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Results for “Aggressive Systemic Mastocytosis (ASM)”

18 trials

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Showing 18 of 18 results

Early research (Phase 1)Ended earlyNCT05609942
What this trial is testing

Study of Elenestinib (BLU-263) in Advanced Systemic Mastocytosis (AdvSM) and and Other KIT Altered Hematologic Malignancies

Who this might be right for
Advanced Systemic Mastocytosis
Blueprint Medicines Corporation 9
Not applicableStudy completedNCT04695431
What this trial is testing

Retrospective Study Assessing the Effect of Avapritinib Versus Best Available Therapy in Patients With AdvSM

Who this might be right for
Advanced Systemic MastocytosisAggressive Systemic MastocytosisSystemic Mastocytosis With an Associated Hematological Neoplasm+1 more
Blueprint Medicines Corporation 317
Not applicableStudy completedNCT00769587
What this trial is testing

Thalidomide in Treating Patients With Relapsed or Progressive Systemic Mastocytosis

Who this might be right for
Non Neoplastic ConditionPrecancerous Condition
Centre Hospitalier Universitaire, Amiens
Testing effectiveness (Phase 2)Study completedNCT00233454
What this trial is testing

Phase 2 Midostaurin in Aggressive Systemic Mastocytosis and Mast Cell Leukemia

Who this might be right for
Systemic Mastocytosis, Aggressive (ASM)Leukemia, Mast CellHematological Non-mast Cell Lineage Disease (AHNMD)
Jason Robert Gotlib 26
Post-approval studies (Phase 4)Looking for participantsNCT06748001
What this trial is testing

Avapritinib Rollover Study

Who this might be right for
Mastocytosis, Systemic
Blueprint Medicines Corporation 60
Not applicableStudy completedNCT02620254
What this trial is testing

Mast Cell Connect: A Registry for Patients With Mastocytosis

Who this might be right for
Mastocytosis
Blueprint Medicines Corporation 743
Large-scale testing (Phase 3)UnknownNCT01602939
What this trial is testing

Cladribine Plus Pegylated Interpheron Alfa-2a in Systemic Mastocytosis

Who this might be right for
Systemic Mastocytosis
Hospital Virgen de la Salud 10
Testing effectiveness (Phase 2)Ended earlyNCT03214666
What this trial is testing

GTB-3550 Tri-Specific Killer Engager (TriKE®) for High Risk Hematological Malignancies

Who this might be right for
High-risk Myelodysplastic SyndromesAcute Myelogenous LeukemiaSystemic Mastocytosis+1 more
GT Biopharma, Inc. 12
Not applicableStudy completedNCT02380222
What this trial is testing

Patient-Reported Outcome Questionnaire for Systemic Mastocytosis

Who this might be right for
Aggressive Systemic Mastocytosis (ASM)SM w Assoc Clonal Hema Non-mast Cell Lineage Disease (SM-AHNMD)Mast Cell Leukemia (MCL)+2 more
Adelphi Values LLC 5
Testing effectiveness (Phase 2)Study completedNCT00782067
What this trial is testing

Efficacy and Safety of Midostaurin in Patients With Aggressive Systemic Mastocytosis or Mast Cell Leukemia

Who this might be right for
Leukemia
Novartis Pharmaceuticals 116
Not applicableNo Longer AvailableNCT05219266
What this trial is testing

Managed Access Programs for PKC412, Midostaurin

Who this might be right for
FMS-Like Tyrosine Kinase 3 (FLT3)-Mutated Acute Myeloid LeukemiaAcute Myeloid LeukemiaAggressive Systemic Mastocytosis+2 more
Novartis Pharmaceuticals
Not applicableAvailableNCT06915766
What this trial is testing

Expanded Access to Bezuclastinib for Patients With NonAdvanced Systemic Mastocytosis or Advanced Systemic Mastocytosis

Who this might be right for
Systemic Mastocytoses, IndolentSystemic Mastocytoses, Aggressive
Cogent Biosciences, Inc.
Testing effectiveness (Phase 2)Ended earlyNCT02415608
What this trial is testing

Ibrutinib in Treating Patients With Advanced Systemic Mastocytosis

Who this might be right for
Aggressive Systemic MastocytosisMast Cell LeukemiaSystemic Mastocytosis
Jason Robert Gotlib 4
Early research (Phase 1)Study completedNCT02571036
What this trial is testing

A Safety, Tolerability and PK Study of DCC-2618 in Patients With Advanced Malignancies

Who this might be right for
Gastrointestinal Stromal TumorsAdvanced Systemic MastocytosisAdvanced Cancers
Deciphera Pharmaceuticals, LLC 282
Early research (Phase 1)Study completedNCT02561988
What this trial is testing

(EXPLORER) Study of BLU-285 in Patients With Advanced Systemic Mastocytosis (AdvSM) and Relapsed or Refractory Myeloid Malignancies

Who this might be right for
Aggressive Systemic MastocytosisSystemic Mastocytosis-associated Hematologic Non-mast Cell DiseaseMast Cell Leukemia+1 more
Blueprint Medicines Corporation 86
Testing effectiveness (Phase 2)Study completedNCT01807598
What this trial is testing

Brentuximab Vedotin in Treating Patients With Advanced Systemic Mastocytosis or Mast Cell Leukemia

Who this might be right for
Aggressive Systemic MastocytosisMast Cell LeukemiaSystemic Mastocytosis
Jason Robert Gotlib 10
Testing effectiveness (Phase 2)Looking for participantsNCT04996875
What this trial is testing

(Apex) Bezuclastinib in Patients With Advanced Systemic Mastocytosis

Who this might be right for
Advanced Systemic Mastocytosis (AdvSM)SM With an Associated Hematologic Neoplasm (SM-AHN)Mast Cell Leukemia (MCL)+1 more
Cogent Biosciences, Inc. 140
Testing effectiveness (Phase 2)Study completedNCT03580655
What this trial is testing

(PATHFINDER) Study to Evaluate Efficacy and Safety of Avapritinib (BLU-285), A Selective KIT Mutation-targeted Tyrosine Kinase Inhibitor, in Patients With Advanced Systemic Mastocytosis

Who this might be right for
Advanced Systemic MastocytosisAggressive Systemic MastocytosisSystemic Mastocytosis With an Associated Hematologic Neoplasm+1 more
Blueprint Medicines Corporation 107