Early research (Phase 1)Study completedNCT04208152What this trial is testingA First-in-Human Study of Single and Multiple Doses of anle138b in Healthy SubjectsWho this might be right forHealthy Volunteers MODAG GmbH 68
Testing effectiveness (Phase 2)Study completedNCT03977584What this trial is testingTau Positron Emission Tomography (PET) Longitudinal Substudy Associated With: Study of Crenezumab Versus Placebo in Preclinical Presenilin1 (PSEN1) E280A Mutation Carriers in the Treatment of Autosomal-Dominant Alzheimer's DiseaseWho this might be right forAlzheimer Disease Hoffmann-La Roche 114
Large-scale testing (Phase 3)Not Yet RecruitingNCT06996730What this trial is testingDonanemab, RG6289, or the Combination of Donanemab and RG6289 in Presenilin 1 (PSEN1) E280A Mutation Carriers for the Treatment of Autosomal-Dominant Alzheimer's DiseaseWho this might be right forAutosomal Dominant Alzheimers DiseaseEarly Onset Alzheimer DiseaseAlzheimers Disease Banner Health 240
Not applicableLooking for participantsNCT06733714What this trial is testingAssociation of Transcranial Alternating Current Stimulation with Digital Cognitive Training for Cognitive Remediation in Older AdultsWho this might be right forCognitive DysfunctionAlzheimer DiseaseMild Cognitive Impairment+8 more Universidade Federal do Rio de Janeiro 40
Not applicableStudy completedNCT01622894What this trial is testingGenetics of Mendelian Forms of Young Onset Alzheimer DiseaseWho this might be right forAutosomal Dominant Cases of Alzheimer 's Disease University Hospital, Rouen 150
Large-scale testing (Phase 3)Looking for participantsNCT06647498What this trial is testingA Potential Disease Modifying Treatment in Individuals at Risk for or With a Type of Early Onset AD Caused by a Genetic MutationWho this might be right forAlzheimers DiseaseDementiaAlzheimers Disease, Familial Washington University School of Medicine 280
Early research (Phase 1)Study completedNCT05532358What this trial is testingA Drug-Drug Interaction Study to Assess the CYP1A2 and CYP3A4 Interaction Potential of TEV-56286 (anle138b)Who this might be right forHealthy Volunteers MODAG GmbH 54
Large-scale testing (Phase 3)Active Not RecruitingNCT05269394What this trial is testingDominantly Inherited Alzheimer Network Trial: An Opportunity to Prevent Dementia. A Study of Potential Disease Modifying Treatments in Individuals With a Type of Early Onset Alzheimer's Disease Caused by a Genetic Mutation (DIAN-TU)Who this might be right forAlzheimers DiseaseDementiaAlzheimers Disease, Familial Washington University School of Medicine 197
Large-scale testing (Phase 3)Ended earlyNCT06424236What this trial is testingDominantly Inherited Alzheimer Network Trial: An Opportunity to Prevent Dementia: A Study of Potential Disease Modifying Treatments in Individuals at Risk for or With a Type of Early Onset Alzheimer's Disease Caused by a Genetic MutationWho this might be right forAlzheimers DiseaseDementiaAlzheimers Disease, Familial Washington University School of Medicine 73
Not applicableEnrolling By InvitationNCT04104659What this trial is testingStudy of Tau Imaging With the Use of [18F]MK-6240 TracerWho this might be right forAlzheimer Disease Tammie L. S. Benzinger, MD, PhD 200
Early research (Phase 1)Study completedNCT04685265What this trial is testingAssess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of anle138b in Parkinson's DiseaseWho this might be right forParkinson Disease MODAG GmbH 70
Not applicableLooking for participantsNCT00869817What this trial is testingDominantly Inherited Alzheimer Network (DIAN)Who this might be right forAlzheimer's Disease Washington University School of Medicine 700
Large-scale testing (Phase 3)Looking for participantsNCT05552157What this trial is testingPotential Disease Modifying Treatments in Individuals at Risk for or With a Type of Early Onset AD Caused by a Genetic MutationWho this might be right forAlzheimers DiseaseDementiaAlzheimers Disease, Familial Washington University School of Medicine 280
Testing effectiveness (Phase 2)Study completedNCT01998841What this trial is testingCrenezumab Versus Placebo in Preclinical Presenilin1 (PSEN1) E280A Mutation Carriers to Evaluate Efficacy and Safety in the Treatment of Autosomal-Dominant Alzheimer's Disease (AD), Including a Placebo-Treated Non-Carrier CohortWho this might be right forAlzheimer's Disease Genentech, Inc. 252
Large-scale testing (Phase 3)Active Not RecruitingNCT01760005What this trial is testingDominantly Inherited Alzheimer Network Trial: An Opportunity to Prevent Dementia. A Study of Potential Disease Modifying Treatments in Individuals at Risk for or With a Type of Early Onset Alzheimer's Disease Caused by a Genetic Mutation. Master Protocol DIAN-TU-001Who this might be right forAlzheimers DiseaseDementiaAlzheimers Disease, Familial Washington University School of Medicine 490
Early research (Phase 1)Looking for participantsNCT06372821What this trial is testingA Trial Evaluating the Effect of NIO752 on Tau Synthesis Measured by a Process Known as SILKWho this might be right forAlzheimer DiseaseAutosomal Dominant Alzheimer Disease Due to Mutation of Presenilin 1 (Disorder)Autosomal Dominant Alzheimer Disease Due to Mutation of Presenilin 2 (Disorder)+1 more University College, London 10
Large-scale testing (Phase 3)Study completedNCT04623242What this trial is testingDominantly Inherited Alzheimer Network Trial: An Opportunity to Prevent Dementia. A Study of Potential Disease Modifying Treatments in Individuals at Risk for or With a Type of Early Onset Alzheimer's Disease Caused by a Genetic Mutation.Who this might be right forAlzheimers DiseaseDementiaAlzheimers Disease, Familial Washington University School of Medicine 194
Large-scale testing (Phase 3)Active Not RecruitingNCT06384573What this trial is testingDIAN-TU Amyloid Removal Trial (ART) in Dominantly Inherited Alzheimer's DiseaseWho this might be right forAlzheimer's DiseaseDementiaAlzheimer's Disease, Familial Washington University School of Medicine 43
Early research (Phase 1)Looking for participantsNCT05469360What this trial is testingStudy of Safety, Tolerability, Pharmacodynamics and Pharmacokinetics of NIO752 in Early Alzheimer's Disease ParticipantsWho this might be right forAlzheimer DiseaseMild Cognitive Impairment Novartis Pharmaceuticals 36