Crick
HomeTrialsGenesDrugs23andMeGraphBlogContact
  • Home
  • Trials
  • Genes
  • Drugs
  • 23andMe
  • Graph
  • Blog
  • Contact
Crick

An open-source clinical intelligence platform. Explore clinical trials, gene networks, and molecular structures using public data sources.

Data Sources

  • ClinicalTrials.gov
  • OpenTargets
  • ClinVar
  • PubChem

Links

  • Contact
  • Privacy

© 2026 Crick. All rights reserved.

Crick is for educational purposes only. Not medical advice.

Results for “Alzheimer's Disease in Down Syndrome”

30 trials

Filters

Phase
Early Phase 1
Phase 1
Phase 2
Phase 3
Phase 4
Status
Recruiting
Active, Not Recruiting
Not Yet Recruiting
Completed
Enrolling by Invitation

Showing 20 of 30 results

Large-scale testing (Phase 3)Study completedNCT01594346
What this trial is testing

Multicenter Vitamin E Trial in Aging Persons With Down Syndrome

Who this might be right for
Alzheimer's DiseaseDown Syndrome
New York State Institute for Basic Research 349
Large-scale testing (Phase 3)UnknownNCT00056329
What this trial is testing

Vitamin E in Aging Persons With Down Syndrome

Who this might be right for
Down SyndromeAlzheimer Disease
New York State Institute for Basic Research 350
Not applicableNot Yet RecruitingNCT07047963
What this trial is testing

Neuropsychological Evaluation in Intellectual Disability (ENDI)

Who this might be right for
Down Syndrome (Trisomy 21)NeuropsychologyCognitive Aging+2 more
Central Hospital, Nancy, France 40
Testing effectiveness (Phase 2)Study completedNCT01778946
What this trial is testing

Nicotine Treatment of Cognitive Decline in Down Syndrome

Who this might be right for
Down SyndromeMild Cognitive Impairment
Vanderbilt University Medical Center 7
Not applicableStudy completedNCT01303133
What this trial is testing

Natural History of Amyloid Deposition in Adults With Down Syndrome

Who this might be right for
Down Syndrome
University of Pittsburgh 81
Large-scale testing (Phase 3)Looking for participantsNCT07234695
What this trial is testing

LEvetiracetam to Prevent Seizures in Symptomatic Alzheimer's Disease in Adults With Down Syndrome

Who this might be right for
Down SyndromeDown Syndrome (DS)Down Syndrome (Trisomy 21)+7 more
Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau 120
Not applicableLooking for participantsNCT03233646
What this trial is testing

Retinal Imaging in Neurodegenerative Disease

Who this might be right for
Alzheimer's DiseaseMild Cognitive ImpairmentParkinson's Disease+12 more
Duke University 2,000
Not applicableUnknownNCT00966017
What this trial is testing

Glucose Metabolic, Amyloid, and Tau Brain Imaging in Down Syndrome and Dementia

Who this might be right for
Down SyndromeAlzheimer's Disease
National Institute on Aging (NIA) 108
Early research (Phase 1)Ended earlyNCT06673069
What this trial is testing

Hero: A Study to Evaluate the Safety, Tolerability, and Pharmacokinetics (PK) and Pharmacodynamics (PD) of ION269 in Participants With Down Syndrome (DS) at Risk for Alzheimer's Disease (AD)

Who this might be right for
Alzheimer DiseaseDown Syndrome
Ionis Pharmaceuticals, Inc. 1
Early research (Phase 1)Not Yet RecruitingNCT07278492
What this trial is testing

NAD Augmentation to Prevent or Reverse Alzheimer's Disease in People With Down Syndrome

Who this might be right for
Down Syndrome (DS)
Brigham and Women's Hospital 24
Not applicableEnded earlyNCT00001178
What this trial is testing

Brain Study of Patients With Frontal Lobe Dementia and Parkinsonian Disorders

Who this might be right for
Alzheimer's DiseaseDementiaDown's Syndrome
National Institute of Neurological Disorders and Stroke (NINDS) 597
Large-scale testing (Phase 3)Looking for participantsNCT04390646
What this trial is testing

GnRH Therapy on Cognition in Down Syndrome

Who this might be right for
Down SyndromeCognitive DeclineAlzheimer Disease, Early Onset+1 more
Nelly Pitteloud 56
Not applicableStudy completedNCT02141971
What this trial is testing

Down Syndrome Biomarker Initiative (DSBI)

Who this might be right for
Down SyndromeAlzheimer's Disease
Michael Rafii 12
Early research (Phase 1)Study completedNCT06206824
What this trial is testing

Leucettinib-21 First-in-Human Phase 1 in Healthy Volunteers and Subjects With Down Syndrome and Alzheimer's Disease

Who this might be right for
Healthy VolunteersDown SyndromeAlzheimer's Disease
Perha Pharmaceuticals 152
Not applicableUnknownNCT03942341
What this trial is testing

Sleep in Adults With Down Syndrome and Alzheimer's Disease

Who this might be right for
Alzheimer's DiseaseObstructive Sleep ApneaSleep Disturbances
Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau 90
Testing effectiveness (Phase 2)Study completedNCT01699711
What this trial is testing

Normalization of dyrk1A and APP Function as an Approach to Improve Cognitive Performance and Decelerate AD Progression in DS Subjects: Epigallocatechin Gallate as Therapeutic Tool

Who this might be right for
Down Syndrome (DS)
Parc de Salut Mar 87
Not applicableStudy completedNCT04048759
What this trial is testing

The Promotion of Physical Activity for the Prevention of Alzheimer's Disease in Adults With Down Syndrome

Who this might be right for
Down SyndromeAlzheimer Disease
University of Kansas Medical Center 81
Not applicableUnknownNCT00965835
What this trial is testing

Amyloid Plaque and Tangle Imaging in Alzheimer's Disease and Down Syndrome

Who this might be right for
Down SyndromeAlzheimer's Disease
National Institute on Aging (NIA) 40
Not applicableLooking for participantsNCT06740162
What this trial is testing

Physical Activity and Community EmPOWERment Project

Who this might be right for
Intellectual DisabilityNeurodevelopmental DisordersAutism Spectrum Disorder+10 more
University of North Carolina, Chapel Hill 376
Large-scale testing (Phase 3)Ended earlyNCT06860373
What this trial is testing

LIFE-DSR-Biomarker Sub-study of Biomarkers in Down Syndrome Related Alzheimer's Disease (DS-AD)

Who this might be right for
Down Syndrome
LuMind IDSC Foundation 5
Next Page