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Results for “Antibody-Drug Conjugate”

412 trials

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Showing 20 of 412 results

Early research (Phase 1)Looking for participantsNCT05464030
What this trial is testing

Anti-CEACAM5 ADC M9140 in Advanced Solid Tumors (PROCEADE-CRC-01)

Who this might be right for
Colorectal Cancer
EMD Serono Research & Development Institute, Inc. 200
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07460375
What this trial is testing

Evaluate Claudin 18.2-Directed ADC LCB02A in Advanced Solid Tumors

Who this might be right for
Advanced Solid Tumors
LigaChem Biosciences, Inc. 191
Large-scale testing (Phase 3)Looking for participantsNCT06989112
What this trial is testing

DESTINY-Endometrial01: A Phase III Study of Trastuzumab Deruxtecan Plus Rilvegostomig or Pembrolizumab as First-Line Treatment of HER2-Expressing (IHC 3+/2+), Mismatch Repair Proficient (pMMR) Endometrial Cancer

Who this might be right for
Endometrial Cancer
AstraZeneca 600
Testing effectiveness (Phase 2)Ended earlyNCT06563804
What this trial is testing

Evaluate S227928 as a Single Agent and in Combination With Venetoclax in Patients With R/R AML, MDS/AML, or CMML

Who this might be right for
Relapsed/Refractory (R/R) Acute Myeloid Leukemia (AML)Myelodysplastic Syndrome (MDS)/AMLChronic Myelomonocytic Leukemia (CMML)
Servier Bio-Innovation LLC 13
Early research (Phase 1)Looking for participantsNCT06041516
What this trial is testing

A First-in-Human Phase I Trial With Antibody Drug Conjugate ADCT-701 in Neuroendocrine Tumors, Carcinomas and Malignant Peripheral Nerve Sheath Tumors

Who this might be right for
Neuroendocrine CarcinomasNeuroendocrine TumorsCarcinoma, Neuroendocrine+2 more
National Cancer Institute (NCI) 70
Testing effectiveness (Phase 2)Ended earlyNCT01440179
What this trial is testing

SAR3419 in Acute Lymphoblastic Leukemia

Who this might be right for
Acute Lymphocytic Leukaemia
Sanofi 100
Early research (Phase 1)Looking for participantsNCT07067567
What this trial is testing

AK146D1 for Injection in Advanced Solid Tumors

Who this might be right for
Advanced Solid Tumors
Akeso 200
Testing effectiveness (Phase 2)Looking for participantsNCT06953089
What this trial is testing

DB-1311 in Combination With BNT327 or DB-1305 in Advanced/Metastatic Solid Tumors

Who this might be right for
Solid Tumors
DualityBio Inc. 492
Early research (Phase 1)Looking for participantsNCT06625593
What this trial is testing

A First-in-Human (FIH) Study of BG-C137, an Anti-Fibroblast Growth Factor Receptor 2b (FGFR2b) Antibody Drug Conjugate, in Participants With Advanced Solid Tumors

Who this might be right for
Advanced Solid Tumor
BeOne Medicines 168
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07528898
What this trial is testing

Neoadjuvant SHR-A1811 Combined With Pertuzumab in HER2-Positive Breast Cancer: An Exploratory Clinical Study.

Who this might be right for
Breast Cancer
Hebei Medical University Fourth Hospital 100
Early research (Phase 1)Study completedNCT03383692
What this trial is testing

Study of DS-8201a for Participants With Advanced Solid Malignant Tumors

Who this might be right for
Neoplasm Metastasis
Daiichi Sankyo Co., Ltd. 40
Early research (Phase 1)Looking for participantsNCT06908928
What this trial is testing

A Dose Randomization Study of Bulumtatug Fuvedotin in TNBC Patients Previously Treated With ADCs

Who this might be right for
Triple Negative Breast Cancer
Mabwell (Shanghai) Bioscience Co., Ltd. 52
Early research (Phase 1)Looking for participantsNCT06440005
What this trial is testing

Evaluate Safety, Tolerability and Preliminary Activity of AGX101 in Participants With Advanced Solid Tumors

Who this might be right for
CancerAdvanced CancerLocally Advanced Carcinoma+8 more
Angiex, Inc. 80
Not applicableLooking for participantsNCT06927895
What this trial is testing

Breast Cancer Implementation Science Study With Educational Intervention

Who this might be right for
Breast Cancer
NYU Langone Health 30
Not applicableLooking for participantsNCT07379268
What this trial is testing

Evaluation of the Efficacy of Anti-HER2 Antibody-Drug Conjugates (ADC) in Locally Advanced or Metastatic Bladder Cancer Based on Organoid Technology.

Who this might be right for
Bladder Cancer
Qilu Hospital of Shandong University 224
Early research (Phase 1)Looking for participantsNCT07082920
What this trial is testing

JNJ-78278343 in Combination With JNJ-95298177 for Treatment of Prostate Cancer

Who this might be right for
Prostatic Neoplasms
Janssen Research & Development, LLC 140
Large-scale testing (Phase 3)Looking for participantsNCT06103864
What this trial is testing

A Phase III Study of Dato-DXd With or Without Durvalumab Compared With Investigator's Choice of Chemotherapy in Combination With Pembrolizumab in Patients With PD-L1 Positive Locally Recurrent Inoperable or Metastatic Triple-negative Breast Cancer

Who this might be right for
Breast Cancer
AstraZeneca 625
Large-scale testing (Phase 3)Ended earlyNCT02785900
What this trial is testing

Vadastuximab Talirine (SGN-CD33A; 33A) Combined With Azacitidine or Decitabine in Older Patients With Newly Diagnosed Acute Myeloid Leukemia

Who this might be right for
Acute Myeloid Leukemia
Seagen Inc. 240
Testing effectiveness (Phase 2)Looking for participantsNCT07299747
What this trial is testing

Clinical Trial of VBC103 in Patients With Advanced Malignant Solid Tumors

Who this might be right for
Participants With Advanced Solid Tumor Malignancies
VelaVigo Bio Inc 255
Not applicableLooking for participantsNCT06877416
What this trial is testing

Analysis of Exploring Optimized Sequential Treatment Strategies of Antibody-Drug Conjugates (ADCs) in HER2-Low-Expressing Breast Cancer

Who this might be right for
Antibody-drug ConjugatesHER2-low Breast CancerBreast Neoplasms
Sun Yat-sen University 700
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