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Results for “Autosomal Dominant Alzheimers Disease”

19 trials

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Showing 19 of 19 results

Large-scale testing (Phase 3)Ended earlyNCT06424236
What this trial is testing

Dominantly Inherited Alzheimer Network Trial: An Opportunity to Prevent Dementia: A Study of Potential Disease Modifying Treatments in Individuals at Risk for or With a Type of Early Onset Alzheimer's Disease Caused by a Genetic Mutation

Who this might be right for
Alzheimers DiseaseDementiaAlzheimers Disease, Familial
Washington University School of Medicine 73
Early research (Phase 1)Study completedNCT04208152
What this trial is testing

A First-in-Human Study of Single and Multiple Doses of anle138b in Healthy Subjects

Who this might be right for
Healthy Volunteers
MODAG GmbH 68
Large-scale testing (Phase 3)Study completedNCT04623242
What this trial is testing

Dominantly Inherited Alzheimer Network Trial: An Opportunity to Prevent Dementia. A Study of Potential Disease Modifying Treatments in Individuals at Risk for or With a Type of Early Onset Alzheimer's Disease Caused by a Genetic Mutation.

Who this might be right for
Alzheimers DiseaseDementiaAlzheimers Disease, Familial
Washington University School of Medicine 194
Early research (Phase 1)Study completedNCT04685265
What this trial is testing

Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of anle138b in Parkinson's Disease

Who this might be right for
Parkinson Disease
MODAG GmbH 70
Early research (Phase 1)Looking for participantsNCT06372821
What this trial is testing

A Trial Evaluating the Effect of NIO752 on Tau Synthesis Measured by a Process Known as SILK

Who this might be right for
Alzheimer DiseaseAutosomal Dominant Alzheimer Disease Due to Mutation of Presenilin 1 (Disorder)Autosomal Dominant Alzheimer Disease Due to Mutation of Presenilin 2 (Disorder)+1 more
University College, London 10
Early research (Phase 1)Study completedNCT05532358
What this trial is testing

A Drug-Drug Interaction Study to Assess the CYP1A2 and CYP3A4 Interaction Potential of TEV-56286 (anle138b)

Who this might be right for
Healthy Volunteers
MODAG GmbH 54
Not applicableLooking for participantsNCT06733714
What this trial is testing

Association of Transcranial Alternating Current Stimulation with Digital Cognitive Training for Cognitive Remediation in Older Adults

Who this might be right for
Cognitive DysfunctionAlzheimer DiseaseMild Cognitive Impairment+8 more
Universidade Federal do Rio de Janeiro 40
Not applicableEnrolling By InvitationNCT04104659
What this trial is testing

Study of Tau Imaging With the Use of [18F]MK-6240 Tracer

Who this might be right for
Alzheimer Disease
Tammie L. S. Benzinger, MD, PhD 200
Large-scale testing (Phase 3)Active Not RecruitingNCT06384573
What this trial is testing

DIAN-TU Amyloid Removal Trial (ART) in Dominantly Inherited Alzheimer's Disease

Who this might be right for
Alzheimer's DiseaseDementiaAlzheimer's Disease, Familial
Washington University School of Medicine 40
Large-scale testing (Phase 3)Not Yet RecruitingNCT06996730
What this trial is testing

Donanemab, RG6289, or the Combination of Donanemab and RG6289 in Presenilin 1 (PSEN1) E280A Mutation Carriers for the Treatment of Autosomal-Dominant Alzheimer's Disease

Who this might be right for
Autosomal Dominant Alzheimers DiseaseEarly Onset Alzheimer DiseaseAlzheimers Disease
Banner Health 240
Testing effectiveness (Phase 2)Study completedNCT01998841
What this trial is testing

Crenezumab Versus Placebo in Preclinical Presenilin1 (PSEN1) E280A Mutation Carriers to Evaluate Efficacy and Safety in the Treatment of Autosomal-Dominant Alzheimer's Disease (AD), Including a Placebo-Treated Non-Carrier Cohort

Who this might be right for
Alzheimer's Disease
Genentech, Inc. 252
Not applicableStudy completedNCT01622894
What this trial is testing

Genetics of Mendelian Forms of Young Onset Alzheimer Disease

Who this might be right for
Autosomal Dominant Cases of Alzheimer 's Disease
University Hospital, Rouen 150
Large-scale testing (Phase 3)Looking for participantsNCT06647498
What this trial is testing

A Potential Disease Modifying Treatment in Individuals at Risk for or With a Type of Early Onset AD Caused by a Genetic Mutation

Who this might be right for
Alzheimers DiseaseDementiaAlzheimers Disease, Familial
Washington University School of Medicine 280
Early research (Phase 1)Looking for participantsNCT05469360
What this trial is testing

Study of Safety, Tolerability, Pharmacodynamics and Pharmacokinetics of NIO752 in Early Alzheimer's Disease Participants

Who this might be right for
Alzheimer DiseaseMild Cognitive Impairment
Novartis Pharmaceuticals 36
Testing effectiveness (Phase 2)Study completedNCT03977584
What this trial is testing

Tau Positron Emission Tomography (PET) Longitudinal Substudy Associated With: Study of Crenezumab Versus Placebo in Preclinical Presenilin1 (PSEN1) E280A Mutation Carriers in the Treatment of Autosomal-Dominant Alzheimer's Disease

Who this might be right for
Alzheimer Disease
Hoffmann-La Roche 114
Large-scale testing (Phase 3)Active Not RecruitingNCT05269394
What this trial is testing

Dominantly Inherited Alzheimer Network Trial: An Opportunity to Prevent Dementia. A Study of Potential Disease Modifying Treatments in Individuals With a Type of Early Onset Alzheimer's Disease Caused by a Genetic Mutation (DIAN-TU)

Who this might be right for
Alzheimers DiseaseDementiaAlzheimers Disease, Familial
Washington University School of Medicine 197
Large-scale testing (Phase 3)Looking for participantsNCT05552157
What this trial is testing

Potential Disease Modifying Treatments in Individuals at Risk for or With a Type of Early Onset AD Caused by a Genetic Mutation

Who this might be right for
Alzheimers DiseaseDementiaAlzheimers Disease, Familial
Washington University School of Medicine 280
Large-scale testing (Phase 3)Active Not RecruitingNCT01760005
What this trial is testing

Dominantly Inherited Alzheimer Network Trial: An Opportunity to Prevent Dementia. A Study of Potential Disease Modifying Treatments in Individuals at Risk for or With a Type of Early Onset Alzheimer's Disease Caused by a Genetic Mutation. Master Protocol DIAN-TU-001

Who this might be right for
Alzheimers DiseaseDementiaAlzheimers Disease, Familial
Washington University School of Medicine 490
Not applicableLooking for participantsNCT00869817
What this trial is testing

Dominantly Inherited Alzheimer Network (DIAN)

Who this might be right for
Alzheimer's Disease
Washington University School of Medicine 700