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Results for “Alpha1-antitrypsin Deficiency”

139 trials

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Showing 20 of 139 results

Not applicableEnded earlyNCT03823443
What this trial is testing

COPD Exacerbation Blood and Urine Biomarkers Study

Who this might be right for
Chronic Obstructive Pulmonary DiseaseAcute Exacerbation CopdAlpha-1 Anti-trypsin Deficiency
Columbia University 7
Not applicableStudy completedNCT01831739
What this trial is testing

Genomic Research in Sarcoidosis

Who this might be right for
Sarcoidosis
University of Pittsburgh 368
Early research (Phase 1)Study completedNCT03362242
What this trial is testing

Study of ARO-AAT in Normal Adult Volunteers

Who this might be right for
Alpha 1-Antitrypsin Deficiency
Arrowhead Pharmaceuticals 45
Post-approval studies (Phase 4)Study completedNCT01651351
What this trial is testing

GLASSIA Infusion Rate Study

Who this might be right for
Alpha1-antitrypsin DeficiencyHealthy Volunteers
Baxalta now part of Shire 30
Early research (Phase 1)Study completedNCT05727800
What this trial is testing

A Phase 1, First-in-human Study of VX-668

Who this might be right for
Alpha-1 Antitrypsin Deficiency
Vertex Pharmaceuticals Incorporated 114
Large-scale testing (Phase 3)Study completedNCT01217671
What this trial is testing

International Study Evaluating the Safety and Efficacy of Inhaled, Human, Alpha-1 Antitrypsin (AAT) in Alpha-1 Antitrypsin Deficient Patients With Emphysema

Who this might be right for
Emphysema
Kamada, Ltd. 168
Large-scale testing (Phase 3)Study completedNCT00301366
What this trial is testing

The Safety and Tolerability of Alpha-1 Modified Process (MP) In Subjects With Alpha-1-antitrypsin (AAT) Deficiency

Who this might be right for
Alpha 1-Antitrypsin Deficiency
Grifols Therapeutics LLC 38
Early research (Phase 1)Ended earlyNCT01183468
What this trial is testing

A Research Trial of Aralast in New Onset Diabetes (RETAIN)

Who this might be right for
Diabetes Mellitus, Type 1
National Institute of Allergy and Infectious Diseases (NIAID) 17
Not applicableEnrolling By InvitationNCT06892236
What this trial is testing

Preparation of IPSC for Cell Gene Editing for the Treatment of AATD

Who this might be right for
Alpha1-antitrypsin Deficiency
Fondazione IRCCS Policlinico San Matteo di Pavia 3
Not applicableEnded earlyNCT02502201
What this trial is testing

Environment Effect on Six-Minute Walk Test Performance

Who this might be right for
Chronic Obstructive Pulmonary DiseaseAlpha-1 Antitrypsin Deficiency
University of Florida 27
Not applicableLooking for participantsNCT00500123
What this trial is testing

The Alpha-1 Foundation's and University of Florida's Alpha-1 Coded Testing (ACT) Study

Who this might be right for
Alpha-1 Antitrypsin Deficiency
University of Florida 50,000
Testing effectiveness (Phase 2)WithdrawnNCT02900183
What this trial is testing

Safety, Tolerability and Effect of ARC-AAT Injection on Circulating and Intrahepatic Alpha-1 Antitrypsin Levels

Who this might be right for
Alpha-1 Antitrypsin Deficiency
Arrowhead Pharmaceuticals
Not applicableStudy completedNCT00001462
What this trial is testing

Characterization of the Pathobiology of Early Lung Destruction in Alpha 1-Antitrypsin Deficient Individuals

Who this might be right for
EmphysemaLung Diseases, ObstructiveAlpha 1-Antitrypsin Deficiency
National Heart, Lung, and Blood Institute (NHLBI) 60
Not applicableLooking for participantsNCT03455686
What this trial is testing

Exploring the Utility of Hyperpolarized 129Xe MRI in Healthy Volunteers and Patients With Lung Disease

Who this might be right for
AsthmaChronic Obstructive Pulmonary DiseaseBronchiectasis+5 more
McMaster University 60
Testing effectiveness (Phase 2)Study completedNCT03636347
What this trial is testing

A 12-week Study Treating Participants Who Have alpha1-antitrypsin-related COPD With Alvelestat (MPH966) or Placebo.

Who this might be right for
Alpha 1-Antitrypsin DeficiencyEmphysemaCOPD
Mereo BioPharma 99
Large-scale testing (Phase 3)Study completedNCT02525861
What this trial is testing

GLASSIA Safety, Immunogenicity, and Bronchoalveolar Lavage Study

Who this might be right for
Alpha1-antitrypsin Deficiency
Baxalta now part of Shire 34
Not applicableUnknownNCT04966221
What this trial is testing

Functional and Structural Lung Imaging in Chronic Obstructive Pulmonary Disease

Who this might be right for
Chronic Obstructive Pulmonary DiseaseAlpha 1-Antitrypsin Deficiency
University of Nottingham 75
Testing effectiveness (Phase 2)Study completedNCT02947087
What this trial is testing

Alpha-1 Antitrypsin (AAT) Enhances Islet Autograft Survival in Patients With Chronic Pancreatitis

Who this might be right for
Chronic Pancreatitis
Medical University of South Carolina 48
Testing effectiveness (Phase 2)Looking for participantsNCT05897424
What this trial is testing

Long-term, Open-label Study of SAR447537 (INBRX-101) in Adults With Alpha-1 Antitrypsin Deficiency Emphysema

Who this might be right for
Alpha 1-Antitrypsin DeficiencyEmphysema
Sanofi 185
Post-approval studies (Phase 4)Looking for participantsNCT07135427
What this trial is testing

Genetic Variation in IgG in Alpha 1 Antitrypsin Deficiency

Who this might be right for
Alpha 1-AntitrypsinCOPDAntibody Deficiency
University of Alabama at Birmingham 30
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