Not applicableStudy completedNCT05629520What this trial is testingA Neurobiological Model of AnhedoniaWho this might be right forAnhedoniaDepression Milton S. Hershey Medical Center 60
Not applicableActive Not RecruitingNCT07199179What this trial is testingLink Between Reduction of Suicide Ideation by Esketamine in Add-On and Initial Levels of Psychological Pain and AnhedoniaWho this might be right forDepression - Major Depressive DisorderDepression DisorderSuicide University Hospital, Montpellier 456
Testing effectiveness (Phase 2)UnknownNCT03915613What this trial is testingBrain Insulin Resistance in Mood DisordersWho this might be right forMajor Depressive DisorderBipolar DisorderAnhedonia+1 more University Health Network, Toronto 150
Large-scale testing (Phase 3)Study completedNCT05550532What this trial is testingAticaprant 10 Milligrams (mg) as Adjunctive Therapy in Adult Participants With MDD With Moderate-to-severe Anhedonia and Inadequate Response to Current Antidepressant TherapyWho this might be right forDepressive Disorder, MajorAnhedonia Janssen Research & Development, LLC 444
Testing effectiveness (Phase 2)Study completedNCT04121091What this trial is testingPramipexole to Target "Anhedonic Depression"Who this might be right forDepression, BipolarDepression, UnipolarDysthymia+1 more Region Skane 13
Large-scale testing (Phase 3)Ended earlyNCT06635135What this trial is testingAticaprant Plus an Antidepressant to Prevent Return of Depression Symptoms in Participants With Major Depressive Disorder Who Experience a Loss of Interest and PleasureWho this might be right forDepressive Disorder, MajorAnhedonia Janssen Research & Development, LLC 47
Not applicableEnrolling By InvitationNCT07467473What this trial is testingCausal Role of Rostromedial Prefrontal Cortex for Positive Savoring in DepressionWho this might be right forLeft Rostromedial Prefrontal Cortex - Accelerated Intermittent Theta BurstLeft Dorsolateral Prefrontal Cortex - Accelerated Intermittent Theta BurstLeft Primary Somatosensory Cortex - Accelerated Intermittent Theta Burst Florida State University 48
Not applicableNot Yet RecruitingNCT07032428What this trial is testingEfficacy of kTMP, a Novel Non-invasive Brain Stimulation Method, for the Treatment of AnhedoniaWho this might be right forAnhedonia in Major Depressive Disorder Magnetic Tides 80
Not applicableStudy completedNCT05870501What this trial is testingSynaptic Imaging and Network Activity in Treatment Resistant DepressionWho this might be right forDepressive DisorderDepressive Disorder, MajorDepressive Disorder, Treatment-Resistant+5 more King's College London 56
Early research (Phase 1)UnknownNCT05320107What this trial is testingThe Effect of Ketamine on Aesthetics and Role for Antidepressant EffectsWho this might be right forMajor Depressive Disorder Medical University of Vienna 60
Testing effectiveness (Phase 2)Looking for participantsNCT07493317What this trial is testingNeutralizing Interleukin (IL)-6Who this might be right forMajor Depressive Disorder Icahn School of Medicine at Mount Sinai 60
Post-approval studies (Phase 4)Looking for participantsNCT06610305What this trial is testingOvarian Hormone Withdrawal, Anhedonia, and Reward Sensitivity in Women With Premenstrual Exacerbations of DepressionWho this might be right forMajor Depressive Disorder University of North Carolina, Chapel Hill 75
Not applicableStudy completedNCT04977232What this trial is testingAdjunctive Game Intervention for Anhedonia in MDD PatientsWho this might be right forDepression Central South University 50
Testing effectiveness (Phase 2)WithdrawnNCT05601648What this trial is testingPET Synaptogenesis After Psilocybin In DEpression RecoveryWho this might be right forMajor Depressive DisorderAnhedonia Washington University School of Medicine
Not applicableStudy completedNCT00082030What this trial is testingFunction of Catecholamines in the Brain During DepressionWho this might be right forDepressionInvolutional National Institute of Mental Health (NIMH) 71
Not applicableStudy completedNCT01659814What this trial is testingDopamine Neurotransmission in Major DepressionWho this might be right forMajor Depressive DisorderAnhedonia Mclean Hospital 71
Not applicableLooking for participantsNCT06363981What this trial is testingMultisite rTMS for Mood, Cognitive Impairment and Other Symptoms of DepressionWho this might be right forUnipolar DepressionBipolar Disorder Jakub Antczak 90
Not applicableLooking for participantsNCT06086366What this trial is testingPresynaptic Imaging in Major Depressive Episodes After COVID-19Who this might be right forLong COVIDMajor Depressive DisorderMajor Depressive Episode Centre for Addiction and Mental Health 90
Not applicableStudy completedNCT00183755What this trial is testingUnderstanding Brain Reward Responses in Individuals With Major Depressive DisorderWho this might be right forDepression Mclean Hospital 87
Testing effectiveness (Phase 2)Study completedNCT05165394What this trial is testingStudy to Evaluate the Efficacy and Safety of Once-Weekly Oral NBI-1065846 in the Treatment of Anhedonia in MDDWho this might be right forAnhedoniaMajor Depressive Disorder Neurocrine Biosciences 93