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Results for “Alzheimer's Disease in Down Syndrome”

28 trials

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Showing 20 of 28 results

Large-scale testing (Phase 3)Looking for participantsNCT04390646
What this trial is testing

GnRH Therapy on Cognition in Down Syndrome

Who this might be right for
Down SyndromeCognitive DeclineAlzheimer Disease, Early Onset+1 more
Nelly Pitteloud 56
Large-scale testing (Phase 3)UnknownNCT00056329
What this trial is testing

Vitamin E in Aging Persons With Down Syndrome

Who this might be right for
Down SyndromeAlzheimer Disease
New York State Institute for Basic Research 350
Not applicableEnded earlyNCT04149197
What this trial is testing

Down Syndrome Clinical Trials - Study of Alzheimer's Disease in Down Syndrome

Who this might be right for
Alzheimer's Disease in Down Syndrome
LuMind IDSC Foundation 252
Large-scale testing (Phase 3)Study completedNCT01594346
What this trial is testing

Multicenter Vitamin E Trial in Aging Persons With Down Syndrome

Who this might be right for
Alzheimer's DiseaseDown Syndrome
New York State Institute for Basic Research 349
Post-approval studies (Phase 4)Not Yet RecruitingNCT06911944
What this trial is testing

Amyloid Lowering for Alzheimer's in Down's With Donanemab Investigation

Who this might be right for
Down Syndrome (DS)Down Syndrome (Trisomy 21)Alzheimer Disease+1 more
Michael Rafii, MD, PhD 60
Early research (Phase 1)Looking for participantsNCT06206824
What this trial is testing

Leucettinib-21 First-in-Human Phase 1 in Healthy Volunteers and Subjects With Down Syndrome and Alzheimer's Disease

Who this might be right for
Healthy VolunteersDown SyndromeAlzheimer's Disease
Perha Pharmaceuticals 164
Early research (Phase 1)Ended earlyNCT06673069
What this trial is testing

Hero: A Study to Evaluate the Safety, Tolerability, and Pharmacokinetics (PK) and Pharmacodynamics (PD) of ION269 in Participants With Down Syndrome (DS) at Risk for Alzheimer's Disease (AD)

Who this might be right for
Alzheimer DiseaseDown Syndrome
Ionis Pharmaceuticals, Inc. 1
Testing effectiveness (Phase 2)Looking for participantsNCT05462106
What this trial is testing

Assess the Effects of ACI-24.060 in Alzheimer's Disease and in Down Syndrome (ABATE Study)

Who this might be right for
Amyloid PlaqueBeta-AmyloidDSAD+2 more
AC Immune SA 176
Not applicableLooking for participantsNCT05196984
What this trial is testing

Gamma Frequency Stimulation in Individuals With Down Syndrome

Who this might be right for
Down Syndrome
Massachusetts Institute of Technology 60
Not applicableUnknownNCT00966017
What this trial is testing

Glucose Metabolic, Amyloid, and Tau Brain Imaging in Down Syndrome and Dementia

Who this might be right for
Down SyndromeAlzheimer's Disease
National Institute on Aging (NIA) 108
Not applicableLooking for participantsNCT06740162
What this trial is testing

Physical Activity and Community EmPOWERment Project

Who this might be right for
Intellectual DisabilityNeurodevelopmental DisordersAutism Spectrum Disorder+10 more
University of North Carolina, Chapel Hill 376
Testing effectiveness (Phase 2)Study completedNCT01778946
What this trial is testing

Nicotine Treatment of Cognitive Decline in Down Syndrome

Who this might be right for
Down SyndromeMild Cognitive Impairment
Vanderbilt University Medical Center 7
Testing effectiveness (Phase 2)Study completedNCT01699711
What this trial is testing

Normalization of dyrk1A and APP Function as an Approach to Improve Cognitive Performance and Decelerate AD Progression in DS Subjects: Epigallocatechin Gallate as Therapeutic Tool

Who this might be right for
Down Syndrome (DS)
Parc de Salut Mar 87
Early research (Phase 1)Not Yet RecruitingNCT07278492
What this trial is testing

NAD Augmentation to Prevent or Reverse Alzheimer's Disease in People With Down Syndrome

Who this might be right for
Down Syndrome (DS)
Brigham and Women's Hospital 24
Not applicableUnknownNCT00965835
What this trial is testing

Amyloid Plaque and Tangle Imaging in Alzheimer's Disease and Down Syndrome

Who this might be right for
Down SyndromeAlzheimer's Disease
National Institute on Aging (NIA) 40
Large-scale testing (Phase 3)Ended earlyNCT06860373
What this trial is testing

LIFE-DSR-Biomarker Sub-study of Biomarkers in Down Syndrome Related Alzheimer's Disease (DS-AD)

Who this might be right for
Down Syndrome
LuMind IDSC Foundation 5
Not applicableStudy completedNCT01303133
What this trial is testing

Natural History of Amyloid Deposition in Adults With Down Syndrome

Who this might be right for
Down Syndrome
University of Pittsburgh 81
Not applicableStudy completedNCT06484426
What this trial is testing

Goal Attainment Scaling (GAS) Sub-Study

Who this might be right for
Alzheimer's Disease in Down Syndrome
LuMind IDSC Foundation 46
Not applicableLooking for participantsNCT05985486
What this trial is testing

Brain Outcomes With Lifestyle Change in Down Syndrome

Who this might be right for
Down SyndromeAlzheimer DiseaseObesity
University of Kansas Medical Center 81
Not applicableStudy completedNCT04048759
What this trial is testing

The Promotion of Physical Activity for the Prevention of Alzheimer's Disease in Adults With Down Syndrome

Who this might be right for
Down SyndromeAlzheimer Disease
University of Kansas Medical Center 81
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