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Results for “Avutometinib”

20 trials

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Showing 20 of 20 results

Early research (Phase 1)Not Yet RecruitingNCT07318324
What this trial is testing

Phase Ib Study of Avutometinib, Defactinib, and Everolimus in RAS Pathway Mutant Endometrial Cancer

Who this might be right for
Phase IBAvutometinibRAS Pathway+1 more
M.D. Anderson Cancer Center 31
Testing effectiveness (Phase 2)Looking for participantsNCT06487221
What this trial is testing

Avutometinib and Defactinib in Diffuse Gastric Cancer

Who this might be right for
Gastric CancerStomach Cancer
Ryan H. Moy, MD, PhD 27
Testing effectiveness (Phase 2)Active Not RecruitingNCT05375994
What this trial is testing

Study of Avutometinib (VS-6766) + Adagrasib in KRAS G12C NSCLC Patients

Who this might be right for
Non Small Cell Lung CancerKRAS Activating MutationAdvanced Cancer+3 more
Verastem, Inc. 85
Testing effectiveness (Phase 2)Study completedNCT04620330
What this trial is testing

Avutometinib (VS-6766) + Defactinib in Recurrent KRAS G12V, Other KRAS and BRAF Non-Small Cell Lung Cancer

Who this might be right for
Non Small Cell Lung CancerKRAS Activating Mutation
Verastem, Inc. 90
Testing effectiveness (Phase 2)Looking for participantsNCT05787561
What this trial is testing

Avutometinib (VS-6766) and Defactinib in People With Mesonephric Gynecologic Cancer

Who this might be right for
Mesonephric Gynecologic Cancer
Memorial Sloan Kettering Cancer Center 40
Testing effectiveness (Phase 2)Active Not RecruitingNCT05669482
What this trial is testing

Study of Avutometinib (VS-6766) +Defactinib With Gemcitabine and Nab-paclitaxel in Patients With Pancreatic Cancer

Who this might be right for
KRAS Activating MutationMetastatic CancerPancreas Cancer+2 more
Verastem, Inc. 40
Testing effectiveness (Phase 2)Active Not RecruitingNCT06682572
What this trial is testing

Avutometinib + Defactinib in Recurrent Low-Grade Serous Ovarian Cancer in Japanese Patients

Who this might be right for
Low Grade Serous Ovarian CancerOvarian Cancer
Verastem, Inc. 16
Testing effectiveness (Phase 2)Looking for participantsNCT05512208
What this trial is testing

Avutometinib (VS-6766) Plus Defactinib

Who this might be right for
Endometrioid CancerMucinous Ovarian CancerHigh Grade Serous Ovarian Cancer+2 more
University of Oklahoma 55
Large-scale testing (Phase 3)Looking for participantsNCT06072781
What this trial is testing

Avutometinib (VS-6766) + Defactinib (VS-6063) in Recurrent Low-Grade Serous Ovarian Cancer

Who this might be right for
Low Grade Serous Ovarian Cancer
Verastem, Inc. 270
Testing effectiveness (Phase 2)Looking for participantsNCT06194929
What this trial is testing

Defactinib and Avutometinib, With or Without Encorafenib, for the Treatment of Patients With Brain Metastases From Cutaneous Melanoma

Who this might be right for
Cutaneous MelanomaBrain Metastases
University of Utah 33
Testing effectiveness (Phase 2)Looking for participantsNCT06007924
What this trial is testing

Avutometinib and Defactinib in People With Thyroid Cancer

Who this might be right for
Thyroid Cancer
Memorial Sloan Kettering Cancer Center 30
Testing effectiveness (Phase 2)Looking for participantsNCT06369259
What this trial is testing

Open-label Phase 2 Study of Avutometinib (RAF/MEK Clamp) in Combination With Defactinib (FAK Inhibitor) and Cetuximab in Patients With Unresectable, Anti-EGFR-Refractory Advanced Colorectal Cancer

Who this might be right for
Advanced Colorectal Cancer
M.D. Anderson Cancer Center 33
Testing effectiveness (Phase 2)Active Not RecruitingNCT05074810
What this trial is testing

Phase 1/2 Study of Avutometinib (VS-6766) + Sotorasib With or Without Defactinib in KRAS G12C NSCLC Patients

Who this might be right for
Non Small Cell Lung CancerKRAS Activating Mutation
Verastem, Inc. 153
Testing effectiveness (Phase 2)Temporarily pausedNCT05200442
What this trial is testing

VS-6766 and Cetuximab in Patients With Advanced Colorectal Cancer

Who this might be right for
Colorectal CancerColorectal AdenocarcinomaColorectal Cancer Metastatic+2 more
University of Chicago 53
Early research (Phase 1)Looking for participantsNCT06104488
What this trial is testing

Avutometinib for People With Solid Tumor Cancers

Who this might be right for
Refractory CancerCNS TumorsCNS Tumor, Adult+12 more
Memorial Sloan Kettering Cancer Center 23
Testing effectiveness (Phase 2)Looking for participantsNCT06630260
What this trial is testing

5G-RUBY: Avutometinib and Defactinib in Malignant Brain Tumours

Who this might be right for
Glioblastoma Multiforme (GBM)Glioblastoma Multiform (Grade IV Astrocytoma)Diffuse Hemispheric Glioma, H3 G34-Mutant+1 more
Institute of Cancer Research, United Kingdom 182
Testing effectiveness (Phase 2)Active Not RecruitingNCT04625270
What this trial is testing

Avutometinib (VS-6766) v. Avutometinib (VS-6766) + Defactinib in Recurrent Low-Grade Serous Ovarian Cancer With and Without a KRAS Mutation

Who this might be right for
Low Grade Ovarian Serous AdenocarcinomaOvarian Cancer
Verastem, Inc. 225
Testing effectiveness (Phase 2)Looking for participantsNCT05608252
What this trial is testing

VS-6766+Abema+Fulv in Met HR+/HER- BC

Who this might be right for
Breast CancerHormone Receptor-positive Breast CancerHormone Receptor Positive HER-2 Negative Breast Cancer
Adrienne G. Waks 63
Testing effectiveness (Phase 2)Looking for participantsNCT06495125
What this trial is testing

Defactinib, Avutometinib and Nivolumab for the Treatment of Anti-PD1 Refractory LKB1-Mutant Advanced Non-Small Cell Lung Cancer

Who this might be right for
Advanced Lung AdenocarcinomaRefractory Lung AdenocarcinomaStage III Lung Cancer AJCC v8+1 more
Emory University 50
Testing effectiveness (Phase 2)Looking for participantsNCT06394804
What this trial is testing

Avutometinib, Defactinib, and Letrozole in People With Low-Grade Serous Ovarian Cancer

Who this might be right for
Low-Grade Serous Ovarian Cancer
Memorial Sloan Kettering Cancer Center 20