Early research (Phase 1)Study completedNCT04208152What this trial is testingA First-in-Human Study of Single and Multiple Doses of anle138b in Healthy SubjectsWho this might be right forHealthy Volunteers MODAG GmbH 68
Not applicableStudy completedNCT05638815What this trial is testingAn Observational Study of Parkinson's Disease and Other Synucleinopathies (EASE-PD)Who this might be right forParkinson's DiseaseMultiple System Atrophy SciNeuro 89
Not applicableEnded earlyNCT04020198What this trial is testingA Pilot Biomarker Study Assessing Alpha-synuclein Aggregates Across Biofluid Reservoirs in Patients With SynucleinopathiesWho this might be right forParkinson DiseaseMultiple System AtrophyRapid Eye Movement Sleep Behavior Disorder+1 more Stony Brook University 8
Not applicableLooking for participantsNCT07428447What this trial is testingAnalysis of Cutaneous Phosphorylated Alpha-Synuclein to Identify Patients at Risk of Progressing From Essential Tremor to Parkinson's DiseaseWho this might be right forEssential Tremor, Movement DisordersEssential TremorEssential Tremor-plus CND Life Sciences 300
Not applicableLooking for participantsNCT07498686What this trial is testingPlasma a-Synuclein Aggregation Seeding Activity as a Novel Biomarker for Neurodegeneration DiseaseWho this might be right forRT-QuIC Xuanwu Hospital, Beijing 458
Not applicableLooking for participantsNCT05740683What this trial is testingAlpha-synuclein Rt-quic and Neurologic Symptoms in Persons With idiOpathic anosMiAWho this might be right forIdiopathic AnosmiaIdiopathic HyposmiaIdiopathic Olfactory Dysfunction Danish Dementia Research Centre 100
Not applicableStudy completedNCT03156647What this trial is testingAlpha-synuclein Level in Saliva to Differentiate Between Idiopathic Parkinson Disease and Iatrogenic Parkinsonian SyndromeWho this might be right forParkinson DiseaseParkinsonian Disorders Centre Hospitalier Universitaire de Nīmes 80
Very early researchStudy completedNCT06445465What this trial is testingStudy to Evaluate a Potential PET Radioligand for Imaging Alpha-synuclein Deposits in the BrainWho this might be right forAlpha-SynucleinopathyParkinson's DiseaseDementia With Lewy Bodies+1 more Invicro 12
Not applicableNot Yet RecruitingNCT07474779What this trial is testingUnderstanding Alpha-Synuclein Spread in Parkinson's Disease Through Blood Biomarkers and NeuroimagingWho this might be right forParkinson's Disease (PD)GBA1 Parkinson DiseaseREM Sleep Behavior Disorder (iRBD) University of Pavia 160
Not applicableLooking for participantsNCT06528964What this trial is testingProteinopathies Expression in Skin of Neurodegenerative DisordersWho this might be right forAlzheimer DiseaseFrontotemporal DementiaParkinson Disease+3 more Universidad Autonoma de San Luis Potosí 40
Early research (Phase 1)Study completedNCT04685265What this trial is testingAssess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of anle138b in Parkinson's DiseaseWho this might be right forParkinson Disease MODAG GmbH 70
Not applicableUnknownNCT02114242What this trial is testingBiomarkers in Parkinsonian SyndromesWho this might be right forParkinsonian SyndromesParkinson's DiseaseMultiple System Atrophy+1 more University Hospital, Bordeaux 100
Not applicableUnknownNCT04264273What this trial is testingDiagnosis of Parkinson´s Disease by Means of Submandibular Gland Needle BiopsyWho this might be right forParkinson Disease Universität des Saarlandes 60
Not applicableUnknownNCT04062279What this trial is testingPredictors of Parkinson's Disease ProgressionWho this might be right forParkinson DiseaseCognitive DysfunctionBiomarkers Ain Shams University 100
Early research (Phase 1)Study completedNCT05532358What this trial is testingA Drug-Drug Interaction Study to Assess the CYP1A2 and CYP3A4 Interaction Potential of TEV-56286 (anle138b)Who this might be right forHealthy Volunteers MODAG GmbH 54
Not applicableStudy completedNCT05067192What this trial is testingOptimization of Morphomer-based Alpha-synuclein PET TracersWho this might be right forParkinson DiseaseDementia With Lewy BodiesMultiple System Atrophy+2 more Skane University Hospital 12
Not applicableWithdrawnNCT04266457What this trial is testingEstablishing Alpha-synuclein RT-QuIC Assay as a Diagnostic Technique in REM Sleep Behaviour DisorderWho this might be right forSleep Disorder Rem Sleep BehaviorParkinson's Disease, Lewy Body University of Edinburgh
Not applicableStudy completedNCT02572713What this trial is testingSystemic Synuclein Sampling Study (S4)Who this might be right forParkinson's Disease Michael J. Fox Foundation for Parkinson's Research 80
Testing effectiveness (Phase 2)Active Not RecruitingNCT05670782What this trial is testingEvaluate Safety and Efficacy of KM-819 in Healthy Adults and Participants with Parkinson's DiseaseWho this might be right forParkinson Disease FAScinate Therapeutics Inc. 314
Not applicableStudy completedNCT02923297What this trial is testingGALIG Gene Expression in Parkinson's DiseaseWho this might be right forParkinson Disease Centre Hospitalier Régional d'Orléans 37