Phase 1)Looking for participantsNCT06349408
What this trial is testing

IBI3001 in Participants With Unresectable, Locally Advanced or Metastatic Solid Tumors

Who this might be right for
Locally Advanced Solid Tumor
Innovent Biologics (Suzhou) Co. Ltd. 250
Early research (Phase 1)Looking for participantsNCT05791448
What this trial is testing

AU409 for the Treatment of Advanced Primary Liver Cancers or Solid Tumor With Liver Metastatic Disease

Who this might be right for
Advanced CholangiocarcinomaAdvanced Hepatocellular CarcinomaAdvanced Malignant Solid Neoplasm+4 more
University of Southern California 36
Testing effectiveness (Phase 2)UnknownNCT03961698
What this trial is testing

Evaluation of IPI-549 Combined With Front-line Treatments in Pts. With Triple-Negative Breast Cancer or Renal Cell Carcinoma

Who this might be right for
Breast CancerRenal Cell Carcinoma
Infinity Pharmaceuticals, Inc. 91
Early research (Phase 1)Study completedNCT03009214
What this trial is testing

A Safety and Pharmacokinetic Phase I/Ib Study of AMC303 in Patients With Solid Tumours

Who this might be right for
Malignant Solid Tumor
amcure GmbH 55
Not applicableLooking for participantsNCT06887348
What this trial is testing

Assess the Long-term Safety Outcomes in Patients Previously Treated With RP1, RP2, or RP3

Who this might be right for
MelanomaMetastatic MelanomaAdvanced Solid Tumor+1 more
Replimune Inc. 50
Early research (Phase 1)Looking for participantsNCT04693468
What this trial is testing

Talazoparib and Palbociclib, Axitinib, or Crizotinib for the Treatment of Advanced or Metastatic Solid Tumors, TalaCom Trial

Who this might be right for
Advanced Malignant Solid NeoplasmMetastatic Malignant Solid NeoplasmRecurrent Malignant Solid Neoplasm
M.D. Anderson Cancer Center 111
Testing effectiveness (Phase 2)Active Not RecruitingNCT04706715
What this trial is testing

LAG3 PET Imaging in Advanced Solid Tumors

Who this might be right for
Metastatic Solid Tumor
University Medical Center Groningen 41
Testing effectiveness (Phase 2)Ended earlyNCT04157517
What this trial is testing

Modakafusp Alfa (TAK-573) Given by Itself and Together With Pembrolizumab in Adults With Advanced or Metastatic Solid Tumors

Who this might be right for
NeoplasmsMelanoma
Teva Branded Pharmaceutical Products R&D LLC 45
Testing effectiveness (Phase 2)Study completedNCT04021043
What this trial is testing

BMS-986156, Ipilimumab, and Nivolumab With or Without Stereotactic Body Radiation Therapy in Treating Patients With Advanced or Metastatic Lung/Chest or Liver Cancers

Who this might be right for
Advanced Malignant Solid NeoplasmMetastatic Carcinoma in the LiverMetastatic Carcinoma in the Lung+2 more
M.D. Anderson Cancer Center 51
Early research (Phase 1)Study completedNCT00126620
What this trial is testing

Sorafenib and Erlotinib in Treating Patients With Metastatic or Unresectable Solid Tumors

Who this might be right for
Unspecified Adult Solid Tumor, Protocol Specific
University Health Network, Toronto 17
Early research (Phase 1)Study completedNCT00504296
What this trial is testing

SB939 in Treating Patients With Locally Advanced or Metastatic Solid Tumors

Who this might be right for
Unspecified Adult Solid Tumor, Protocol Specific
NCIC Clinical Trials Group 39
Early research (Phase 1)Ended earlyNCT06299761
What this trial is testing

Study of the RNR Inhibitor BBI-825 in Subjects With Tumors With Resistance Gene Amplifications

Who this might be right for
Solid Tumor
Boundless Bio 19
Early research (Phase 1)Study completedNCT00968981
What this trial is testing

Hedgehog Pathway Inhibitor GDC-0449 in Patients With Locally Advanced or Metastatic Solid Tumors That Are Refractory to Standard Therapy or for Whom No Standard Therapy Exists

Who this might be right for
Solid Cancers
Genentech, Inc. 67
Early research (Phase 1)Study completedNCT02650713
What this trial is testing

The Safety, Pharmacokinetics, and Therapeutic Activity of RO6958688 in Combination With Atezolizumab in Participants With Locally Advanced and/or Metastatic Carcinoembryonic Antigen (CEA)-Positive Solid Tumors

Who this might be right for
Solid Tumors
Hoffmann-La Roche 228
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