Not applicableLooking for participantsNCT07347925What this trial is testingEffect of Pre-Hospital ARNI Therapy on Short-Term Outcomes in HFrEFWho this might be right forHeart Failure Future University in Egypt 140
Post-approval studies (Phase 4)Study completedNCT04023227What this trial is testingEfficacy and Safety of Sacubitril/Valsartan Compared With Enalapril on Morbidity, Mortality, and NT-proBNP Change in Patients With CCCWho this might be right forChagas DiseaseHeart Failure Novartis Pharmaceuticals 922
Large-scale testing (Phase 3)Study completedNCT03785405What this trial is testingOpen-label Extension Study to Evaluate Long-term Safety of Sacubitril/Valsartan in Pediatric Patients With HFWho this might be right forHeart Failure Novartis Pharmaceuticals 216
Large-scale testing (Phase 3)UnknownNCT04912167What this trial is testingThe Effects of Sacubitril-Valsartan vs Enalapril on Left Ventricular Remodeling in ST-elevation Myocardial InfarctionWho this might be right forSTEMI West China Hospital 376
Post-approval studies (Phase 4)Looking for participantsNCT06917664What this trial is testingTreatment of Moderate Ischemic Mitral Regurgitation in Patients With Coronary Artery DiseaseWho this might be right forCoronary Artery DiseaseIschemic Mitral RegurgitationAngiotensin Receptor/Neprilysin Inhibitor China National Center for Cardiovascular Diseases 220
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07261098What this trial is testingThe Efficacy and Safety of ARNI on the Outcome of Advanced Lung Cancer With Concurrent HypertensionWho this might be right forAdvanced Lung Cancer Shanghai Chest Hospital 200
Testing effectiveness (Phase 2)Study completedNCT01193101What this trial is testingEfficacy and Safety of LCZ696 Compared to Placebo in Patients With Essential HypertensionWho this might be right forHypertension Novartis Pharmaceuticals 389
Not applicableStudy completedNCT04397302What this trial is testingRole of Sacubitril/Valsartan in the Improvement of Heart Failure With Reduced Ejection FractionWho this might be right forHeart Failure, Left SidedLeft Ventricular DysfunctionVentricular Remodeling Italian Society of Cardiology 652
Large-scale testing (Phase 3)Study completedNCT04753112What this trial is testingTreatment of PH With Angiotensin II Receptor Blocker and Neprilysin Inhibitor in HFpEF Patients With CardioMEMS DeviceWho this might be right forPulmonary Hypertension Germans Trias i Pujol Hospital 14
Post-approval studies (Phase 4)Looking for participantsNCT07572032What this trial is testingDelayed Initiation of ARNI and SGLT2i in Heart Failure With Corrected Aetiology (DELAY-HF), Pilot StudyWho this might be right forHeart Failure Due to Coronary Artery DiseaseValvular CardiomyopathyHeart Failure Kyungsub Song 80
Testing effectiveness (Phase 2)Looking for participantsNCT06655480What this trial is testingTriple Combination Therapy (ARNI, SGLT2i, MRA) in Advanced HFpEFWho this might be right forHFpEFLVDDMyocardial Fibrosis National Medical Research Center for Cardiology, Ministry of Health of Russian Federation 50
Not applicableUnknownNCT04743063What this trial is testingProspective Monitoring of Angiotensin Receptor Neprilysin Inhibitor in Older Adults With Heart Failure and FrailtyWho this might be right forHeart Failure, SystolicFrailty Brigham and Women's Hospital 40,000
Testing effectiveness (Phase 2)Study completedNCT01281306What this trial is testingAn 8-week Study to Evaluate the Dose Response of AHU377 in Combination With Valsartan 320 mg in Patients With Mild-to-moderate Systolic HypertensionWho this might be right forSystolic Hypertension Novartis Pharmaceuticals 910
Post-approval studies (Phase 4)UnknownNCT04929600What this trial is testingSacubitril/Valsartan Versus Amlodipine in Hypertension and Left Ventricular Hypertrophy.Who this might be right forHypertensionLeft Ventricular Hypertrophy Shanghai Jiao Tong University School of Medicine 120
Not applicableUnknownNCT05922852What this trial is testingEffect of Novel Antidiabetic Drug Combined With Angiotensin Receptor/Neprilysin Inhibitor on Urinary ProteinWho this might be right forType 2 DiabetesAntidiabetic Drugs Peking University Third Hospital 1,000
Large-scale testing (Phase 3)Study completedNCT01615198What this trial is testingEfficacy and Safety of LCZ696 in Comparison to Olmesartan in Elderly Patients With Essential HypertensionWho this might be right forEssential Hypertension Novartis Pharmaceuticals 588
Not applicableStudy completedNCT03816306What this trial is testingSix Months Clinical and Echocardiographic Outcome of ARNI LCZ696 Therapy in HFrEF PatientsWho this might be right forHeart Failure With Reduced Ejection Fraction Mohammed Alnims 100
Not applicableNot Yet RecruitingNCT07465666What this trial is testingA Real-world Study of the Effectiveness of Angiotensin Receptor-Neprilysin Inhibitor Therapy in Hypertensive Patients in the United Arab EmiratesWho this might be right forHypertension Novartis Pharmaceuticals 500
Not applicableStudy completedNCT06915870What this trial is testingComparison of Empagliflozin and Dapagliflozin in Patients With Heart Failure Taking Standard TreatmentWho this might be right forDiabetes MellitusHeart Failure Fatima Maqsood 108
Testing effectiveness (Phase 2)Study completedNCT01256411What this trial is testingA Long-term (12 Months) Safety, Tolerability and Efficacy Study of LCZ696 in Patients With Essential HypertensionWho this might be right forEssential Hypertension Novartis Pharmaceuticals 341