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Results for “Alpha-1 Antitrypsin Deficiency-associated Lung Disease”

17 trials

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Showing 17 of 17 results

Large-scale testing (Phase 3)Looking for participantsNCT06165341
What this trial is testing

Study to Learn About the Safety of Fazirsiran and if it Can Help People With Alpha-1 Antitrypsin Liver Disease With Mild Liver Scarring (Fibrosis)

Who this might be right for
Alpha1-Antitrypsin Deficiency
Takeda 50
Testing effectiveness (Phase 2)WithdrawnNCT06622668
What this trial is testing

NTLA-3001 in Adults with Alpha-1 Antitrypsin Deficiency-Associated Lung Disease

Who this might be right for
Lung DiseasePulmonary DiseaseAATD+2 more
Intellia Therapeutics
Testing effectiveness (Phase 2)Ended earlyNCT04764448
What this trial is testing

Belcesiran in Patients With AATLD

Who this might be right for
Alpha 1-Antitrypsin Deficiency
Dicerna Pharmaceuticals, Inc., a Novo Nordisk company 16
Not applicableUnknownNCT00700934
What this trial is testing

Management of Patients With Alpha-1 Antitrypsin Deficiency Associated Emphysema

Who this might be right for
Alpha 1-Antitrypsin DeficiencyEmphysema
Assistance Publique - Hôpitaux de Paris 300
Large-scale testing (Phase 3)Looking for participantsNCT05677971
What this trial is testing

Study to Check the Safety of Fazirsiran and Learn if Fazirsiran Can Help People With Liver Disease and Scarring (Fibrosis) Due to an Abnormal Version of Alpha-1 Antitrypsin Protein

Who this might be right for
Alpha1-Antitrypsin Deficiency
Takeda 160
Testing effectiveness (Phase 2)WithdrawnNCT05146882
What this trial is testing

An Extension Study of Belcesiran in Patients With Alpha-1 Antitrypsin Deficiency Associated Liver Disease (AATLD)

Who this might be right for
Alpha 1-Antitrypsin Deficiency
Dicerna Pharmaceuticals, Inc., a Novo Nordisk company
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07227207
What this trial is testing

TSRA-196 in Adults With PiZZ Alpha-1 Antitrypsin Deficiency (AATD)

Who this might be right for
Alpha-1 Antitrypsin Deficiency (AATD)
Tessera Therapeutics, Inc. 72
Testing effectiveness (Phase 2)Study completedNCT03679598
What this trial is testing

Alvelestat (MPH966) for the Treatment of ALpha-1 ANTitrypsin Deficiency

Who this might be right for
Alpha-1 Antitrypsin Deficiency (AATD)Pi*ZZ, Pi*SZ, Pi*Null, Another Rare Phenotype/Genotype Known to be Associated With Either Low or Functionally Impaired AAT Including F or I MutationsEmphysema or COPD
University of Alabama at Birmingham 63
Testing effectiveness (Phase 2)Study completedNCT01054339
What this trial is testing

Safety & Efficacy Study of rAAV1-CB-hAAT for Alpha-1 Antitrypsin Deficiency

Who this might be right for
Alpha-1 Antitrypsin Deficiency
Beacon Therapeutics 9
Not applicableStudy completedNCT00001885
What this trial is testing

Identification of Genes Associated With Lung Disease in Patients With Rheumatoid Arthritis

Who this might be right for
HealthyPulmonary FibrosisRheumatoid Arthritis
National Heart, Lung, and Blood Institute (NHLBI) 400
Testing effectiveness (Phase 2)Study completedNCT02168686
What this trial is testing

Safety Dose Finding Study of ADVM-043 Gene Therapy to Treat Alpha-1 Antitrypsin (A1AT) Deficiency

Who this might be right for
Alpha 1-Antitrypsin Deficiency
Adverum Biotechnologies, Inc. 6
Testing effectiveness (Phase 2)Study completedNCT03946449
What this trial is testing

Study of Fazirsiran (TAK-999, ARO-AAT) in Patients With Alpha-1 Antitrypsin Deficiency Associated Liver Disease (AATD)

Who this might be right for
Alpha 1-Antitrypsin Deficiency
Arrowhead Pharmaceuticals 16
Testing effectiveness (Phase 2)Looking for participantsNCT06389877
What this trial is testing

Evaluate the Safety and Efficacy of BEAM-302 in Adult Patients With Alpha-1 Antitrypsin Deficiency (AATD)

Who this might be right for
Alpha 1-Antitrypsin Deficiency
Beam Therapeutics Inc. 106
Early research (Phase 1)Study completedNCT00430768
What this trial is testing

Experimental Gene Transfer Procedure to Treat Alpha 1-Antitrypsin (AAT) Deficiency

Who this might be right for
Alpha 1-Antitrypsin Deficiency
University of Massachusetts, Worcester 9
Very early researchStudy completedNCT00377416
What this trial is testing

Experimental Gene Transfer Procedure to Treat Alpha 1-Antitrypsin Deficiency

Who this might be right for
Alpha 1-Antitrypsin Deficiency
University of Massachusetts, Worcester 12
Not applicableLooking for participantsNCT06512454
What this trial is testing

A Study in Adults to Learn About Inherited Alpha-1 Antitrypsin Deficiency (AATD) and AATD Related Liver Problems

Who this might be right for
Alpha1-Antitrypsin Deficiency
Takeda 500
Large-scale testing (Phase 3)Active Not RecruitingNCT05899673
What this trial is testing

An Extension Study to Learn About the Long-Term Safety of Fazirsiran and if Fazirsiran Can Help People With Alpha-1 Antitrypsin Liver Disease

Who this might be right for
Alpha1-Antitrypsin Deficiency
Takeda 31