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Results for “Alpha1 Anti-Trypsin Deficiency”

141 trials

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Showing 20 of 141 results

Testing effectiveness (Phase 2)Study completedNCT03945292
What this trial is testing

Safety, Tolerability and Pharmacodynamic Effect of Fazirsiran (TAK-999, ARO-AAT)

Who this might be right for
Alpha 1-Antitrypsin Deficiency
Arrowhead Pharmaceuticals 40
Large-scale testing (Phase 3)Ended earlyNCT01731691
What this trial is testing

Safety and Efficacy of (α1Proteinase Inhibitor, α1PI) in HIV Disease

Who this might be right for
HIV Disease
Institute for Human Genetics and Biochemistry 12
Not applicableStudy completedNCT00001885
What this trial is testing

Identification of Genes Associated With Lung Disease in Patients With Rheumatoid Arthritis

Who this might be right for
HealthyPulmonary FibrosisRheumatoid Arthritis
National Heart, Lung, and Blood Institute (NHLBI) 400
Not applicableLooking for participantsNCT06505603
What this trial is testing

PiMZ Longitudinal Cohort (PiMZ Logic)

Who this might be right for
Alpha 1-Antitrypsin DeficiencyEmphysema or COPD
Columbia University 80
Not applicableStudy completedNCT02547532
What this trial is testing

Microbioma in Sputa From COPD With Alpha-1 Antitrypsin Deficiency

Who this might be right for
Alpha-1 Antitrypsin Deficiency
Fondazione Salvatore Maugeri 100
Post-approval studies (Phase 4)WithdrawnNCT04440488
What this trial is testing

ARALAST NP Alpha-1 Lung Density Chronic Obstructive Pulmonary Disease-Emphysema (COPD-E) Study

Who this might be right for
Chronic Obstructive Pulmonary DiseaseAlpha1-antitrypsin Deficiency
Shire
Not applicableStudy completedNCT01615484
What this trial is testing

Ex-vivo Perfusion and Ventilation of Lungs Recovered From Non-Heart-Beating Donors to Assess Transplant Suitability

Who this might be right for
EmphysemaChronic Obstructive Pulmonary Disease (COPD)Cystic Fibrosis+5 more
University of North Carolina, Chapel Hill 24
Testing effectiveness (Phase 2)Active Not RecruitingNCT06677307
What this trial is testing

A Phase 1/2a, Single- and Multiple-dose Escalation Study of KRRO-110

Who this might be right for
Alpha-1 Anti-trypsin DeficiencyAATD
Korro Bio, Inc. 64
Post-approval studies (Phase 4)Study completedNCT00396006
What this trial is testing

Efficacy and Safety Study of Augmentation Therapy With ARALAST Fraction IV-1 (Human Alpha 1 - Proteinase Inhibitor)

Who this might be right for
Alpha 1-Antitrypsin Deficiency
Baxalta now part of Shire 21
Testing effectiveness (Phase 2)Study completedNCT02001688
What this trial is testing

Phase II, Safety and Efficacy Study of Kamada-alpha-1-antitrypsin (AAT) for Inhalation"

Who this might be right for
Alpha-1 Antitrypsin Deficiency
Kamada, Ltd. 36
Early research (Phase 1)Ended earlyNCT02503683
What this trial is testing

An Investigational Drug, ALN-AAT, in Healthy Adult Subjects and Patients With ZZ Type Alpha-1 Antitrypsin Deficiency Liver Disease

Who this might be right for
Antitrypsin Deficiency Liver Disease
Alnylam Pharmaceuticals 26
Not applicableLooking for participantsNCT07152834
What this trial is testing

Screening for Alpha-1 Antitrypsin Deficiency in Patients With Airway Obstruction

Who this might be right for
Alpha 1-antitrypsin Deficiency (AATD)
Muğla Sıtkı Koçman University 734
Testing effectiveness (Phase 2)WithdrawnNCT01183455
What this trial is testing

A Research Trial of Aralast NP in New Onset Diabetes (RETAIN) - Part II

Who this might be right for
Diabetes Mellitus, Type 1
National Institute of Allergy and Infectious Diseases (NIAID)
Large-scale testing (Phase 3)Looking for participantsNCT05677971
What this trial is testing

Study to Check the Safety of Fazirsiran and Learn if Fazirsiran Can Help People With Liver Disease and Scarring (Fibrosis) Due to an Abnormal Version of Alpha-1 Antitrypsin Protein

Who this might be right for
Alpha1-Antitrypsin Deficiency
Takeda 160
Testing effectiveness (Phase 2)Ended earlyNCT05643495
What this trial is testing

Evaluate Efficacy and Safety of VX-864 in Participants With the PiZZ Genotype

Who this might be right for
Alpha-1 Antitrypsin Deficiency
Vertex Pharmaceuticals Incorporated 14
Early research (Phase 1)Study completedNCT00242385
What this trial is testing

Pharmacokinetic Study of ARALAST (Human Alpha1- PI)

Who this might be right for
Alpha 1-Antitrypsin Deficiency
Baxalta now part of Shire 25
Not applicableWithdrawnNCT02273349
What this trial is testing

Lung Volume Reduction Coils for Emphysema in Alpha-1 Antitrypsin Deficiency

Who this might be right for
Alpha-1-Antitrypsin DeficiencyChronic Obstructive Lung DiseaseEmphysema
University Hospital, Saarland
Large-scale testing (Phase 3)Study completedNCT01370018
What this trial is testing

Therapy to Elevate CD4 Counts in HIV-1 Disease

Who this might be right for
HIV Disease
Institute for Human Genetics and Biochemistry 4
Not applicableNot Yet RecruitingNCT06029543
What this trial is testing

Permian Health Women's Lung Health Study

Who this might be right for
COPDLung Function DecreasedAlpha 1-Antitrypsin
Permian Health Lung Institute 350
Not applicableUnknownNCT03285100
What this trial is testing

The Effects of Discontinuation of Vitamin K Antagonists on the Rate of Elastin Degradation

Who this might be right for
Emphysema or COPDAneurysmCystic Fibrosis+1 more
Canisius-Wilhelmina Hospital 30
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